Zusammenfassung der Ressource
Adaptive Immune Response
- It is specific
- Immune components are activated
only after infection start
- Response magnitude is higher in the
second and subsequent encounter
- Immunological memory is stored
- Lymphoid organs
- Primary
- Production sites
of immune cells
- Maturation sites for
immune cells in the
absence of antigen
- Secondary
- Maturation sites for
antigen-driven immune cells
- Lymphocyte
- T cells
- Mature in
thymus
- B cells
- Mature in bone
marrow
- Antigen- independence
- Have surface markers
or receptors
- Bind to antigens
- Bind to receptors
on other cells
- Transmit and
receive messages
- Receptor molecules
- Major histocompatibility
complex (MHS)
- Classes
- Class 1
- Expressed on all
nucleated cells
- Class 2
- Antigen-presenting
cells
- Class 3
- Protein associated with the
complement system
- Cluster of differentiation (CD)
- CD4
- Binds to MHS
class 2
- CD8
- Binds to MHS
class 1
- Antigen-specific
receptors
- Mature T and B cells
- Carry one specific type of
receptors called clones
- To eliminate lymphocytes that
recognize self-antigens
- T-cell receptors
- Supported by CD4 and CD8
- Immunoglobulins (Ig)
or antibodies in B cells
- IgG, IgA, IgM, IgE, IgD
- T-cell Response
- T helper cell
- Activate other
cells
- Memory
T cell
- Store immunological
memory
- Regulatory T cells
- Prevent excessive
inflammation and
autoimmunity
- Cytotoxic
T cells
- Attack infected,
cancerous and
foreign cells
- B cells
- Memory B cells
- Store immunological
memory
- Regulatory B cells
- Prevent excessive
inflammation and
autoimmunity
- Plasma cells
- Launch antibodies
- Neutralisation
- Opsonisation
- Agglutination
- Antitoxin action