455509
Descrição
Quiz por gina_evans0312, atualizado more than 1 year ago
|
Criado por gina_evans0312
aproximadamente 11 anos atrás
|
|
Questão 1
Questão
Linkage mapping- determining the distance between & order of genes
Responda
- True
- False
Questão 2
Questão
Genetic maps are measured in bp, physical maps in cM
Responda
- True
- False
Questão 3
Questão
Linkage _ reflects gene proximity
Responda
-
Directly
-
Indirectly
-
Loosely
Questão 4
Questão
Genes on different chromosomes link dependently
Responda
- True
- False
Questão 5
Questão
What are the two definitions of haplotype?
Responda
-
A set of genes on the same chromosome
-
The genes contained in two homologous chromosomes
-
A set of genetic determinants
Questão 6
Responda
-
The recombination frequency
-
The location of the SNP marker
-
The first infected generation
Questão 7
Questão
Name two resons why large families are required for linkage studies in humans (for an accurate result)
Responda
-
Human families are small
-
Humans cannot be bred just to investigate phenotypes
-
Human genes are highly conserved
-
Human gene markers are rare
Questão 8
Questão
If 15% of meioses in a study show crossover, what is the recombination frequency?
Responda
-
15%
-
30%
-
85%
Questão 9
Questão
Loci with a recombination factor of 50% have the same chance of being separated as loci on different chromosomes
Responda
- True
- False
Questão 10
Questão
Name the two steps required for functional mapping
Responda
-
Find what haplotype those with the mutations share
-
Find what markers those with the mutations share
-
Look for markers close to it
-
Look for genes close to it
Questão 11
Questão
What is the 'Critical Region'
Responda
-
There area containing the mutated gene
-
The area containing the related marker
Questão 12
Questão
A, B, C & D are all markers. B and C are found in homozygous form in people with autosomal recessive deafness. Where is the critical regions for genes causing this deafness?
Image:
Critical_Region (image/png)
Responda
-
Between B & C
-
Between A & D
-
Between B & D
-
Between A & C
Questão 13
Questão
Assuming a person is heterozygous, what do we need to know once markers for the alleles have been identified?
Responda
-
Which marker is segregated with which allele i.e A1D A2d, or A1d A2D
-
Which allele is diseased i.e. D or d
-
Which marker has bonded correctly
Questão 14
Questão
What is the difference between phase known and phase unknown?
Responda
-
In phase known, we know which allele contains the diease
-
In phase known, we have the genotype of the grandparents
-
In phase known, we don't know how many recombinants there are
Questão 15
Questão
Fewer recombinants mean the hypothesis is more likely
Responda
- True
- False
Questão 16
Questão
Assume 12% of people are recombinants - how many cM are the genes?
Responda
-
24cM
-
12cM
-
88cM
Questão 17
Questão
Name 3 things that can affect the recombination process
Responda
-
Crossover hotspots
-
Crossovers are common near centromeres
-
Crossovers are rarer near centromeres
-
Oocytes crossover more frequently than sperm
-
Sperm crossover more frequently than oocytes
Questão 18
Questão
LOD - Log of the Odds Ratio
Responda
- True
- False
Questão 19
Questão
When using LOD, what are the two hypothesis?
Responda
-
There is a given (previously calculated) linkage frequency
-
There is null (50% or more) linkage frequency
Questão 20
Questão
Assuming 6 recombinants out of 10 children what is the equation for the statistical likelihood of 6 recombinents?
Responda
-
[(1-θ)^6] x θ
-
[(1+θ)/6] x θ
-
[6 x θ] x θ
Questão 21
Questão
The equation for NO linkage = [(1-θ)^no of children in study]
Responda
- True
- False
Questão 22
Questão
A = Liklihood of linkage
B = Liklihood of no linkage
What is the LOD full equation?
Responda
-
Log10 (A/B)
-
Log10 (B/A)
-
Log10 (A-B)
-
Log10 (A x B)
Questão 23
Questão
-2 is considered significant, 3 is considered no linkage
Responda
- True
- False
Questão 24
Questão
It is thought that 4 of 13 children are recombinants- calculate the LOD and see if this is significant
Responda
-
Yes
-
No
Questão 25
Questão
LOD scores are not additive
Responda
- True
- False
Questão 26
Questão
Linkage analysis in complex disorders is much more difficult
Responda
- True
- False
Questão 27
Questão
The first step of mapping complex disease genes is demonstrating how important the genes are on heritability
Responda
- True
- False
Questão 28
Questão
How do you gain estimates of heritability in complex disorders?
Responda
-
Look at mono/dizygotic twins
-
Look at siblings
-
Look at familial generations
Questão 29
Questão
Why is linkage analysis so much more difficult with complex disorders?
Responda
-
We don't know penetrance
-
We don't know how many genes are involved
-
We don't know the relative effect of each gene
Questão 30
Questão
Non-parametric linkage analysis typically uses what?
Responda
-
Affected twins
-
Affected sibling pairs
-
Affected spouses
Questão 31
Questão
What is true of NPL?
Responda
-
No assumptions of no of loci/environmental role
-
Not concerned about penetrence
-
Assumed diseased individuals have alleles in common
Questão 32
Responda
-
Identical by state
-
Identical by descent
Questão 33
Responda
-
Identical by state
-
Identical by descent
Questão 34
Questão
What is used in Non-Parametric Linkage Analysis to indicate linkage?
Responda
-
Deviation from normal ratios of sibling inheritence
-
Deviation for normal ratio's of phenotype expression
-
Deviation from normal allelic ratios
Questão 35
Questão
Chron's disease occurs in 1-3/10,000 people
Responda
- True
- False
Quer criar seus próprios Quizzes gratuitos com a GoConqr? Saiba mais.