Zusammenfassung der Ressource
ROGER’s Painful Toe
- Biochemistry of
purine metabolism
- DDx of Big Toe Pain
- Trauma
- Arthritis
- Hallux Valgus (Bunion)
- Hallux rigidus
- Sesamoiditis
- Gout
- Primary gout (90%)
- Overproducation of uric acid
- Decreased excretion of uric acid
- Alcohol consumption
- Renal failure
- Diet (seafood, red meat)
- Fructose containing cyrup
- Chemotherapy, radiotherapy
- Secondary gout (10%)
- Increased cell turnover
- Inborn errors of metabolism
- Pathogenesis
- Risk factors
- Age
- Genetics
- Obesity
- Medications
- Thiazides
- Low-dose aspirin
- Signs and symptoms
- Podagra
- Tophi
- Swollen inflamed joint
- Complications
- Joint deformity
- Osteoarthritis
- Renal stones
- Sinus may
be infected
- Pseudogout
- Deposition of Calcium
Pyrophosphate crystals
- Causes
- Hyperparathyroidism
- Hemochromatosis
- Etidronate disodium therapy
- Angiography
- Investigations
- X-ray
- CBC
- Joint aspiration
- Biochemical tests
- Uric acid levels
- BUN levels
- Management
- Acute
gouty
arthritis
- NSAIDs
- Corticosteroids
- Colchicine
- Hyperuricemia
- Xanthine oxidase inhibitors
- Uricoseric drugs
- Probenecid
- Pegloticase
- Allopurinol
- Prognoisis
- Treatable with
good prognosis
if treated
directly