Questão 1
Questão
What stimulates the secretion of the CA's?
Questão 2
Questão
Once the membrane has been depolarised, what voltage gated channels open?
Questão 3
Questão
The influx of ions into the cell signals secretion by exocytosis
Questão 4
Questão
What is stored in Catecholamine vesicles, along with the CA?
Responda
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ATP
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ADP
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Fromogranin
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Chromogranin
Questão 5
Questão
ATP is -ve at body pH, whilst CA's are +ve
Questão 6
Questão
Why are CA's stored with these other substances?
Responda
-
They keep the CA's out of solution
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They keep the CA's in solution
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Which helps prevent vesicle lysis due to osmotic pressure
Questão 7
Questão
ATP can also act as a neurotransmitter
Questão 8
Questão
When concentrations of CA in the synapse are low, Alpha2 Adrenergic receptors are activated,
Questão 9
Questão
B2 receptors _ adenylate cyclase, which _ the production of cAMP, which _ the influx of ions
Responda
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Stimulates, increases, increases
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Stimulates, increases, decreases
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Inhibits, increases, increases
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Inhibits, decreases, decreases
Questão 10
Questão
A2 adrenergic receptors have the opposite effect of B2 adrenergic receptors
Questão 11
Questão
Re-uptake Method 1 is presynaptic, and mediated by what?
Responda
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Active transport
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Diffusion
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A Na+/K+ pump
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Na+ channel
Questão 12
Questão
Uptake Method 2 is extraneuronal and is used to...
Responda
-
Destroy excess adrenaline
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Secrete adrenaline into the bloodstream
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Stimulate separate neurones
Questão 13
Questão
Monoamine oxidase is found in the RER and interacts with cytoplasmic neurotransmitter
Questão 14
Questão
What is the role of monoamine oxidase (3 steps)?
Responda
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Converts the amine --> aldehyde
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Reduction of Aldehyde --> Acid
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Reduction of Aldehyde --> Alcohol
Questão 15
Questão
Which enzyme uses S-Adenosty Methionine to methylate Neurotransmitters?
Questão 16
Questão
What is the final produce of the Oxidative pathway of Monoamine Oxidase?
Questão 17
Questão
What is the final produce of the Reductive pathway of Monoamine Oxidase?
Questão 18
Questão
In peripheral tissue, the oxidative pathway predominates. In the brain, the reduction pathway predominates.