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Clinical Immunology Final MCQs- 4th Year- PMU

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Clinical Immunology Final MCQs- 4th Year- PMU
Med Student
Quiz by Med Student , updated more than 1 year ago
Med Student
Created by Med Student over 5 years ago
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Question 1

Question
Which of the following methods is suitable for detectin of serum globulins?
Answer
  • Nephelometry
  • Radial immnodiffusion by manchini
  • Turbidimetry
  • NBT-test
  • The mantoux test

Question 2

Question
Type II allergic reations are realized by
Answer
  • anaphylaxis
  • complement-mediated cytolysis
  • immune complexes
  • infectious immunity

Question 3

Question
Monoclonal antibodies are
Answer
  • pure population of immunoglobulins with same structure ant antigen specifity
  • albumins that are coded from other group of genes
  • mixed population of immunoglobulins with same structure, but different antigen specifity
  • substrate causing expression of immunoglobulins from other class in B-cells

Question 4

Question
Which immunological method is not proper for detecting of specific IgE
Answer
  • Immuno-enzyme(ELİSA, immuno-blot technique)
  • Classical ones(agglutination, precuipitation)
  • Floucytometry
  • Chemilluminescence

Question 5

Question
Low levels of IgA are found in case of
Answer
  • allergic reaction
  • chronic granulamatosis disease
  • selective IgA deficit
  • macro-globulinemia

Question 6

Question
Auto immune disease due to antibodies could be a result of (point the wrong answer)
Answer
  • forming of antigen-antibody complexes
  • antibodies that blockade cell receptor
  • antibody-depended cell-mediated cytotocicitty(ADCC)
  • cell-mediated reaction

Question 7

Question
The name of resident macrophages in liver is
Answer
  • ostephages
  • lagerhance cells
  • kupfer cells
  • microglial

Question 8

Question
EBV can cause
Answer
  • Hepatoma
  • Nasopharyngeal carcinoma
  • Burkit lymphoma
  • Adenocaqrcinoma pulmonis

Question 9

Question
Which of the following indicators is the most important in case of detecting of immune status in AIDS
Answer
  • NBT test
  • Anti-DNA antibodies
  • CD4/CD8 index
  • The bence-jones protein

Question 10

Question
System lupus erythematosus
Answer
  • is caused by mutations in ds-DNA
  • is revealed with many symptoms and affects many organs
  • is an example of T-cell mediated disease
  • is a result of generating of immune complexes

Question 11

Question
The opsonisation is a process of
Answer
  • Ingestion and destruction of an antigen from phagocyte
  • Of covering of antigen with antibodies in purpose to ease phagocytosis
  • Of covering of antigen with complement in purpose to ease phagoytosis
  • Obtaining of monoclonal antibodies

Question 12

Question
Connect with arrows allergic diseases with relevant types allergic reactions: Type [blank_start]3[blank_end] - serum-disease Type [blank_start]4[blank_end] - contact dermatitis Type [blank_start]1[blank_end] - anaphylaxis Type [blank_start]2[blank_end]- hemolytic disease of newborn
Answer
  • 3
  • 1
  • 2
  • 4
  • 4
  • 1
  • 2
  • 3
  • 1
  • 2
  • 3
  • 4
  • 2
  • 1
  • 3
  • 4

Question 13

Question
The mature B-lymphocytes expresses onto their surface
Answer
  • IgM and IgD
  • IgM and IgA
  • IgD and IgE
  • IgG and IgD

Question 14

Question
The lymphocyte infiltration of thyroidea is typical for
Answer
  • The hashimoto thyroitidis
  • Euthyroid struma
  • Hemolytic anemia
  • Tuberculosis

Question 15

Question
The electrophoresis is
Answer
  • radial immunodiffusion in gel
  • separation of molecules in electric field
  • complement fixation reaction
  • electroimmunodiffusion

Question 16

Question
I type allergic reactions are
Answer
  • Immunocomplex
  • Cytotoxic
  • IgE mediated
  • Cell mediated

Question 17

Question
Connect with arrows autoimmune diseases from the left side with relevant characteristics from the right side: wide with relevant characteristics a. Multiple sclerosis [blank_start]6[blank_end] b. SLE [blank_start]4[blank_end] c. Myasthenia gravis [blank_start]5[blank_end] d. Pernicious anemia [blank_start]1[blank_end] e. Hashimoto thyoiditis [blank_start]2[blank_end] f. Hemolytic anemia [blank_start]3[blank_end] 1. autoantibodies against parietal cells of stomach ans intrinsic factor and as a result of this doesn't absorb Vitamin B12 2. autoantibodies against thyroglobuline and thyroid peroxidase 3. antibodies against epitopes of red blood cells 4. antibodies against nucleus antigens 5. antibodies against acetylcholine 6. antibodies against morbidly antigens in liquor and serum, depressed reactions of delayed type hypersensitivity against measles antigens
Answer
  • 6
  • 1
  • 2
  • 3
  • 4
  • 5
  • 4
  • 1
  • 2
  • 3
  • 5
  • 6
  • 5
  • 1
  • 2
  • 3
  • 4
  • 6
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 2
  • 1
  • 3
  • 4
  • 5
  • 6
  • 3
  • 1
  • 2
  • 4
  • 5
  • 6

Question 18

Question
The monoclonal antibodies, connected with diphtheria toxin could be used for
Answer
  • tumour diagnosis
  • immunostimulation
  • immunosupperession
  • immunotherapy of tumors

Question 19

Question
The defensins are
Answer
  • growth factors
  • antimicrobial peptides in granules of neutrophils
  • cytokines-mediators for immune response

Question 20

Question
What is the mechanism of III type allergic reactions
Answer
  • anaphylaxis
  • complement-mediated cytolsis
  • immune complexes
  • infectious immunity

Question 21

Question
Which of the following tumour markers are connected with melanoma maligna?
Answer
  • CA-15-3
  • gp 120
  • S100B
  • MART-1Melan A

Question 22

Question
Immuno-scintigraphy uses monoclonal antibodies against tumour antigen connected with
Answer
  • FITC
  • Rhodamine
  • Iodine 131, technetium
  • Enzyme

Question 23

Question
INF-γ is produced by
Answer
  • Activated T lymphocytes
  • Fibroblasts
  • B-lymphocytes
  • Leucocytes

Question 24

Question
What kind of auto-antibodies we find in patients with insulin-depended sugar diabetes?
Answer
  • Nucleus
  • Thyroid microsomes
  • IgG molecules
  • Island cells of pancreas

Question 25

Question
Rejection of a transplantant due to pre-forming antibodies in recipient is defined as
Answer
  • Hyper acute rejection
  • Accelerated
  • Acute
  • Chronic

Question 26

Question
What of the following possesses the most expressed oncogenic potential
Answer
  • Influenza virus type A
  • Ebola virus
  • EBV
  • Polioviruses 1,2 ,3
  • HPV

Question 27

Question
Is the following correct? Active immunity is a nospecific and is an ancient form of defense and lower degree of effectiveness?
Answer
  • True
  • False

Question 28

Question
Type IV allergic reactions are realized by means of
Answer
  • anaphylaxis
  • complement-mediated cytolysis
  • immune reactions
  • infectious immunity

Question 29

Question
True hypersensitivity reactions start usually after
Answer
  • 15-30 minutes
  • 48 hours

Question 30

Question
Which of the following characteristics does not belong to the Burkit lymphoma?
Answer
  • T-cell neoplasma
  • Is a non-hodgkin lymphoma
  • Has a connections with EBV
  • Is a B-cell lymphoma

Question 31

Question
Antigen presenting cells are
Answer
  • Dendrite cells and macrophages
  • T-lymphocytes
  • B-lymphocytes
  • Polymorphy-nuclear cells

Question 32

Question
We could use the mantoux test in diagnosis of (point two diseases) a- [blank_start]Tuberculosis[blank_end] b- [blank_start]Leprosy[blank_end]
Answer
  • Tuberculosis
  • Leprosy

Question 33

Question
Which of the following factors belong to the innate immunity?
Answer
  • Phagocytosis
  • T-lymphocytes
  • Complement, mucin, a-and b inferferons
  • Antibodies
  • Skin, mucus, normal flora
  • B-lymphocytes

Question 34

Question
What we could use as a subsrrate for detection of antinuclear antibodies throguh IFA?
Answer
  • rat liver
  • rat kidney
  • rat stomach
  • hep2 cell line

Question 35

Question
Which of the pointed immunological parameters is most important for detection of multiple myleoma?
Answer
  • NBT test
  • Anti-DNA antibodies
  • CD4/CD8 index
  • The Bence-jones protein

Question 36

Question
The most popular techniques for detection of antinuclear antibodies are
Answer
  • Agglutination
  • Indirect immunofluorescence
  • Neutralization test
  • The complement fixation test
  • ELISA
  • Direct immunofluorescence

Question 37

Question
CD3 molecule is a marker for
Answer
  • NK cells
  • Macrophages
  • Immunocompetent T lymphocytes
  • Mature B-lymphocytes

Question 38

Question
The accelerated reaction for rejection of transplantant is revealed
Answer
  • Intra-operative or immediately after operation
  • 24-to 72 hours after transplantation
  • Till the third month
  • 3 month after the transplantation

Question 39

Question
which of the following immunological indexes ids the most important for patients with chronic granulomatous disease?
Answer
  • NBT test
  • Anti DNA antibodies
  • CD4/CD8 index
  • The Bence-jones protein

Question 40

Question
CEA is increased in case of
Answer
  • nasopharyngeal carcinoma
  • the Burkit lymphoma
  • gatro-intestinal tumors
  • smokers

Question 41

Question
Which of the following is connected with damage of humoral immunity?
Answer
  • Di-George sydrome
  • Agamaglobulinemia of Bruton
  • Chronic candidosis of skin and mucus
  • Angioedema hereditaria

Question 42

Question
How many are complement activating ways?
Answer
  • one
  • three
  • two
  • four

Question 43

Question
The complement activation occurs via three pathways which are: 1. [blank_start]Classical[blank_end] pathway 2. [blank_start]Alternative[blank_end] pathway 3. [blank_start]Lectin[blank_end] pathway
Answer
  • Classical
  • Alternative
  • Lectin

Question 44

Question
The “respiratory burst" is related to
Answer
  • Humoral immunity
  • Cellular immunity
  • Phagocytosis
  • NK-cells function

Question 45

Question
The immune competence of T-lymphocytes is acquired in
Answer
  • Thyroidea
  • Bone marrow
  • Thymus
  • MALT

Question 46

Question
What expresses the CD8 molecule?
Answer
  • Macrophages
  • Antigen presenting cells
  • Cytotoxic T-lymphocytes
  • T- suppressors

Question 47

Question
What is human cell receptor for human immunodeficiency virus (HIV)?
Answer
  • CD3 molecule
  • CD8 molecule
  • CD4 molecule
  • CD19 molecule

Question 48

Question
Point the WRONG answer: Gamma interteron is produced by:
Answer
  • Non-activated macrophages and mastocytes
  • Leucocytes and Fibroblasts
  • Activated macrophages and NK cell
  • Lymphocytes

Question 49

Question
The determination of functional activity of the complement might be done by
Answer
  • Immune histochemical methods
  • Reaction neutratisation
  • CH50 test
  • Micro haemagglutination

Question 50

Question
CD4 molecule is situated on the surface of the
Answer
  • Monocytes
  • T-helpers
  • Cytotoxic T-lymphocytes
  • Plasmocytes

Question 51

Question
The presence of the antigen together with the MHC-II class molecules is realized by
Answer
  • Dendrite cells and macrophages
  • Cytotoxic T-lymphocytes
  • B-lymphocytes
  • Plasmocytes

Question 52

Question
A B-cell can synthesise some different antibodies with different species of the antigen
Answer
  • True
  • False

Question 53

Question
After the antigen stimulus the mature B-lymphocytes are transformed into
Answer
  • cytotoxic cell
  • immunocompetent cell
  • plasmocyte

Question 54

Question
What tests are for evaluation of the phagocytic activity?
Answer
  • Flow cytometry of detection of oxidative burst
  • Serum levels of immunoglobulins
  • CD4/CD8 index
  • NBT test

Question 55

Question
Paraproteinemias are detected in
Answer
  • Multiple myeloma
  • Reiter's Syndrome
  • Waldenstrom macroglobulinemia
  • Chronic lymphoid leukemia
  • SLE

Question 56

Question
Last cells, incapable to divide are
Answer
  • Plasmocytes
  • Neutrophils
  • T-lymphocytes
  • B-Iymphocytes

Question 57

Question
What do the mature B-lymphocytes express on their surface?
Answer
  • lgM and IgD
  • IgD ant IgE
  • IgM and IgA
  • IgG and IgD

Question 58

Question
How do CD8 eliminate their targets?
Answer
  • after recognition of antigen, connected with MCH-I class molecule
  • after recognition of antigen connected with MCH-II class molecule
  • via activation of an alternative way of complement
  • due releasing of interferon
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