Zusammenfassung der Ressource
WBC disorders
- leukopenias
- neutropenia
- increased destruction
- Immune destruction
- overwhelming infections.
- decreased production
- Aplastic anemia
- cancer chemotherapy
- lymphopenia
- HIV
- Corticosteroids
- Radiation
- Autoimmune diseases (SLE)
- Primary immune deficiency syndromes (SCID- Digeorge
- leukocytosis (proliferative disorders)
- reactive
- Neutrophilic leukocytosis
- Bacterial infections
- Eosiniophilia
- Type I hypersensitivity
- Lymphocytosis
- Viral infections
- Drugs (phynetoin)
- Monocytosis
- Chronic infections
- leukemoid reaction
- neoplastic
- Basophilia
- Chronic myeloproliferative disorders
- Lymphoid
Neoplasms
- Hodgkin lymphoma
- Non Hodgkin
lymphoma (NHL)
- Lymphocytic leukemia
- Plasma cell
neoplasms;
(multiple myeloma)
- Myeloid
neoplasms
- Acute myeloid
leukemia (AML)
- Chronic myeloproliferative
disorders (MPD):
- Chronic myeloid leukemia (CML)
- investigations
- FISH
- PCR
- karyotyping
- Bone marrow aspiration and biopsy
- Insidious onset
- Three stages
- Chronic Stage
- Accelerated Stage
- Blastic Stage
- Slow progression
- treatment options
- leads to
- Uncontrolled proliferation of
transformed cells
- Discordant maturation
- Escape from apoptosis
- Altered interaction with the cellular Matrix
- signs and symptoms
- spleenomegaly
- tyrosine kinase inhibitors
- interferon & radiation therapy
- chemotherapy
- bone marrow transplantation
- Polycythemia vera
- Myelofibrosis
- Essential thrombocythemia
- Myelodysplastic syndromes (MDS) (cytopenias )
- Histiocytic
neoplasms
- Langerhans cell histiocytosis
- history taking
- signs and symptoms