Hypersensitivity Reactions

Beschreibung

Tb is an intracellular
rpbardoul
Mindmap von rpbardoul, aktualisiert more than 1 year ago
rpbardoul
Erstellt von rpbardoul vor mehr als 9 Jahre
6
1

Zusammenfassung der Ressource

Hypersensitivity Reactions
  1. Type 1) Immediate
    1. Stage 1: Sensitization. Under normal curcumstances- IgM would be produced with APC production but release of IL4 (and some genetic predispositions) will promote an isotypic switch to IgE antibodies
      1. Stage 2: The activation stage: There is X reaction between the allergen and IgE which are located on MAST cells- degradation
        1. Stage 3: Effector stage: Degranualtion releases pharmocologically activ particles: chemokines, vasoactive and chemoactive molecules as well as enzymes which promote inflammation
      2. Atopc dermatits, milk allergy in Jersey cows, Mites and Penicillins
        1. Type 2
          1. This is when there are Ig's binding to normal cells and causing destruction via ADCC and complement cascades.
            1. IgG bind to ACH receptors of the oesophagus causing MegaE (Myasthenia Gravis
              1. IgG bind to platelets causing thrombocytopenia
                1. Maiden mares who are exposed (and develop Ig) to their foal (father inherited) antbodies during pregnancy. These Ig's are then passed into colustrum and cause neonatal jaundice
                2. Type 4) Delayed
                  1. **These DO NOT INVOLVE ANTIBODIES**- No B cells
                    1. This is when an antigen in inoculated into the skin and a SLOW (2-3d) inflammtory reponse is actvated
                      1. 1) The antigen migrates to local LN and APC'S are activated as the pathogen is processed and presented
                        1. 2) The T cells and NK cells travel to the inoculation site and induce inflammation
                          1. Allergic contact dermatitis occurs when certain chemicals/ toxins are absorbed into the skin
                            1. M. TB testing in cattle- a positive tuberculin test occurs if the animal has had prior exposure
                        2. Type 3
                          1. This is an immune COMPLEX mediated reaction where a large number of [Ig-Ab] activate the complement system
                            1. In normal circumstances these complexes are either phagocytosed or taken up by liver kuppfer cells for destruction. In these cases the antigen is chronic via... 1) Persistent infection, 2) An auto-immune issue or 3) An inhaled antigen
                              1. Rheumatoid arthritis
                                1. The ARTHUS response to vaccinations- this is a local issue which is common in cats
                                  1. Serum sickness: This is a sytemic response to passive immunization which may induce vascuitism edema and swelling of joints/ LN's
                                2. These have been characterised into 4 types- all activated by an ALLERGEN, those that become systemic are anaphylactic.. Pollen, fish, penicillin, Brazil nuts etc
                                  1. Benefits include the release of chitinases which degrade insects, fungi etc
                                  Zusammenfassung anzeigen Zusammenfassung ausblenden

                                  ähnlicher Inhalt

                                  Sehenswürdigkeiten Deutschlands
                                  Natalia Romanova
                                  Historische Fakten des 20. Jahrhunderts
                                  AntonS
                                  ABSOLUTISMUS - LUDWIG XIV
                                  Julian 1108
                                  BWL-Theorie (Allgemeines)
                                  Julian 1108
                                  Zeiten Englisch
                                  Janine Egli
                                  PR VO part2
                                  Anda Muresan
                                  Pädagogik Abitur 2016: Jean Piaget
                                  Lena S.
                                  Vetie - Tierzucht & Genetik - S VI
                                  Fioras Hu
                                  Vetie Allgemeine Pathologie Altfragen2016
                                  Nele Unger
                                  Vetie: Geflügelkrankheiten 2020
                                  Johanna Tr