MCB 2050 The Nucleus

Which cell cycle phase are most cells in our body in?

During which mitotic phase does the breakdown of the nuclear envelope occur?

Cyclins and CDKs control progression through the cell cycle checkpoints by inhibiting transitions from one phase to the next (negative control).

At G2/M checkpoint, Cdks target nuclear proteins: - Phosphorylation of [blank_start]histones and condensins[blank_end] leads to chromatin condensation. - Phosphorylation of [blank_start]lamins[blank_end] leads to the disassembly of the nuclear lamina. - Phosphorylation of [blank_start]nups[blank_end] leads to the disassembly of the NPC.

Exportin moves back to the nucleus via the [Ran GDP] gradient.

In the [blank_start]nucleus[blank_end], [blank_start]RCC1[blank_end] converts RanGDP to RanGTP.