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Jon dL
Quiz by Jon dL, updated more than 1 year ago
Jon dL
Created by Jon dL almost 8 years ago
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Question 1

Question
The field of immunology expanded along with the development of vaccines. The first widely used vaccine was against the human disease smallpox and was developed from the
Answer
  • vaccinia virus
  • variola virus
  • monkeypox virus
  • chickenpox virus

Question 2

Question
The person who coined the term ‘chemotherapy’ and was the first to focus research efforts on the development of drugs to treat infectious disease was
Answer
  • Edward Jenner
  • Louis Pasteur
  • Paul Ehrlich
  • Alexander Fleming

Question 3

Question
A “magic bullet” drug to stop HIV replication might be
Answer
  • inhibition of nucleic synthesis by Rifamycin
  • inhibition of reverse transcriptase by Lamivudine
  • inhibition of protein synthesis by Streptomycin
  • inhibition of microtubule function by Mebendazole

Question 4

Question
What type of dendritic cell releases CCL 19 and 21 attracting B cells to the lymph nodes?
Answer
  • Dendrite
  • APC Dendritic
  • Follicular Dendritic

Question 5

Question
Which complement pathway(s) result in complement fixation?
Answer
  • Alternative
  • Lectin
  • Classical
  • All (alternative, lectin, classical)

Question 6

Question
A cell that has a differentiated Heavy (mew) chain and has not yet undergone light chain rearrangement is known as?
Answer
  • Pro-B cell
  • Pre-B cell
  • Mature B cell
  • Immature B cell

Question 7

Question
Neutrophils secrete many cytokines.
Answer
  • True
  • False

Question 8

Question
Innate immunity is required for adaptive immunity to occur.
Answer
  • True
  • False

Question 9

Question
Which of the following is not a granulocyte?
Answer
  • Eosinophil
  • Basophil
  • Monocyte
  • Neutrophil

Question 10

Question
A ‘magic bullet’ drug to control an infection with Candida albicans (thrush) or Tinea pedis (athlete’s foot) might target which of the following?
Answer
  • Ergosterol
  • 70S ribosomes
  • Peptidoglycan

Question 11

Question
Your 1st defense against infection is
Answer
  • Macrophages
  • Neutrophils
  • Skin and mucosal membranes
  • Lymphocytes

Question 12

Question
Which of the following is NOT a phagocyte?
Answer
  • Macrophage
  • Neutrophil
  • Dendritic cell
  • Natural Killer cell

Question 13

Question
I am a cell that plays an important role: -in innate immunity -as an antigen presenting cell -in the initiation of adaptive immunity I am a:
Answer
  • Basophil
  • Neutrophil
  • Dendritic cell
  • Natural Killer cell

Question 14

Question
An example of a primary lymphoid organ is:
Answer
  • Spleen
  • Appendix
  • Thymus
  • Peyer’s patch

Question 15

Question
The success of vaccination relies on development of a good memory response. Immunological memory develops during the __________ immune response and results in higher antibody titers in the __________ response:
Answer
  • Innate, primary
  • Innate, secondary
  • Adaptive, primary
  • Adaptive, secondary

Question 16

Question
What is an immediate (first) complement response of our innate immune system to bacterial infection?
Answer
  • Classical pathway
  • Lectin pathway
  • Alternative pathway
  • Garden pathway

Question 17

Question
Which complement pathway is activated by antibody?
Answer
  • Classical
  • Alternative
  • Lectin
  • All of the above

Question 18

Question
Complement activation results in:
Answer
  • Increased opsonization
  • Increased inflammatory response
  • Formation of a membrane attack complex
  • All of the above

Question 19

Question
Cells which are most important in immune surveillance for tumor cells are:
Answer
  • TH1 and TH2 cells
  • TH2 and B cells
  • TH1 and B cells
  • NK and CD8 T cells

Question 20

Question
A tumor occurring in a lymph node would be called:
Answer
  • Leukemia
  • Sarcoma
  • Lymphoma
  • Carcinoma

Question 21

Question
The Ames test allows detection of:
Answer
  • Carcinogens
  • Mutagens
  • Tumors
  • Proto-oncogenes

Question 22

Question
If an autoantibody is made against a cell-surface antigen, the autoimmune disease is considered a:
Answer
  • Type I
  • Type II
  • Type III
  • Type IV

Question 23

Question
Autoimmune diseases can be described as:
Answer
  • Over-reaction of the human systems to harmless environmental antigens.
  • Under reaction of the immune system to harmless environmental antigens.
  • Gain of tolerance to self-antigens.
  • Loss of tolerance to self-antigens.

Question 24

Question
An example of a minor histocompatibility complex antigen is:
Answer
  • XSCID
  • H-Y
  • HVGD
  • H-DR

Question 25

Question
If one wants to minimize the chance of GVHD following a hematopoietic cell transplants, one could administer the cytotoxic drug:
Answer
  • Rapamycin
  • Tacrolimus
  • Methotrexate
  • Prednisone

Question 26

Question
The main tissues affected by GVHD are:
Answer
  • Skin, liver and GI tract
  • Kidney, liver and heart
  • Skin, kidney and liver
  • Hair, kidney and skin

Question 27

Question
_____ transplants do not require extensive HLA matching, but _____ transplants do.
Answer
  • Cornea, liver
  • Heart, cornea
  • Liver, bone marrow
  • Bone marrow, cornea

Question 28

Question
A drug that inhibits IL-2 production is:
Answer
  • Azathioprine
  • Tacrolimus
  • Methotrexate
  • Prednisone

Question 29

Question
In dengue infection cross-reactive memory T cells recovered exhibited a higher affinity to variant epitopes representing serotypes of previous exposure – a phenomenon called:
Answer
  • Antibody-dependent enhancement
  • ADCC
  • Original antigenic sin
  • Immune complexes

Question 30

Question
Inflammatory cytokine _____ levels have been shown to be higher in DHF than in DF suggesting a role in vascular plasma leakage.
Answer
  • IFN-gamma, IL-2
  • TNF-alpha, IL-1
  • IL-10, IL-2
  • IL-6, IL-4

Question 31

Question
The genome of dengue virus is _____ and contains _____ genes.
Answer
  • 11 kb; 10
  • 15 kb; 20
  • 20 kb; 30
  • 25 kb; 40

Question 32

Question
Currently DHF and DSS represent _____ of total hospitalized dengue cases.
Answer
  • 1-25%
  • 10-50%
  • 2.5-40%
  • 5-220%

Question 33

Question
Dengue virus is a:
Answer
  • Filovirus
  • Flavivirus
  • Herpes virus
  • Rhinovirus

Question 34

Question
Anaphylatoxins produced by activated complement include:
Answer
  • C4b and C2a
  • C3b and C4a
  • C3a and C5a
  • C2b and C3a

Question 35

Question
Therapeutic monoclonal antibodies can affect the target cell by:
Answer
  • Inhibition of calcineurin and induction of apoptosis
  • Inhibit JAK 3 and induction of apoptosis
  • Block or down regulate surface molecules and induction of apoptosis
  • Disrupt DNA replication

Question 36

Question
When a graft is considered to have stable function, treatment is modified from:
Answer
  • Xenobiotics to biological
  • Biologicals to maintenance
  • Induction to maintenance
  • Xenobiotics to induction

Question 37

Question
Based on data presented by Andrew Read, the regimen for malaria treatment determined by the WHO actually:
Answer
  • Decreases competition by sensitive organisms allowing an increase in resistant organisms in an individual
  • Increase the number of resistant transmission-state organisms
  • Increases transmission of resistant organisms
  • All of the above
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