Copy and Edit

1807NRS Safe Administration of Medications 1

Description

End of Trimester 2, 2017 Quiz
Kathleen Jackson
Quiz by Kathleen Jackson, updated more than 1 year ago
Kathleen Jackson
Created by Kathleen Jackson about 7 years ago
226
1
0

Resource summary

Question 1

Question
Pharmacokinetics is:
Answer
  • The study of biological and therapeutic effects of drugs
  • The study of absorption, distribution, metabolism and excretion of drugs
  • The study of mechanisms of drug action
  • The study of methods of new drug development

Question 2

Question
What does “pharmacokinetics” include?
Answer
  • Complications of drug therapy
  • Drug biotransformation in the organism
  • Influence of drugs on metabolism processes
  • Influence of drugs on genes

Question 3

Question
What does “pharmacokinetics” include?
Answer
  • Pharmacological effects of drugs
  • Unwanted effects of drugs
  • Chemical structure of a medicinal agent
  • Distribution of drugs in the organism

Question 4

Question
The main mechanism of most drugs absorption in GI tract is:
Answer
  • Active transport (carrier-mediated diffusion)
  • Filtration (aqueous diffusion)
  • Endocytosis and exocytosis
  • Passive diffusion (lipid diffusion)

Question 5

Question
What kind of substances can’t permeate membranes by passive diffusion?
Answer
  • Lipid-soluble
  • Non-ionized substances
  • Hydrophobic substances
  • Hydrophilic substances

Question 6

Question
A hydrophilic medicinal agent has the following property:
Answer
  • Low ability to penetrate through the cell membrane lipids
  • Penetrate through membranes by means of endocytosis
  • Easy permeation through the blood-brain barrier
  • High reabsorption in renal tubules

Question 7

Question
What is implied by «active transport»?
Answer
  • Transport of drugs trough a membrane by means of diffusion
  • Transport without energy consumption
  • Engulf of drug by a cell membrane with a new vesicle formation
  • Transport against concentration gradient

Question 8

Question
What does the term “bioavailability” mean?
Answer
  • Plasma protein binding degree of substance
  • Permeability through the brain-blood barrier
  • Fraction of an uncharged drug reaching the systemic circulation following any route administration
  • Amount of a substance in urine relative to the initial doze

Question 9

Question
The reasons determining bioavailability are:
Answer
  • Rheological parameters of blood
  • Amount of a substance obtained orally and quantity of intakes
  • Extent of absorption and hepatic first-pass effect
  • Glomerular filtration rate

Question 10

Question
Pick out the appropriate alimentary route of administration when passage of drugs through liver is minimised:
Answer
  • Oral
  • Transdermal
  • Rectal
  • Intraduodenal

Question 11

Question
Which route of drug administration is most likely to lead to the first-pass effect?
Answer
  • Sublingual
  • Oral
  • Intravenous
  • Intramuscular

Question 12

Question
What is characteristic of the oral route?
Answer
  • Fast onset of effect
  • Absorption depends on GI tract secretion and motor function
  • A drug reaches the blood passing the liver
  • The sterilisation of medicinal forms is obligatory

Question 13

Question
Tick the feature of the sublingual route:
Answer
  • A drug has a pretty fast absorption
  • A drug is exposed to gastric secretion
  • A drug is exposed more prominent liver metabolism
  • A drug can be administrated in a variety of doses

Question 14

Question
Pick out the parenteral route of medicinal agent administration:
Answer
  • Rectal
  • Oral
  • Sublingual
  • Inhalation

Question 15

Question
Parenteral administration:
Answer
  • Cannot be used with unconsciousness patients
  • Generally results in a less accurate dosage than oral administration
  • Usually produces a more rapid response than oral administration
  • Is too slow for emergency use

Question 16

Question
What is characteristic of the intramuscular route of drug administration?
Answer
  • Only water solutions can be injected
  • Oily solutions can be injected
  • Opportunity of hypertonic solution injections
  • The action develops slower, than at oral administration

Question 17

Question
Intravenous injections are more suitable for oily solutions:
Answer
  • True
  • False

Question 18

Question
Correct statements listing characteristics of a particular route of drug administration include all of the following EXCEPT:
Answer
  • Intravenous administration provides a rapid response
  • Intramuscular administration requires a sterile technique
  • Inhalation provides slow access to the general circulation
  • Subcutaneous administration may cause local irritation

Question 19

Question
Most of drugs are distributed homogeneously.
Answer
  • True
  • False

Question 20

Question
Biological barriers include all except:
Answer
  • Renal tubules
  • Cell membranes
  • Capillary walls
  • Placenta

Question 21

Question
What is the reason of complicated penetration of some drugs through brain-blood barrier?
Answer
  • High lipid solubility of a drug
  • Meningitis
  • Absence of pores in the brain capillary endothelium
  • High endocytosis degree in a brain capillary

Question 22

Question
The volume of distribution (Vd) relates:
Answer
  • Single to a daily dose of an administrated drug
  • An administrated dose to a body weight
  • An uncharged drug reaching the systemic circulation
  • The amount of a drug in the body to the concentration of a drug in plasma

Question 23

Question
For the calculation of the volume of distribution (Vd) one must take into account:
Answer
  • Concentration of a substance in plasma
  • Concentration of substance in urine
  • Therapeutical width of drug action
  • A daily dose of drug

Question 24

Question
A small amount of the volume of distribution is common for lipophylic substances easy penetrating through barriers and widely distributing in plasma, interstitial and cell fluids:
Answer
  • True
  • False

Question 25

Question
The term “biotransformation” includes the following:
Answer
  • Accumulation of substances in a fat tissue
  • Binding of substances with plasma proteins
  • Accumulation of substances in a tissue
  • Process of physicochemical and biochemical alteration of a drug in the body

Question 26

Question
Biotransformation of the drugs is to render them:
Answer
  • Less ionized
  • More pharmacologically active
  • More lipid soluble
  • Less lipid soluble

Question 27

Question
Tick the drug type for which microsomal oxidation is the most prominent:
Answer
  • Lipid soluble
  • Water soluble
  • Low molecular weight
  • High molecular weight

Question 28

Question
Pick out the right statement:
Answer
  • Microsomal oxidation always results in inactivation of a compound
  • Microsomal oxidation results in a decrease of compound toxicity
  • Microsomal oxidation results in an increase of ionization and water solubility of a drug
  • Microsomal oxidation results in an increase of lipid solubility of a drug thus its excretion from the organism is facilitated

Question 29

Question
Stimulation of liver microsomal enzymes can:
Answer
  • Require the dose increase of some drugs
  • Require the dose decrease of some drugs
  • Prolong the duration of the action of a drug
  • Intensify the unwanted reaction of a drug

Question 30

Question
Metabolic transformation (phase 1) is:
Answer
  • Acetylation and methylation of substances
  • Transformation of substances due to oxidation, reduction or hydrolysis
  • Glucuronide formation
  • Binding to plasma proteins

Question 31

Question
Biotransformation of a medicinal substance results in:
Answer
  • Faster urinary excretion
  • Slower urinary excretion
  • Easier distribution in organism
  • Higher binding to membranes

Question 32

Question
Conjugation is:
Answer
  • Process of drug reduction by special enzymes
  • Process of drug oxidation by special oxidases
  • Coupling of a drug with an endogenous substrate
  • Solubilization in lipids

Question 33

Question
Which of the following processes proceeds in the second phase of biotransformation?
Answer
  • Acetylation
  • Reduction
  • Oxidation
  • Hydrolysis

Question 34

Question
Metabolic transformation and conjugation usually results in an increase of a substance biological activity:
Answer
  • True
  • False

Question 35

Question
In case of liver disorders accompanied by a decline in microsomal enzyme activity the duration of action of some drugs is:
Answer
  • Decreased
  • Enlarged
  • Remained unchanged
  • Changed insignificantly

Question 36

Question
Half life (t ½) is the time required to:
Answer
  • Change the amount of a drug in plasma by half during elimination
  • Metabolize a half of an introduced drug into the active metabolite
  • Absorb a half of an introduced drug
  • Bind a half of an introduced drug to plasma proteins

Question 37

Question
Half life (t ½) doesn’t depend on:
Answer
  • Biotransformation
  • Time of drug absorption
  • Concentration of a drug in plasma
  • Rate of drug elimination

Question 38

Question
Elimination is expressed as follows:
Answer
  • Rate of renal tubular reabsorption
  • Clearance speed of some volume of blood from substance
  • Time required to decrease the amount of drug in plasma by one-half
  • Clearance of an organism from a xenobiotic

Question 39

Question
The most rapid eliminated drugs are those with high glomerular filtration rate and actively secreted but aren’t passively reabsorbed:
Answer
  • True
  • False

Question 40

Question
Systemic clearance (CLs) is related with:
Answer
  • Only the concentration of substances in plasma
  • Only the elimination rate constant
  • Volume of distribution, half life and elimination rate constant
  • Bioavailability and half life
Show full summary Hide full summary

Want to create your own Quizzes for free with GoConqr? Learn more.

Similar

Nervous System
4everlakena
Diabetes Mellitus
Kirsty Jayne Buckley
Renal System A&P
Kirsty Jayne Buckley
Oxygenation
Jessdwill
Clostridium Difficile
Kirsty Jayne Buckley
Definitions
katherinethelma
Clinical Governance
Kirsty Jayne Buckley
CMS Interpretive Guidelines for Complaint/Grievances
Lydia Elliott, Ed.D
NCLEX RN SAMPLE TEST
MrPRCA
NURS 310 EXAM 1 PRACTIC EXAM
harlacherha
Skin Integrity and Wound Care
cpeters
Browse Library