Psychiatry Genetics

By what mechanism is Huntington’s Disease inherited?

If your patient has an autosomal dominant condition, what are the chances that their child will get it?

In genetics, what name is given to the phenomenon whereby as a genetic disorder is passed on from generation to generation, the symptoms of the disorder become apparent at an earlier age with each generation?

Huntington's Disease patients tend to experience which of the following symptoms?

Huntington's disease is caused genetically via repeats of a series of bases - [blank_start]CAG[blank_end]

The CAG repeats in Huntington's disease occur on the [blank_start]1st[blank_end] exon encoding the poly-[blank_start]glutamine[blank_end] protein

When an individual has more than [blank_start]38[blank_end] CAG repeats on the 1st exon encoding glutamine, they will develop Huntington's at some point in their life.

A normal human has less than [blank_start]32[blank_end] CAG repeats on the 1st exon encoding poly-glutamine

The more CAG repeats that are present, the earlier in life the individual will develop Huntington's Disease

Which of these symptoms would be inconsistent with mania with psychotic symptoms?

Bipolar I is a condition that affects roughly 1% of the British population. Is Bipolar I associated with mania or hypomania?