Platelet and coagulation disorders

Beschreibung

Mindmap am Platelet and coagulation disorders, erstellt von Pooja Acharya am 09/03/2020.
Pooja Acharya
Mindmap von Pooja Acharya, aktualisiert more than 1 year ago
Pooja Acharya
Erstellt von Pooja Acharya vor mehr als 4 Jahre
511
0

Zusammenfassung der Ressource

Platelet and coagulation disorders
  1. Hemostasis
    1. Sequence of events
      1. Fibrinolysis
        1. TPA
          1. Plasmin
            1. Fibrin
              1. FDP
                1. D-dimer
                  1. Marker of PE
          2. Vasoconstriction
            1. Neurohumoral
              1. Endothelin
              2. Primary plug
                1. Platelet adhesion
                  1. VWF binds to GIb on platelets
                    1. VWF glues subendothelial collagen
                      1. Platelet shape change
                      2. Platelet activation
                        1. Release of platelet contents
                          1. Flip in the phospolipid membrane
                            1. ADP activates the GIIb receptor
                            2. Platelet aggregation
                              1. Binding GIIb betn platelets with fibrinogen
                            3. Secondary hemostatic plug
                              1. Coagulation cascade on platelet membrane
                                1. Instrinsic pathway
                                  1. Surface activation FXII
                                    1. PTT
                                      1. 50: 5O Correction
                                        1. FVII, IX, XI, XII
                                        2. 50:50 correction
                                          1. Circulating antibodies
                                            1. SLE, APLA
                                      2. Extrinsic pathway
                                        1. PT
                                          1. 50:50 correction
                                            1. FVII
                                            2. 50:50 no correction
                                              1. Antibodies
                                          2. Common pathway
                                            1. X-->Xa
                                              1. Proth--> Thrombin
                                                1. Fibrinogen--> Fibrin
                                          3. Clot stabilization
                                            1. FXIII
                                      3. Thrombophilia
                                        1. Virchows triad
                                          1. Hypercoagulability
                                            1. Factor V L mutation
                                              1. Va is resistant for inactivation by APC
                                              2. AT-III Def
                                                1. Thrombin uninhibited
                                                2. PT gene mutation
                                                  1. Increased Prothrombin
                                                  2. HIT
                                                    1. Unfractioned heparin
                                                      1. Thrombocytopenia
                                                        1. Antibodies to PF-2
                                                        2. APLA
                                                          1. Antibodies to Glycoprotein I
                                                            1. False + VDRL
                                                              1. Rec PE
                                                                1. Repeated abortions
                                                                  1. Libmann sack endocarditis
                                                                2. Stasis
                                                                  1. Prolonged immobilization
                                                                  2. Endothelial dysfunction
                                                                    1. Smoking
                                                                      1. Atherosclerosis
                                                                  3. Thrombocytopenia
                                                                    1. Decreased production
                                                                      1. Marrow failure
                                                                        1. Leukemia or infiltration
                                                                        2. Decreased survival
                                                                          1. Acute ITP
                                                                            1. Child after viral
                                                                              1. <20000 results in ICH
                                                                            2. Chronic ITP
                                                                              1. Antibodies to GPIb or GPIIb
                                                                                1. Seen in females,
                                                                                  1. Diagnosis by exclusion
                                                                              2. Quantitative disorder
                                                                                1. Qualitative disorders
                                                                                  1. Bernard soulier
                                                                                    1. Adhesion defect absent GPib
                                                                                      1. RIPA reduced
                                                                                        1. Platelet count normal
                                                                                        2. Glanzmann
                                                                                          1. Platelet aggregation defect
                                                                                            1. Defective GPIIb/IIIa
                                                                                              1. Ristocetin -normal
                                                                                            2. VWD
                                                                                              1. VWF secreted from Endothelial cell
                                                                                                1. Adhesion defect
                                                                                                  1. RIPA reduced
                                                                                                    1. Desmopression increases release of VWF
                                                                                                    2. MAHA
                                                                                                      1. TTP
                                                                                                        1. Neurological
                                                                                                          1. Thrombocytopenia
                                                                                                            1. Renal failure
                                                                                                              1. Fever
                                                                                                                1. Hemolytic anemia
                                                                                                                  1. Defect in ADMATS-13
                                                                                                                  2. HUS
                                                                                                                    1. Endothelial dysfunction due to toxin
                                                                                                                      1. After eating hamburger
                                                                                                                        1. Renal failure
                                                                                                                          1. No neurological manifestation
                                                                                                                            1. ECOLI O157:H7
                                                                                                                            2. DIC
                                                                                                                              1. Bleeding from iv canula
                                                                                                                                1. Extensive endothelial injury
                                                                                                                                  1. TF release
                                                                                                                                  2. etiology
                                                                                                                                    1. Obstretic complications
                                                                                                                                      1. Sepsis
                                                                                                                                        1. severe burns
                                                                                                                                        2. Lab diagnosis
                                                                                                                                          1. Increased PT, PTT INR
                                                                                                                                            1. Low platelets
                                                                                                                                              1. Reduced fibrinogen
                                                                                                                                          2. Coagulation factor defects
                                                                                                                                            1. Hemophilia A
                                                                                                                                              1. Raised PTT
                                                                                                                                                1. 50:50 Mix correction
                                                                                                                                                  1. FVIII DEF
                                                                                                                                                    1. X- Recessive
                                                                                                                                                    2. Hmeophilia B
                                                                                                                                                      1. FIX Deficiency
                                                                                                                                                        1. XR
                                                                                                                                                      Zusammenfassung anzeigen Zusammenfassung ausblenden

                                                                                                                                                      ähnlicher Inhalt

                                                                                                                                                      Einstufungstest Italienisch Niveau A1.2
                                                                                                                                                      SprachschuleAktiv
                                                                                                                                                      Juraexamen Karteikarten - Strafrecht
                                                                                                                                                      anna.grillborzer0656
                                                                                                                                                      M1, Kurs 2: Einführung in die Forschungsmethoden - Unit 1 - Psychologie als eine empirische Wissenschaft: Warum brauchen wir Forschungsmethoden?
                                                                                                                                                      Chris Tho
                                                                                                                                                      Qualitative und Quantitative Forschungsmethoden
                                                                                                                                                      Clarissa Müller-Stengel
                                                                                                                                                      BAS1 - Bau und Funktion des Bewegungsapparates (1)
                                                                                                                                                      susi.spakowski08
                                                                                                                                                      Sturm und Drang & Empfindsamkeit
                                                                                                                                                      Julia Schaffhirt
                                                                                                                                                      Wagenkunde
                                                                                                                                                      malimi something
                                                                                                                                                      Klinische Psychologie Teil 1
                                                                                                                                                      Lisa Mariá Hchil
                                                                                                                                                      Lernplan Analysis
                                                                                                                                                      Hanna Marie Hock
                                                                                                                                                      Meth: QUANTI
                                                                                                                                                      max knoll
                                                                                                                                                      Basiswissen_MS-4.2_Foliensatz I
                                                                                                                                                      Bernd Leisen