550663
Beschreibung
Mindmap von Sophie Barrett, aktualisiert more than 1 year ago
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Erstellt von Sophie Barrett
vor fast 11 Jahre
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Enzyme-Linked Receptors
- Characteristics
- Often exist as inactive monomers
- Ligand binding
induces activation by
di/trimerisation
- the monomers
transphosphorylate
each other
- adaptor proteins recognise
change in structure
- Often exist as inactive monomers
- Transforming Growth Factor Beta (A Ligand)
- brings the monomers together (that exist seperatly)
- Heterodimerisation
occurs (the monomers are
not idetical)
- Phosphorylation occurs on the serine-threonine residues
- This ultimately activates the TGF receptor
- This ultimately activates the TGF receptor
- Phosphorylation occurs on the serine-threonine residues
- Heterodimerisation
occurs (the monomers are
not idetical)
- brings the monomers together (that exist seperatly)
- Nerve Growth Factor (NGF) (A Ligand)
- NGF presence causes
homodimerisation of receptors with
intrinsic cytosolic tyrosine kinase activity
- Phosphorylation occurs on the tyrosine residues
- note here, that the monomers are identical
- Phosphorylation occurs on the tyrosine residues
- NGF presence causes
homodimerisation of receptors with
intrinsic cytosolic tyrosine kinase activity
- Cytokines
- Heterodimerisation of receptors...
- whose cytosolic domains
are associated with
seperate non-tyrosine
kinases
- whose cytosolic domains
are associated with
seperate non-tyrosine
kinases
- Heterodimerisation of receptors...
- Receptor Tyrosine Kinase Signalling
- Trk Receptors = Tropomyosin-related Kinases
- The receptor for NGF is TrkA
- The receptor for BDNF
(brain-derived neurotrophic
factor) is TrkB
- The receptor for NT3
(Neurotrophin-3) is Trk C
- The receptor for NT4/5 is Trk B
- The receptor for NGF is TrkA
- Trk Receptors = Tropomyosin-related Kinases
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