Quiz
Hypersensitivity reactions
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Questions in this quiz (28)
1All of the following are correctly matched except?
- AType I HSR - IgE mediated
- BType II HSR - IgA mediated
- CType III HSR - Immune complex - IgG mediated
- DType IV HSR - Cell mediated
2All of the following are true about hygiene hypothesis except
- AExcessive hygeine
- BOveruse of antibiotics
- CNot vaccinating the child
3All of the following are components of a typical adaptive response to an helminthic infection except
- ACDH4 Th1 cells
- BCytokines - IL 3,4,5,9,10,13
- Cantibodies IgE and IgG 1 and 4
- DEffector cells such as eosinophils, basophils and mast cells
4The main components of type I HSR are neutrophils and lymphocytes
- ATrue
- BFalse
5Sensitization to antigen involves class switching to IgE production on first contact with an allergen
- ATrue
- BFalse
6All of the following are stages in HSR I except
- AInitial exposure to immunogen which results in the production of reactive B and T cells - no symptoms
- BB cell - T cell interaction - antigen activation of Th2 cells
- CProduction of IL 4 + IL 13
- DProduction of IgE
- EBinding of IgE to Fc Epsilon Receptor and activation/sensitization of mast cell and release of mediators
- FNone of the above
7The following is true about HSR I immediate and late response
- AWithin minutes mast cell + Basophils will release histamine and serotonin causing wheal and flare
- BIn hours Eosinophils +Th2 will release second wave of mediators prostaglandis and leukotrienes
- CBoth are correct
- DNone of the above
8Intrinsic asthma is Type I HSR reaction
- ATrue
- BFalse
9The Primary method for diagnosing HSR I is by skin testing, with the characteristic response being "wheal and flare" reaction within minutes
- ATrue
- BFalse
10RAST detects IgG anti-allergen in patient's serum
- ATrue
- BFalse
11All of the following are used as treatment strategies for HSR I
- AAllergen avoidance
- BCorrect Th1/Th2 imbalance (not clinically feasible)
- CBlock mediators either with antihistamine, lipoxygenase inhibition or steroid use
- DCorrect isotype switch to IgE
- EPrevent IgE binding to mast cells to prevent IgE mediated degranulation
12Epinephrine is the main treatment for anaphylaxis - true or false
- ATrue
- BFalse
13In desensitization treatment the allergen binds to IgG thereby preventing IgE mediated response - true or false
- ATrue
- BFalse
14Omalizumab is a mab that binds to Fc region of IgE thereby blocking the arming of mast cells - true or false
- ATrue
- BFalse
15All of the following are true about HSR II except
- AHSR II is mediated by IgG or IgM not IgE
- BHSR II the antibodies bind to the self antigen on cell membranes and extracellular matrix
- CHSR II makes autoreactive antibodies
- DHSR II activates the alternate complement pathway
16All of the following are mechanisms for cell damage in HSR II except?
- Arecruitment of neutrophils - causing tissue injury and inflammation
- BOpsonization and Phagocytosis
- CInterfere with cellular functions - either block or stimulate cell receptors
- DAll of the above
- ENone of the above
17All of the following are HSR II reactions except
- AHemolytic disease of the newborn
- BBlood transfusion reactions
- CPenicillin reaction
- DExtrinsic asthma
18All of the following are true regarding Hemolytic disease of the newborn (HDNB) except
- ASeen when mother is Rh+ and baby is Rh-
- BMother is O type blood group and baby A,B or AB
- CPrevention is by giving Rhogam to the mother
- DNone of the above
19All of the following are non cytotoxic type II HSR diseases except
- AMyasthenia gravis
- BNDIIM
- CGraves disease
- DPernicious anemia
- EPenicillin allergy
20All of the following are cytotoxic HSR II except?
- AErythroblastosis fetalis (Hemolytic disease of the newborn)
- BPCN reaction
- CRheumatic fever
- DAutoimmune thrombocytopenic purpura
- EGoodpasture syndrome
- FGrave's disease
21Type III HSR - damaged tissues are innocent bystanders when a circulating (soluble antigen) immune complex becomes deposited in the tissues - true or false
- ATrue
- BFalse
22When immune complexes (ICs) exceed disposal the net result is inflammation locally or systemically - true or false
- ATrue
- BFalse
23All of the following are Type III HSR except
- ASerum sickness
- BFarmer's lung (Arthus reaction)
- CSLE
- DPost Streptococcal glomerulonephritis (PSGN)
- ENone of the above
24Lumpy bumpy pattern of nephritis is characteristic of PSGN - true or false
- ATrue
- BFalse
25All of the following are true about Arthus reaction except?
- AFarmer's lung is an example of Arthus reaction
- BArthus reaction is used in the skin testing of HSR III
- CArthus reactions are visualized in the skin
- Dnone of the above
26All of the following are true about delayed type IV HSR except?
- AStarts 49-72 hours after antigen exposure
- BT cell release cytokines that activate macrophages resulting in cell damage
- CB cells form antibodies that are delayed in their response hence called delayed HSR
- DMediated by Th1 cells and CD8+ cytotoxic T cells
27HSR IV is an inappropriate manifestation of DTH response that normally protects against intracellular bacterial and fungal infections - true or false
- ATrue
- BFalse
28All of the following are examples of IV HSR except
- APPD
- BPoison ivy dermatitis
- Ccontact dermatitis due to nickel exposure
- DCeliac disease
- EPSGN
Information
- Description
- All four hypersensitivity reactions
- Author
- ivenkat
- Language
- English
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- 1,803
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