Mastzelldegranulation

Mastzelldegranulation

Targets:Adenosinrezeptor A3Histamin-Rezeptor H4Cannabis??Benzodiazepin??

Mastzelldegranulation - Phytotherapie

 Inhibition1. Kim, H. M. et al. Inhibitory effect of mast cell-mediated immediate-type allergic reactions by sulfapyridine. Immunopharmacol Immunotoxicol 22, 253–266 (2000). 2. Shin, T. Y. et al. Inhibitory effect of mast cell-mediated immediate-type allergic reactions in rats by Perilla frutescens. Immunopharmacol Immunotoxicol 22, 489–500 (2000). 3. Kim, H. M., Lee, E. H., Cho, H. H. & Moon, Y. H. Inhibitory effect of mast cell-mediated immediate-type allergic reactions in rats by spirulina. Biochem. Pharmacol. 55, 1071–1076 (1998). 4. Kobayashi, Y. et al. Inhibitory effects of geranium essential oil and its major component, citronellol, on degranulation and cytokine production by mast cells. Biosci. Biotechnol. Biochem. 80, 1172–1178 (2016).

1.Migalovich-Sheikhet H, Friedman S, Mankuta D, Levi-Schaffer F. 2012. Novel identified receptors on MC. Front in Immunol 3:238.2.Lacotte S, Brun S, Muller S, Dumortier H. 2009. CXCR3, inflammation, and autoimmune diseases. Ann N Y Acad Sci. 1173:310-7.3.Akdis M, Burgler S, Crameri R, Eiwegger T, Fujita H, Gomez E, Klunker S, Meyer N, O’Mahony L, PalomaresO, Rhyner C, Ouaked N, Schaffartzik A, vandeVeen W, Zeller S, Zimmermann M, and Akdis C.A. 2011. Interleukins, from1to37, andinterferon-gamma: receptors, functions, and roles in diseases. J. AllergyClin.Immunol. 127:701–21.4.Gibbs BF and Levi-Schaffer F. 2012. H₄ receptors in mast cells and basophils: a new therapeutic target for allergy? Front Bio Sci. 17:430-7.5.Supajatura V, Ushio H, Nakao A, Akira S, Okumura K, Ra C, Ogawa H. 2002. Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity. J Clin Invest. 109(10):1351-9.6.Bulanova E, and Bulfone-Paus S. 2010. P2 receptor-mediated signaling in mast cell biology. Purinergic Signal. 6(1):3-17.

7.Nunomura S, Gon Y, Yoshimaru T, Kashiwakura J, Kawakami T, Ra C. 2010. FcepsilonRI beta-chain ITAM amplifies PI3K-signaling to ensure synergistic degranulation response via FcepsilonRI and adenosine receptors. Eur J Immunol. 40(4):1205-17.8.Aye CC, Toda M, Morohoshi K, Ono SJ. 2012. Identification of genes and proteins specifically regulated by costimulation of mast cell Fcε Receptor I and chemokine receptor 1. Exp Mol Pathol. 92(3):267-74.9.Elishmereni M and Levi- Schaffer F. 2011. CD48: A co-stimulatory receptor of immunity. Int J Biochem Cell Biol. 43(1):25-8.10.Shin JS, Abraham SN. 2001. Glycosylphosphatidylinositol-anchored receptor-mediated bacterial endocytosis. FEMS Microbiol Lett. 13;197(2):131-8.11.Malaviya R, Gao Z, Thankavel K, van der Merwe PA, Abraham SN. 1999. The mast cell tumor necrosis factor alpha response to FimH-expressing Escherichia coli is mediated by the glycosylphosphatidylinositol-anchored molecule CD48. Proc Natl Acad Sci U S A. 96(14):8110-5.

Publications

12.Malaviya R, Abraham SN.2001. Mast cell modulation of immune responses to bacteria. Immunol Rev. 179:16-24.13.Proft T, Baker EN. 2009. Pili in Gram-negative and Gram-positive bacteria - structure, assembly and their role in disease. Cell Mol Life Sci. 66(4):613-35.

14.Muñoz S, Hernández-Pando R, Abraham SN, Enciso JA.2003. Mast cell activation by Mycobacterium tuberculosis: mediator release and role of CD48. J Immunol. 170(11):5590-6.15.Rocha-de-Souza CM, Berent-Maoz B, Mankuta D, Moses AE, Levi-Schaffer F. 2008. Human mast cell activation by Staphylococcus aureus: interleukin-8 and tumor necrosis factor alpha release and the role of Toll-like receptor 2 and CD48 molecules. Infect Immun. 76(10):4489-97.16.Elishmereni M, Alenius HT, Bradding P, Mizrahi S, Shikotra A, Minai-Fleminger Y, Mankuta D, Eliashar R, Zabucchi G, Levi-Schaffer F. 2011. Physical interactions between mast cells and eosinophils: a novel mechanism enhancing eosinophil survival in vitro. Allergy. 66(3):376-85.17.Zimmermann N, King NE, Laporte J, Yang M, Mishra A, Pope SM, Muntel EE, Witte DP, Pegg AA, Foster PS, Hamid Q, Rothenberg ME. 2003. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest. 111(12):1863-74.18.Munitz A, Bachelet I, Finkelman FD, Rothenberg ME, Levi-Schaffer F. 2007. CD48 is critically involved in allergic eosinophilic airway