Linkage Analysis

Descrição

Year 2 Quiz sobre Linkage Analysis, criado por gina_evans0312 em 26-12-2013.
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Quiz por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312 quase 11 anos atrás
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1

Resumo de Recurso

Questão 1

Questão
Metaphase is the most important stage for genetic mapping
Responda
  • True
  • False

Questão 2

Questão
Recombination cannot be detected in...
Responda
  • Homozygotes
  • Heterozygotes
  • Because both alleles are different
  • Because both alleles are identical

Questão 3

Questão
What indicates linkage?
Responda
  • The no of recombinants
  • The no of homozygotes
  • The no of heterozygotes

Questão 4

Questão
A generation bred from parents AB & ab, has 1 recombinant out of 20- is linkage involved
Responda
  • Yes
  • No

Questão 5

Questão
Recombinant detecting probes can be fooled if double recombination occurs
Responda
  • True
  • False

Questão 6

Questão
Which of the following gametes tend to recombine more around the centromere?
Responda
  • Spermatocytes
  • Oocytes

Questão 7

Questão
Oocytes tend to recombine
Responda
  • Around the telomeres
  • Around the centromere
  • More than spermatocytes
  • Less than spermatocytes

Questão 8

Questão
Most recombination occurs at random
Responda
  • True
  • False

Questão 9

Questão
What is 1q42.3 referring to?
Responda
  • Short arm of chromosome 1
  • Long arm of chromosome 1
  • Locus position (from telomere to centromere)
  • Locus position (from centromere to telomere)

Questão 10

Questão
Meiosis is made informative or uninformative depending on whether you can track the diseased allele
Responda
  • True
  • False

Questão 11

Questão
What must be known for effective meosic analysis?
Responda
  • Grandparent -> Grandchild phenotype
  • Grandchild & all siblings phenotype
  • Parent & all siblings -> Grandchild phenotype

Questão 12

Questão
Is the following informative for linkage analysis?
Responda
  • Yes- the child is a recombinant
  • No- the child is heterozygous
  • No- the father is homozygous

Questão 13

Questão
How would you classify this?
Responda
  • Uninformative non-recombinant
  • Informative recombinant
  • Informative Non-recombinant

Questão 14

Questão
This is an informative recombinant
Responda
  • True
  • False

Questão 15

Questão
What is true of Recombinant/Human Pedigree Analysis?
Responda
  • The lower the recombination frequency, the more likely the hypothysis is to be correct
  • The higher the recombination frequency, the more likely the hypothysis is to be correct

Questão 16

Questão
A mother has a disease, and has the alleles M1 & M2- what are the two hypothesis for pedigree analysis?
Responda
  • M1 is diseased M2 is healthy
  • M1 is healthy M2 is diseased
  • M1 & M2 are healthy
  • M1 & M2 are diseased

Questão 17

Questão
Give the two Recombination frequencies for that above image
Responda
  • 0.16 & 0.83
  • 1.66 & 8.33
  • 16.66 & 83.33

Questão 18

Questão
A higher recombination frequency means alleles are closer together
Responda
  • True
  • False

Questão 19

Questão
Define a Marker
Responda
  • Any mendelian character that can be used to follow a disease through a pedigree
  • A fluorescent dye used to find particular alleles
  • A mutagen used to create findable mutations

Semelhante

Genetic Disorders
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Disease Pedigree Definitions
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Genetic Mapping
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Markers
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Micro RNA
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