Question 1
Question
Permanent tissues (cardiac muscle, skeletal muscle and nerves) cannot undergo hyperplasia, as they do not have stem cells
Question 2
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Metaplasia is an adaptive change from one ___________________________ cell type to ________________________________-
Question 3
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Dysplasia is recognized by the alteration in the ___________________________ of cells and is still ______________________
Question 4
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All of the following are key drivers of cell injury except?
Answer
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Loss of ATP
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Increase in cytoplasmic calcium
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decrease in cytoplasmic calcium
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Generation of Reactive oxygen species
Question 5
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All of the following are conditions where there is hypoxia without ischemia
Question 6
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Loss of ATP in cell injury leads to all of the following except
Answer
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Impairs oxidative phosphorylation
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Loss of function of Na/K ATPase pump
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Calcium influx thereby increasing intracytoplasmic calcium
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Increase in pH causing clumping of chromatin
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decreased protein synthesis due to ribosomal dysfunction and swelling
Question 7
Question
All of the following result due to increased cytoplasmic calcium in cell injury except?
Answer
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Increased calcium activates phospholipase, protease, endonuclease and ATPase etc
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It also activates mitochondrial permeability transition pore which results in loss of membrane potential of mitochondria further limiting oxidative phosphorylation
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Lipid peroxidation and membrane damage
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None of the above
Question 8
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All of the following about ROS is correct except
Question 9
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Which of the following are the morphological changes that are seen in REVERSIBLE cell injury?
Question 10
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The morphologic hallmark of cell death (irreversible cell injury) is loss of nucleus
Question 11
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Coagulative necrosis in which tissue becomes a dry, opaque, eosinophilic mass containing the outlines of anucleated cells, resulting from the denaturation of proteins following hypoxia - is seen in all tissues except brain
Question 12
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Pancreatitis exhibits 2 forms of necrosis they are 1____________________ and 2____________________________
Question 13
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Caseous necrosis usually caused by mycobacterial or fungal infections
Question 14
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The difference between dry and wet gangrene is that dry gangrene is associated with infection whereas the wet gangrene is not
Question 15
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Resumption of blood supply and oxygenation to ischemic tissue may lead to further injury and tissue destruction
Question 16
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Necrosis happens to a group of cells which leads to inflammation whereas apoptosis affects single cells marked by shrinkage of the cell, condensation of chromatin, formation of cytoplasmic blebs and fragmentation of the cell into membrane bound apoptotic bodies that are eliminated by phagocytosis
Question 17
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Regarding apoptosis
Answer
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Anti apoptotic proteins are BCL-2,BCL-XR, MCL1 - keep the Mitochondrial outer membrane impermeable by preventing the leakage of cytochrome c and other death-inducing proteins into the cytosol
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Pro-apoptotic BAX and BAK upon activation oligomerizes within the outer mitochondrial protein and promote mitochondrial permeability by forming a channel in the outer membrane that allows leakage of cytochrome c from the intermembranous space
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apoptosis is mediated by caspases - intrinsicpathway by inactivation of BCL-2
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Extrinsic pathway via FasL-Fas death receptors
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All of the above are true
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1,2 and 4 are true
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3,4 are true
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None of the above
Question 18
Question
Atrophy is a result of decrease in stress which results in decrease in size and or volume of cell mass