Question 1
Question
A blood group has both A and B antigens but no antibodies, It is
Question 2
Question
A compound formed in an organism for inhibiting growth of another organism is
Answer
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Antigen
-
Antibody
-
Antibiotic
-
Antiallergic
Question 3
Question
A disease due to allergic reaction is
Answer
-
Enteric fever
-
Yellow fever
-
Hay fever
-
Trench fever
Question 4
Question
Which is involved in body defense?
Answer
-
Neutrophils
-
Macrophages
-
Lymphocytes
-
All the above
Question 5
Question
A doctor suggested to a couple not to have more than one child because of
Answer
-
Rh+ male Rh- female
-
Rh- male Rh+ female
-
Rh+ male Rh+ female
-
Rh- male Rh- female
Question 6
Question
A molecule that produces an immune response is
Answer
-
Antigen
-
Antibody
-
Carcinogen
-
Mutagen
Question 7
Question
A noninfectious unnatural and unusual reaction to a substance or condition is
Answer
-
Immunity
-
Allergy
-
Infection
-
Toxin
Question 8
Question
A person is injected with gammaglobulin against hepatitis B. It is
Answer
-
Artificially acquires passive immunity
-
Artificially acquires active immunity
-
Naturally acquires active immunity
-
Naturally acquires passive immunity
Question 9
Question
Acquired immunity as developed after vaccination or infection is found in
Question 10
Question
Acquired immunity is found in
Question 11
Question
Active immunity is due to
Answer
-
Suppressor T-cells
-
killer T-cells
-
Memory cells
-
Helper T-cells
Question 12
Question
Active immunity means
Question 13
Question
AIDS is caused by
Answer
-
RNA virus
-
DNA virus
-
Herpes virus
-
Hepatitis virus
Question 14
Question
An example of innate immunity is
Answer
-
T-lymphocytes
-
B-lymphocyte
-
Neutrophils
-
Thyroid cells
Question 15
Question
An insect bite may result in inflammation of that spot. It is triggered by alarm chemicals such as
Answer
-
Histamine and dopamine
-
Histamine and kinins
-
Interferon and opsonin
-
Interferons and histones
Question 16
Question
An Rh- individual receives Rh+ blood. The recipient becomes
Answer
-
Sterlite
-
Dead
-
No reaction
-
Isoimmunised
Question 17
Question
Which of the following are secondary lymphoid organs?
Answer
-
Spleen
-
Lymph Nodes
-
Thymus
-
Bone Marrow
-
Lymph Vessels
Question 18
Answer
-
2 light chains and two heavy chains joined by di-sulphide bond (H2L2)
-
2 light chains and two heavy chains joined by hydrogen bond (H2L2)
-
2 light chains and a heavy chain joined by di-sulphide bond (H1L2)
-
a light chain and two heavy chains joined by di-sulphide bond (H2L1)
Question 19
Question
Which is the Ig that first reaches the site of infection?
Question 20
Question
Which is the largest Ig?
Question 21
Question
Which of the following statements are true regarding IgM?
Answer
-
IgM is a pentamer and is the largest Ig and called as ‘natural antibody’
-
IgM exists as monomer on B-cell surface
-
IgM is involved in early primary immune response
-
all of these
Question 22
Question
Which of the following statements are true?
Answer
-
IgM is involved in primary immune response
-
IgG is involved in primary immune response
-
Both IgM and IgG are involved in primary immune response
-
IgG is involved only in secondary immune response
Question 23
Question
The antibody present in secretions like tears, saliva, colostrum is
Question 24
Question
The primary Ig of exocrine secretions is
Question 25
Answer
-
proteins
-
glycoproteins
-
carbohydrates
-
nucleic acid
Question 26
Question
The antigen binding site on an antibody is called:
Answer
-
endotope
-
paratope
-
epitope
-
antitope
Question 27
Answer
-
2 Fab regions and an Fc region
-
an Fab region and an Fc region
-
2 Fab regions and 2 Fc regions
-
many Fab regions and many Fc regions
Question 28
Question
The hypervariable region resides in the
Answer
-
N terminal region of light chain
-
N-terminal region of light and heavy chain
-
C-terminal region of light chain
-
C-terminal region of light chain and heavy chain
Question 29
Answer
-
fragment antibody binding
-
fragment antigen binding
-
fragment antibody or antigen binding
-
fragment affinity binding
Question 30
Question
Which of the following statement is true regarding Fc region?
Answer
-
fragment crystalisation and is the constant region
-
fragment constant and is the variable region
-
fragment crystalisation and is the variable region
-
fragment crystalisation and has both variable and constant region
Question 31
Answer
-
has a hypervariable region that binds with antibody
-
has a hypervariable region that binds with antigen
-
has a hypervariable region that binds with other immune cells
-
all of these
Question 32
Question
Fc region is involved in
Question 33
Question
The ability of antigen to stimulate antibody production is called
Answer
-
Affinity
-
Antigenicity
-
Elicitation
-
none of these
Question 34
Question
Clearance of antigens by antibodies involve
Question 35
Question
The two identical light chains of an antibody belongs to
Answer
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kappa only
-
lambda only
-
lambda or kappa
-
none of these
Question 36
Answer
-
proteins
-
carbohydrates
-
nucleic acids
-
all of these
Question 37
Question
A molecule that reacts with specific antibody but is not immunogenic by itself is called
Answer
-
carrier
-
antigen
-
hapten
-
immunogen
Question 38
Question
Haptens are immunogenic upon binding covalently to a carrier protein how?
Question 39
Question
Haptens cannot activate T cell or B cells due to:
Question 40
Question
Which of the following is a hapten?
Answer
-
Cyanide
-
Paracetamol
-
Penicillin
-
None of these
Question 41
Question
An incomplete antigens
Answer
-
are also called as haptens
-
are immunogenic upon binding covalently to a carrier protein
-
cannot induce antibody production by itself
-
all of the above
Question 42
Question
The second most abundant Ig is
Question 43
Question
The most effective Ig is:
Question 44
Answer
-
pentamer with 10 antigen binding sites
-
tetramer with 8 antigen binding sites
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monomer with 2 antigen binding sites
-
dimer with 4 antigen binding sites
Question 45
Question
The Ig that mediates allergic reaction is
Question 46
Question
The Ig involved in host defence against parasitic infection (helminths)
Question 47
Question
The bonds involved in antigen-antibody interactions are
Question 48
Question
Which of the following statement is true?
Answer
-
all immunogens are antigens but all antigens are not immunogens
-
all immunogens are antigens and all antigens are immunogens
-
all immunogens are not antigens but all antigens are immunogens
-
all immunogens are proteins and all proteins are immunogens
Question 49
Question
Which of the statements are true regarding antigen?
Answer
-
generally self-molecules and molecules with low molecular weight are non-immunogenic
-
an antigen generally has many epitopes
-
heteropolymers are more immunogenic than homopolymers
-
all of these
Question 50
Question
The process of removal and replacement of damaged tissues or organs with healthy ones from a donor is called as
Answer
-
transplantation
-
replacement therapy
-
repair and replacement
-
none of these
Question 51
Question
The transfer of individuals own tissue to another part of the body is called
Answer
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autograft
-
xenograft
-
allograft
-
syngeneic graft
Question 52
Question
The transfer of tissue between genetically identical individuals (like twins) is called
Answer
-
autograft
-
xenograft
-
allograft
-
syngeneic graft
Question 53
Question
The transfer of tissue between individuals of different species is called
Answer
-
autograft
-
xenograft
-
allograft
-
syngeneic graft
Question 54
Question
The transfer of tissue between genetically different individuals of same species is called
Answer
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autograft
-
xenograft
-
allograft
-
syngeneic graft
Question 55
Question
Which of the following has the maximum transplantation success rate?
Answer
-
autograft
-
xenograft
-
allograft
-
syngeneic graft
Question 56
Question
The major molecules responsible for rejection of transplant is
Answer
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B cells
-
T cells
-
MHC molecule
-
Antibodies
Question 57
Question
Which of the following statements are true regarding transplantation?
Answer
-
The compatibility of MHC proteins of donor and recipient will determine the success of transplantation
-
MHCs are just like fingerprints and all nucleated cells possess this fingerprint
-
The compatibility of MHC/HLA proteins of donor and recipient will be high if they are genetically closely related and may lead to successful transplantation.
-
all of these
Question 58
Question
In humans, MHC is called as
Question 59
Question
The genes for HLA proteins are clustered in the major histocompatibility complex located
Answer
-
on the short arm of chromosome 6
-
on the long arm of chromosome 6
-
on the short arm of chromosome 10
-
on the long arm of chromosome 10
Question 60
Question
The test that is done prior to transplantation surgery to determine the compatibility of MHC proteins between donor and recipient is called
Answer
-
MHC matching
-
MHC typing
-
tissue typing
-
blood HLA test
Question 61
Question
MHC class I is a cell surface molecule present on
Answer
-
B cells
-
All nucleated cells
-
APCs
-
T cells
Question 62
Question
MHC class II is a cell surface molecule present on
(most correct ans.)
Answer
-
B cells
-
All nucleated cells
-
APCs
-
T cells
Question 63
Question
Which of the following statements are true regarding complement activation?
Answer
-
lysis of pathogen, tumor cells and allografts
-
production of mediators that attracts neutrophils to the site of inflammation
-
opsonization
-
all of these
Question 64
Question
Complement system is involved in
Answer
-
specific defence
-
non-specific defence
-
both a and b
-
none of these
Question 65
Question
Allergy to penicillin is an example of
Question 66
Question
Type IV hypersensitivity is also called as:
Answer
-
immediate hypersensitivity
-
delayed hypersensitivity
-
cytotoxic hypersensitivity
-
immune complex hypersensitivity
Question 67
Question
The most common class of antibody involved in type II hypersensitivity is
Question 68
Question
T helper cell mediated hypersensitivity is:
Question 69
Question
Type III hypersensitivity is triggered by:
Question 70
Question
Autoimmune hemolytic anemia (AHA) is an example of
Question 71
Question
K cells and IgG mediated hypersensitivity is
Question 72
Question
Antibody dependent cytotoxicity is associated with
Question 73
Question
Allergies to sea foods, eggs etc is an example of
Question 74
Question
Humoral immunity is mediated by
Answer
-
B cells
-
macrophages
-
both a and b
-
phagocytes
Question 75
Question
Humoral immunity is also called as
Answer
-
antibody mediated immunity
-
non-specific immune response
-
antigen mediated immunity
-
all of these
Question 76
Question
B cell has receptor on its surface which is
Answer
-
monomeric IgM
-
dimeric IgM
-
monomeric IgG
-
B cell receptor
Question 77
Question
B cells upon activation by antigens
Question 78
Question
B cells differentiates to form
Question 79
Question
Which of the following statement is incorrect regarding plasma cells?
Answer
-
Plasma cells are the effector cells
-
Plasma cells secretes antibodies
-
The precursor of plasma cell is B cell
-
Plasma cell has surface receptors
Question 80
Question
Origin and maturation of B cells takes place at
Answer
-
lymph nodes
-
bone marrow
-
thymus
-
spleen
Question 81
Question
The function of memory B cell is
Question 82
Question
Generally antibodies produced against a pathogen is
Answer
-
monoclonal
-
homogenous
-
polyclonal
-
all of same specificity
Question 83
Question
Antibodies produced by plasma cells are
Question 84
Question
Antibodies clear out antigens by
Answer
-
neutralization
-
precipitation
-
agglutination
-
all of these
Question 85
Answer
-
opsonins
-
lipoproteins
-
serum phagocytes
-
none of these
Question 86
Question
Any substance that promotes phagocytosis of antigens by binding to them are called as
Answer
-
interleukins
-
macrophages
-
phagocytes
-
opsonins
Question 87
Question
The phenomenon of selective proliferation of B cells in response to their interaction with the antigen is called
Answer
-
clonal expansion
-
monoclonal selection
-
clonal proliferation
-
clonal selection
Question 88
Question
The specific targeted responses constitute the third line of defense in response to an infectious agent and is called as
Answer
-
third line of defence
-
adaptive immunity
-
acquired immunity
-
all of these
Question 89
Question
The characteristics of adaptive immunity include
Question 90
Question
Which of the cells are involved in adaptive immunity?
Answer
-
B cells and T cells
-
B cells only
-
T cells only
-
macrophages and NK cells
Question 91
Answer
-
humoral immunity
-
non-specific defence
-
cell mediated immunity
-
none of these
Question 92
Question
The ratio of T cells to B cells is
Question 93
Question
T cells and B cells are originated in
Answer
-
spleen
-
thymus
-
bone marrow
-
lymph nodes
Question 94
Question
Injection of anti-venom against snake bite is an example of
Answer
-
active immunity
-
passive immunity
-
non-specific immunity
-
phagocytic immunity
Question 95
Question
Which of the following statements are true regarding adaptive immunity?
Answer
-
prior exposure to antigen is essential
-
prior exposure to antigen is not essential
-
it is a non-specific defence mechanism
-
macrophages are the major cells involved
Question 96
Question
Active immunity involves
Question 97
Question
Active immunity is produced by
Answer
-
clonal selection
-
clonal expansion
-
both a and b
-
all of these
Question 98
Question
Cells involved in adaptive immunity or acquired immunity or specific defense include
Answer
-
T cells
-
B cells
-
Antigen presenting cells
-
All of these
Question 99
Question
Plasma cells are secreted by
Answer
-
T cells
-
B cells
-
Antigen presenting cells
-
Macrophages
Question 100
Question
The characteristics of passive immunity include
Question 101
Question
Immunologic memory is provided by
Answer
-
B cells
-
T cells
-
Both a and b
-
Phagocytes
Question 102
Question
A method for cell sorting based on the surface antigens (markers) which react specifically with fluorescent-labelled antibodies is called
Question 103
Question
A technique in which tissues and cells are examined by a fluorescent light microscope using fluorescent-labeled antibodies is called
Question 104
Question
A technique for the identification of proteins in serum or other fluid by electrophoresis and subsequent immunodiffusion is called
Question 105
Question
Classical pathway of complement system is activated by
Question 106
Question
Alternate pathway of complement system is activated by
Question 107
Question
Classical pathway of complement system is involved in
Answer
-
specific defence
-
adaptive immunity
-
both a and b
-
non-specific defence
Question 108
Question
Alternate pathway of complement system is involved in
Answer
-
non-specific defence
-
innate immunity
-
both a and b
-
adaptive immunity
Question 109
Question
Complement system
Question 110
Question
Complement system is involved in
Answer
-
specific defence
-
non-specific defence
-
both a and b
-
none of these
Question 111
Question
Kupffer cells are macrophages found on
Question 112
Question
Antiviral glycoproteins released by living cells in response to viral attack and induce a viral resistant state to neighboring cells is called as
Answer
-
natural killer cells
-
complement system
-
phagocytes
-
interferons
Question 113
Question
Newborns get their antibodies from mothers milk. This is an example of
Answer
-
Naturally acquired active immunity
-
Artificially acquired active immunity
-
Naturally acquired passive immunity
-
Artificially acquired passive immunity
Question 114
Question
Which of the following is the site of T cell maturation?
Answer
-
Bone marrow
-
Thymus
-
Spleen
-
Appendix
Question 115
Question
Primary lymphoid organs include
Answer
-
Thymus and spleen
-
Thymus and bone marrow
-
Thymus, bone marrow and spleen
-
Thymus, bone marrow, spleen and lymph nodes
Question 116
Question
The major chemical messenger involved in hypersensitivity is
Answer
-
interferons
-
histamines
-
lymphokines
-
interleukines
Question 117
Answer
-
macrophages
-
B cells
-
T cytotoxic cells
-
T helper cells
Question 118
Question
Regarding the inflammatory response:
Answer
-
Tissue swelling is the first stage of the inflammatory response.
-
Mast cells secrete chemotactic agents that attract lymphocytes
-
Macrophages secrete vasoactive materials during the inflammatory response
-
The inflammatory response can be triggered by antibody binding to the surface of micro-organisms.
Question 119
Question
Natural killer cells only destroy cells infected with a virus.
Question 120
Question
The antigens below are on your erythrocytes (red blood cells) which antibodies would you expect to find in the serum
1/ A- [blank_start]B[blank_end]
2/ B- [blank_start]A[blank_end]
3/ O- [blank_start]AB[blank_end]
Answer
-
B
-
A
-
AB
-
O
-
A
-
B
-
AB
-
O
-
AB
-
O
-
A
-
B
Question 121
Question
Fill in the Blanks (No - symbol needed)
1/ Precursor Chain + [blank_start]L fucose[blank_end]= H-Antigen
2/ H-Antigen + [blank_start]N acetylgalactosamine[blank_end]= A-Antigen
3/ H-Antigen + [blank_start]D Galactose[blank_end]= B-Antigen
Answer
-
L fucose
-
N acetylgalactosamine
-
D Galactose