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1807NRS Safe Administration of Medications 2

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Nursing Quiz on 1807NRS Safe Administration of Medications 2, created by Kathleen Jackson on 01/10/2017.
Kathleen Jackson
Quiz by Kathleen Jackson, updated more than 1 year ago
Kathleen Jackson
Created by Kathleen Jackson about 7 years ago
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Resource summary

Question 1

Question
Pharmacodynamics involves the study of following EXCEPT:
Answer
  • Biological and therapeutic effects of drugs
  • Absorption and distribution of drugs
  • Mechanisms of drug action
  • Drug interactions

Question 2

Question
Pharmacodynamics involves the study of following?
Answer
  • Mechanisms of drug action
  • Biotransformation of drugs in the organism
  • Distribution of drugs in the organism
  • Excretion of drug from the organism

Question 3

Question
Pharmacodynamics involves the following?
Answer
  • Information about main mechanisms of drug absorption
  • Information about unwanted effects
  • Information about biological barriers
  • Information about excretion of a drug from the organism

Question 4

Question
Pick out the answer which is the most appropriate to the term “receptor”
Answer
  • All types of ion channels modulated by a drug
  • Enzymes of oxidizing-reducing reactions activated by a drug
  • Active macromolecular components of a cell or an organism which a drug molecule has to combine with in order to elicit its specific effect
  • Carriers activated by a drug

Question 5

Question
What does “affinity” mean?
Answer
  • A measure of how tightly a drug binds to plasma proteins
  • A measure of how tightly a drug binds to a receptor
  • A measure of inhibiting potency of a drug
  • A measure of bioavailability of a drug

Question 6

Question
Target proteins which a drug molecule binds are:
Answer
  • Only receptors
  • Only ion channels
  • Only carriers
  • All answers are correct

Question 7

Question
An agonist is a substance that:
Answer
  • Interacts with the receptor without producing any effect
  • Interacts with the receptor and initiates changes in cell function, producing various effects
  • Increases concentration of another substance to produce effect
  • Interacts with plasma proteins and doesn’t produce any effect

Question 8

Question
If an agonist can produce maximal effects and has high efficacy it’s called:
Answer
  • Partial agonist
  • Antagonist
  • Agonist-antagonist
  • Full agonist

Question 9

Question
If an agonist can produce submaximal effects and has moderate efficacy it’s called:
Answer
  • Partial agonist
  • Antagonist
  • Agonist-antagonist
  • Full agonist

Question 10

Question
An antagonist is a substance that:
Answer
  • Binds to the receptors and initiates changes in cell function, producing maximal effect
  • Binds to the receptors and initiates changes in cell function, producing submaximal effect
  • Interacts with plasma proteins and doesn’t produce any effect
  • Binds to the receptors without directly altering their functions

Question 11

Question
A competitive antagonist is a substance that:
Answer
  • Interacts with receptors and produces submaximal effect
  • Binds to the same receptor site and progressively inhibits the agonist response
  • Binds to the nonspecific sites of tissue
  • Binds to one receptor subtype as an agonist and to another as an antagonist

Question 12

Question
The substance binding to one receptor subtype as an agonist and to another as an antagonist is called:
Answer
  • Competitive antagonist
  • Irreversible antagonist
  • Agonist-antagonist
  • Partial agonist

Question 13

Question
Irreversible interaction of an antagonist with a receptor is due to:
Answer
  • Ionic bonds
  • Hydrogen bonds
  • Covalent bonds
  • All answers are correct

Question 14

Question
Mechanisms of transmembrane signaling are the following EXCEPT:
Answer
  • Transmembrane receptors that bind and stimulate a protein tyrosine kinase
  • Gene replacement by the introduction of a therapeutic gene to correct a genetic effect
  • Ligand-gated ion channels that can be induced to open or close by binding a ligand
  • Transmembrane receptor protein that stimulates a GTP-binding signal transducer protein (G-protein) which in turn generates an intracellular second messenger

Question 15

Question
Tick the second messenger of G-protein-coupled (metabotropic) receptor:
Answer
  • Adenylyl cyclase
  • Sodium ions
  • Phospholipase C
  • cAMP

Question 16

Question
Tick the substance which changes the activity of an effector element but doesn’t belong to second messengers:
Answer
  • cAMP
  • cGMP
  • G–protein
  • Calcium ions

Question 17

Question
Give the definition for a therapeutical dose:
Answer
  • The amount of a substance to produce the minimal biological effect
  • The amount of a substance to produce effects hazardous for an organism
  • The amount of a substance to produce the required effect in most patients
  • The amount of a substance to accelerate an increase of concentration of medicine in an organism

Question 18

Question
Pick out the correct definition of a toxic dose:
Answer
  • The amount of substance to produce the minimal biological effect
  • The amount of substance to produce effects hazardous for an organism
  • The amount of substance to produce the necessary effect in most of patients
  • The amount of substance to fast creation of high concentration of medicine in an organism

Question 19

Question
Which effect may lead to toxic reactions when a drug is taken continuously or repeatedly?
Answer
  • Refractoriness
  • Cumulative effect
  • Tolerance
  • Tachyphylaxis

Question 20

Question
What term is used to describe a decrease in responsiveness to a drug which develops in a few minutes?
Answer
  • Refractoriness
  • Cumulative effect
  • Tolerance
  • Tachyphylaxis

Question 21

Question
Idiosyncratic reaction of a drug is:
Answer
  • A type of hypersensitivity reaction
  • A type of drug antagonism
  • Unpredictable, inherent, qualitatively abnormal reaction to a drug
  • Quantitatively exaggerated response

Question 22

Question
Characteristic unwanted reaction which isn’t related to a dose or to a pharmacodynamic property of a drug is called:
Answer
  • Idiosyncrasy
  • Hypersensitivity
  • Tolerance
  • Teratogenic action

Question 23

Question
If two drugs with the same effect, taken together, produce an effect that is equal in magnitude to the sum of the effects of the drugs given individually, it is called as:
Answer
  • Antagonism
  • Potentiation
  • Additive effect
  • None of the answers are correct

Question 24

Question
What phenomenon can occur in case of using a combination of drugs?
Answer
  • Tolerance
  • Tachyphylaxis
  • Accumulation
  • Synergism

Question 25

Question
What is the type of drug-to-drug interaction which is the result of interaction at receptor, cell, enzyme or organ level?
Answer
  • Pharmacodynamic interaction
  • Physical and chemical interaction
  • Pharmaceutical interaction
  • Pharmacokinetic interaction

Question 26

Question
What is the type of drug-to-drug interaction which is connected with processes of absorption, biotransformation, distribution and excretion?
Answer
  • Pharmacodynamic interaction
  • Physical and chemical interaction
  • Pharmaceutical interaction
  • Pharmacokinetic interaction

Question 27

Question
The situation when failure to continue administering the drug results in serious psychological and somatic disturbances is called?
Answer
  • Tachyphylaxis
  • Sensibilization
  • Abstinence syndrome
  • Idiosyncrasy

Question 28

Question
Tolerance and drug resistance can be a consequence of:
Answer
  • Drug dependence
  • Increased metabolic degradation
  • Depressed renal drug excretion
  • Activation of a drug after hepatic first-pass

Question 29

Question
Tolerance and drug resistance can be a consequence of:
Answer
  • Change in receptors, loss of them or exhaustion of mediators
  • Increased receptor sensitivity
  • Decreased metabolic degradation
  • Decreased renal tubular secretion

Question 30

Question
Tolerance develops because of:
Answer
  • Diminished absorption
  • Rapid excretion of a drug
  • Both answers are correct
  • No answer is correct
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