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Viral Genome and RNA's

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Year 2 Quiz on Viral Genome and RNA's, created by gina_evans0312 on 28/12/2013.
gina_evans0312
Quiz by gina_evans0312, updated more than 1 year ago
gina_evans0312
Created by gina_evans0312 almost 11 years ago
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Resource summary

Question 1

Question
How does a retroviruse reproduce?
Answer
  • Nuclear fission
  • Reverse transcription onto host genome
  • Binary fission

Question 2

Question
Reverse Transcriptase is vital for RNA retroviruses to replicate
Answer
  • True
  • False

Question 3

Question
The viral protein P is used for what?
Answer
  • Packaging signal for making virus particles
  • Capsid protein
  • For genome expression

Question 4

Question
Gag is the gene for envelope proteins
Answer
  • True
  • False

Question 5

Question
Which of the following can be directly translated?
Answer
  • +ve sense RNA
  • -ve sense RNA

Question 6

Question
What protein converts viral genomes into a version host cells can transcribe?
Answer
  • RNA dependent RNA polymerase
  • DNA dependent RNA polymerase
  • DNA dependent DNA polymerase
  • RNA dependent DNA polymerase

Question 7

Question
The Transcriptosome is the cell repetoire of proteins
Answer
  • True
  • False

Question 8

Question
What is the role of enhancers?
Answer
  • To make proteins more efficient
  • To make transcription of a gene more likely
  • To increase cell division

Question 9

Question
Name the types of enhances possible
Answer
  • Upstream
  • Adjactent
  • Downstream
  • Internal

Question 10

Question
Introns can make up to 2% of the gene
Answer
  • True
  • False

Question 11

Question
Assuming the middle segment is an intron, what is found at the 5' and 3' splice sites of the intron?
Image:
Splicing (image/png)
Answer
  • 3'- G-T 5'- Pyrimidine tract
  • 5' - G-U 3' - Pyrimidine tract & A-G
  • 5' - Pyrimidine tract & A-T 3' G-A

Question 12

Question
How is the 5' intron splice site cleaved?
Answer
  • Hydroxyl attack by an adenine
  • Hydroxyl attack by a pyrimidine from the 5' exon splice site
  • The 5' exon splice site attacks the 3' intron splice site

Question 13

Question
The 5' is cleaved and the intron loops on itself- what removes the intron totally?
Answer
  • The 5' exon attacks the 3' splice site
  • The 3' exon attacks the 5' splice site
  • The 3' exon attacks itself

Question 14

Question
What is the roles of snRNA?
Answer
  • Help for splicosome
  • Resist formation of the splicosome
  • Remove intron after splicing

Question 15

Question
Twintrons are introns within introns
Answer
  • True
  • False

Question 16

Question
Which is spliced out first?
Answer
  • Introns
  • Twintrons

Question 17

Question
GpG islands are found near transcriptionally inactive human genes
Answer
  • True
  • False

Question 18

Question
Name the two theories concerning introns
Answer
  • Introns are ancient and are gradually being lost
  • Introns are new and are gradually being accumulated

Question 19

Question
What does snoRNA stand for?
Answer
  • Small nuclear RNA
  • Small nullifying RNA
  • Small nucleolear RNA

Question 20

Question
snoRNA causes RNA to be acetylated
Answer
  • True
  • False

Question 21

Question
SnoRNA binds to the RNA to be modified
Answer
  • True
  • False

Question 22

Question
What can SnoRNA binding lead to?
Answer
  • The modification of bases
  • The destruction of the mRNA
  • The replication of the mRNA

Question 23

Question
There are few miRNA's, but they are very large
Answer
  • True
  • False

Question 24

Question
What is the role of miRNA
Answer
  • mRNA silencing
  • Prevent mRNA degredation
  • Inhibit transcription

Question 25

Question
Once the miRNA is transcribed, what structures form?
Answer
  • Cruciforms
  • Holliday junctions
  • Stem-loop junctions

Question 26

Question
What enzyme have these miRNA precursors NOT been cut by?
Image:
miRNA_Precursors (image/png)
Answer
  • Drosher
  • Dicer

Question 27

Question
Once complete, where do these miRNA structures do?
Image:
miRNA (image/png)
Answer
  • Binds to 5' end of mRNA to prevent ribosome binding
  • Bind to region between polyA tail and gene, causing cleavage of polyA tail
  • Bind in centre and cause mRNA looping

Question 28

Question
siRNA stands for Short Interfering RNA
Answer
  • True
  • False

Question 29

Question
What is the main role of siRNA?
Answer
  • Protection against RNA viruses
  • Protection against oncogenes
  • Protection against bacteria

Question 30

Question
Where and to what does siRNA bind?
Answer
  • mRNA of viral genome
  • mRNA of bacterial genome
  • mRNA of human genome
  • On transcribing region
  • On poly-A tail

Question 31

Question
siRNA binds to mRNA in a double stranded form
Answer
  • True
  • False

Question 32

Question
Which of the following could be used as a gene therapy?
Answer
  • miRNA
  • siRNA
  • snRNA
  • snoRNA

Question 33

Question
This RNA gene therapy works by making a dsRNA version of a gene in the cell; this will be cleaved to siRNA which will destroy ALL mRNA for that gene
Answer
  • True
  • False
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