4614882
Descrição
Quiz por MatthewEllis96, atualizado more than 1 year ago
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Criado por MatthewEllis96
quase 9 anos atrás
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Questão 1
Questão
Which of these is not a function of blood?
Responda
-
Transport of nutrients
-
Transport of signals (hormones etc)
-
Heat distribution
-
Hormone production
Questão 2
Questão
Which of these inorganic ions are not found in plasma?
Responda
-
Na+
-
Cl-
-
K+
-
Mg2+
Questão 3
Questão
Which of these is not a component of plasma?
Responda
-
Water
-
Small organics
-
Proteins
-
Red blood cells
Questão 4
Questão
How much water is contained in plasma?
Responda
-
5-5.5L
-
5.5-6L
-
4.5-5L
-
6-6.5L
Questão 5
Questão
Which is the most abundant serum protein?
Responda
-
Albumin
-
α1-globulins
-
β-globulins
-
γ-globulins
Questão 6
Questão
What is the normal range of protein concentration in serum?
Responda
-
60-80 g/L
-
50-70 g/L
-
70-90 g/L
-
40-60 g/L
Questão 7
Questão
What are the approximate proportions of Albumin?
Responda
-
~55%
-
~60%
-
~50%
-
~65%
Questão 8
Questão
What is the approximate proportion of immunoglobulin G?
Responda
-
~15%
-
~20%
-
~10%
-
~25%
Questão 9
Questão
Which of these is not involved in blood clotting?
Responda
-
Albumin
-
Thrombin
-
Fibrin
-
Plasmin
Questão 10
Questão
Which of these is a 66kDa polypeptide with 3 homologous domains each with different binding sites?
Responda
-
Albumin
-
α1-Proteinase Inhibitor
-
Transferrin
-
Haemoglobin
Questão 11
Questão
Which of the following is a 54kDa polypeptide with a 'bait' sequence for elastase binding?
Responda
-
α1-Proteinase Inhibitor
-
Albumin
-
Transferrin
-
Haemoglobin
Questão 12
Questão
Which of the following is a 77kDa polypeptide with 2 homologous domains each with an Fe binding site
Responda
-
Transferrin
-
Albumin
-
α1-Proteinase Inhibitor
-
Haemoglobin
Questão 13
Questão
Which of the following is not a Granulocyte
Responda
-
Neutrophils
-
Eiosinophils
-
Basophils
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Lymphocytes
Questão 14
Questão
How many molecules of Haemoglobin are there in a red blood cell?
Responda
-
250x10^6
-
250x10^8
-
250x10^7
-
250x10^5
Questão 15
Questão
Which of the following is not present in a red blood cell?
Responda
-
Mitochondria
-
Cytoskeleton
-
Haemoglobin
-
Cell Membrane
Questão 16
Questão
Which of the following is a 64kDa tetrapolypeptide with 2 α-chains and 2 β-chains?
Responda
-
Haemoglobin
-
Albumin
-
Transferrin
-
α1-Proteinase Inhibitor
Questão 17
Questão
What percentage of humans have a Haemoglobin mutation?
Responda
-
1%
-
5%
-
7%
-
9%
Questão 18
Questão
Which of the following is not a main role of pattern recognition receptors?
Responda
-
To activate the cell to synthesise
-
To cause cells to release defensive molecules
-
To initiate phagocytosis or apoptosis
-
To carry out phagocytosis or apoptosis
Questão 19
Questão
Which of the following carries out phagocytosis
Responda
-
Neutrophils
-
Lymphocytes
-
Basophils
-
Eosinophils
Questão 20
Questão
Which of the following is not an anti microbial enzyme?
Responda
-
Lysozyme
-
Lacoperioxidase
-
Phopholipase A2
-
Superoxide dismutase
Questão 21
Questão
What is the size of anti-microbial peptides?
Responda
-
3-5kDa
-
2-4kDa
-
4-6kDa
-
5-7kDa
Questão 22
Questão
Which of the following is not an anti-microbial peptide?
Responda
-
Defensins
-
Histatins
-
Cathelicidins
-
Transferrins
Questão 23
Questão
Which of the following is not a feature of adaptive immunity?
Responda
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Specificity
-
Memory
-
Tolerance
-
Rapid 1st Response
Questão 24
Questão
Which of the following is regarded as a type of lympocyte
Responda
-
B cell
-
T cell
-
Both B and T cell
-
Neither B or T cell
Questão 25
Questão
In vaccination, which of these methods is not used?
Responda
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Using a related organism
-
Using a wild type strain
-
Using a recombinent antigen
-
Using an attenuated strain
Questão 26
Questão
Which of the following is a 150kDa tetrapolypeptide with 2 heavy amd 2 light chains
Responda
-
IgG
-
Haemoglobin
-
Albumin
-
Transferrin
Questão 27
Questão
IgG is made up of...
Responda
-
2 50kDa chains and 2 25kDa chains
-
1 75kDa chain and 3 25kDa chains
-
2 75kDa chains
-
3 50kDa chains
Questão 28
Questão
Which of these is a correct arrangement for polypeptide chains in IgG
Responda
-
γ2λ2
-
λ2κ2
-
γ2κλ
-
γ2γ2
Questão 29
Questão
How many Complementary-Determining Regions are there in a IgG molecule?
Responda
-
12
-
10
-
8
-
6
Questão 30
Questão
Which of the following contains 2 heavy chains (α) and two light chains (λ or κ)
Responda
-
IgA
-
IgM
-
IgD
-
IgE
Questão 31
Questão
Which of the following has 2 heavy chains (µ) and two light chains (λ or κ)
Responda
-
IgA
-
IgM
-
IgD
-
IgE
Questão 32
Questão
Which of the following has 2 heavy chains (δ) and two light chains (λ or κ)
Responda
-
IgA
-
IgM
-
IgD
-
IgE
Questão 33
Questão
Which of the following has 2 heavy chains (ε) and two light chains (λ or κ)
Responda
-
IgA
-
igD
-
IgM
-
IgE
Questão 34
Questão
The V domains on all the heavy chains are specified by
Responda
-
V segment
-
V and D segments
-
V, D and J segments
-
V and J segments
Questão 35
Questão
The V domains on all the light chains are specified by
Responda
-
V segment
-
V and D segments
-
V, D and J segments
-
V and J segments
Questão 36
Questão
Which of the following is false regarding Antibody-mediated immunity?
Responda
-
Directed towards extracellular antigens.
-
Recognition by BCRs on the B-cells.
-
Requires confirmation by Th-cells for antibody production
-
Directed towards intracellular antigens.
Questão 37
Questão
Which of the following statements regarding the MHC I and MHC II systems is false?
Responda
-
The are both highly polymorphic.
-
Both require 3 types of peptides
-
Individuals commonly have the same combination of MHC proteins
-
The binding sites of the MHC proteins recognise sets of peptides
Questão 38
Questão
Which of the following statements regarding T-cells is false?
Responda
-
From bone marrow
-
Mature in bone marrow
-
There are two types
-
Mature T-cells circulate and reside in lymphoid tissue
Questão 39
Questão
Which of the following statements is false?
Responda
-
All mitochondria come from the mother
-
Mitochondria have their own DNA
-
Mitochondria is found in all cell types
-
Mitochondria is involved with apoptosis
Questão 40
Questão
The body daily produces approximately...
Responda
-
70kg ATP
-
60kg ATP
-
80kg ATP
-
100kg ATP
Questão 41
Questão
What % of mitochondrial disorders are due to mtDNA mutations?
Responda
-
10
-
15
-
20
-
25
Questão 42
Questão
Which of the following statements regarding mtDNA is false?
Responda
-
Contains no introns
-
Contains a repair mechanism
-
Contains no repeats
-
Double stranded, circular
Questão 43
Questão
Which of the following can't be used for mitochondrial disease diagnosis
Responda
-
Maternal family history
-
Blood/CSF/Urine tests
-
Imaging Techniques
-
Paternal family history
Questão 44
Questão
Which mitochondrial disease has a very early onset of symptoms?
Responda
-
Leigh Syndrome
-
Leber's hereditary optic neuropathy
-
MELAS
-
Ophthalmoplegia
Questão 45
Questão
Which disorder is associated with "Ragged Red Fibers"
Responda
-
MERRF
-
NARP
-
MELAS
-
Pearson syndrome
Questão 46
Questão
Which of the following is not a radical?
Responda
-
Hydrogen peroxide
-
Hypoclorite
-
Singlet oxygen
-
Peroxynitrite
Questão 47
Questão
Which is the most reactive intermediate?
Responda
-
Hydroxyl radicals
-
Superoxide
-
Hydrogen Peroxide
-
Peroxynitrite
Questão 48
Questão
Which is the least reactive intermediate?
Responda
-
Hydrogen peroxide
-
Hydroxyl radicals
-
Superoxide
-
Peroxynitrite
Questão 49
Questão
Which is not a source of superoxide?
Responda
-
Enzymatic
-
Toxic compounds
-
Ionising Radiation
-
UV light
Questão 50
Questão
What enzyme is used to detoxify hydrogen peroxide?
Responda
-
Catalase
-
Superoxide dismutase
-
Hydrogen peroxidase
-
Hydrogen dismutase
Questão 51
Questão
(From Textbook) The production of antibodies in response to a foreign molecule is referred to as
Responda
-
a cellular immune response
-
a humoral immune response
-
an autoimmune response
Questão 52
Questão
(From textbook) An epitope is
Responda
-
the portion of an antibody which recognizes an antigen.
-
the protein of an antigen recognized by an antibody.
-
an internal signal in the B-lymphocytes initiating the production of antibodies.
Questão 53
Questão
(From textbook) The treatment of immunoglobulin G with papain results in the production of two types of fragments. Which of the following correctly relates these fragments to antigen binding?
Responda
-
The Fab fragment is capable of binding antigen but the Fc fragment is not.
-
The Fab fragment can bind antigen only in the presence of the Fc fragment.
-
The proteolytic action of papain abolishes the ability of the antibody fragments to bind antigen.
Questão 54
Questão
(From textbook) The immunoglobulin G molecule is composed of two heavy (H) and two light (L) chains. Which of the following is true regarding the relationship between these two types of chains and the Fab and Fc fragments?
Responda
-
The L chains are present only in the Fab fragment
-
The Fc fragment contains parts of both the H and L chains
-
Disulfide bonds linking H and L chains are found in both Fab and Fc fragments.
Questão 55
Questão
(From textbook) Hypervariable loops of the Fab portion of antibody molecules are involved in antigen binding. The amino acids forming these loops
Responda
-
come from the L chain only.
-
come from the H chain only.
-
come from both the H and L chains.
Questão 56
Questão
(From textbook) Genes for specific immunoglobulins are the product of rearrangement and linkage of V (variable) and C (constant) genes in the differentiation of lymphocytes. How does this process differ for the H and L chains?
Responda
-
J (joining) genes are used to link V and C genes in construction of genes for L chains but not H chains.
-
D (diversity) genes are used in place of J genes in construction of genes for H chains.
-
D (diversity) genes are used in conjunction with J genes in construction of genes for H chains.
Questão 57
Questão
(From textbook) T-cells scan the surface of cells and kill those that exhibit foreign markings. The form in which such cells are marked is
Responda
-
by proteins from intracellular pathogens being secreted by the target cells
-
by proteolytic products of intracellular pathogens being released from the target cells
-
by proteolytic products of intracellular pathogens being presented on the surface of the cells bound to the major histocompatibility complex.
Questão 58
Questão
(From textbook) Helper T cells also recognize foreign peptides displayed on the surface of cells in a complex with Class II MHC proteins. These peptides are the result of
Responda
-
degradation of an internal pathogen located in the cytosol.
-
degradation of proteins internalized by endocytosis.
-
foreign proteins being degraded by extracellular proteases
Questão 59
Questão
(From textbook) The human immunodeficiency virus (HIV) responsible for acquired autoimmune deficiency syndrome (AIDS) subverts the immune system by destroying what type of cell?
Responda
-
B-lymphocytes
-
killer T cells
-
helper T cells
Questão 60
Questão
(From textbook) Thymocytes are produced in the bone marrow and converted to T cells in the thymus. Which of the following is NOT a selective process involved in this conversion?
Responda
-
Positive selection to assure that only T cells that bind MHC proteins will survive.
-
Negative selection to assure that T cells that bind MHC proteins too tightly will be destroyed.
-
Selection to assure that T cells bind to MHC proteins only in the presence of foreign peptides.
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