630602
Description
Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
over 10 years ago
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Question 1
Question
B Cells recognise native antigens, T cells recognise processed antigens
Answer
- True
- False
Question 2
Question
Which of the following are NOT professional antigen presenting cells?
Answer
-
Neutrophils
-
Macrophages
-
Dendritic cells
Question 3
Question
CD8 T-cells recognise which MHC complex?
Answer
-
MHCI
-
MHCII
Question 4
Question
CD4 is for the detection of virally infected cells
Answer
- True
- False
Question 5
Question
CD4 cells recognise MHCII, which uses which Antigen processing system?
Answer
-
Endosomal
-
Endogenous
-
Endomal
Question 6
Question
Cells with MHCI present using the endogenous AP system
Answer
- True
- False
Question 7
Question
T- cells cannot recognise soluble, native antigens
Answer
- True
- False
Question 8
Question
Put the following steps in the correct order- A (Antigen-MHC Complex Formation), B (Uptake), C (Presentation) and D (Degredation
Answer
-
B-D-A-C
-
A-B-D-C
-
A-C-B-D
Question 9
Question
Which of the following definitions is incorrect?
Answer
-
Uptake- picking up of the antigen from surrounding fluid
-
Degredation- total digestion of the antigen
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Presentation- movement of the complex to the cell surface
Question 10
Question
Endosomal Pathway- What is it for?
Answer
-
Processing of extracellular antigens picked up by antigen presenting cells
-
Processing of cytosolic viral antigens
Question 11
Question
Endosomal Pathway- Uses the MHCI complex
Answer
- True
- False
Question 12
Question
Endosomal Pathway- The extracellular antigen is picked up by phagocytosis
Answer
- True
- False
Question 13
Question
Endosomal Pathway- How is picking up of the antigen mediated?
Answer
-
Receptor mediated
-
Compliment mediated
-
Hormone mediated
Question 14
Question
Endosomal Pathway- The antigen containing endosome only binds to the MCHII containing endosome after partial digestion
Answer
- True
- False
Question 15
Question
Endosomal Pathway- How is the active site of MHCII covered in the cell?
Answer
-
Covered by an invariant 'cap'
-
The two parts are connect by a subunit that must be removed
-
Receptor surface is bound to the endosome envelope
Question 16
Question
Endosomal Pathway- The cover of the MHC complex is called a CLIP
Answer
- True
- False
Question 17
Question
Endosomal Pathway- How is the processed antigen added to the MHCII complex?
Answer
-
Acessory proteins swap the CLIP for the peptide when the two vesicles fuse
-
Acessory proteins remove the MHCII from the envelope when the two vesicles fuse
-
Acessory proteins remove the subunit connecting the two halves when the two vesicles fuse
Question 18
Question
Endogenous Pathway- Main use is for what?
Answer
-
Viral antigen processing
-
Professional pesentation of antigens
Question 19
Question
Endogenous Pathway uses MHCII
Answer
- True
- False
Question 20
Question
Endogenous Pathway- How are cytosolic antigens processed?
Answer
-
By the TCR
-
By MHCI
-
By cytosolic proteases
Question 21
Question
Endogenous Pathway- Digested peptides are moved into the Golgi by what?
Answer
-
Transporter Associated with Antigen Processing (TAP 1&2)
-
Transporter Associated with Antigen Digestion (TAD 1&2)
-
Transporter Associated with Antigen Presentation (TAP 1&2)
Question 22
Question
In the Golgi the processed peptide is bound to MHCI and they complex is loaded into a vesicle for transport to the cell membrane
Answer
- True
- False
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