PHSI3012 01-1 Cell Proliferation

Beschreibung

Learning objectives: * Understand the difference between cell growth and proliferation * Describe the major events of the cell cycle * Appreciate the roles of cyclins and cyclin-dependent kinases in regulating cell cycle progression * Provide examples of disordered signaling in cancer * Describe checkpoints and how they regulate the correct expression of the cell cycle * Understand the role of apoptosis in preventing inappropriate cell proliferation
Michael Jardine
Quiz von Michael Jardine, aktualisiert more than 1 year ago
Michael Jardine
Erstellt von Michael Jardine vor etwa 7 Jahre
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Zusammenfassung der Ressource

Frage 1

Frage
What is the difference between cell growth and cell proliferation?
Antworten
  • Cell growth = increase in ONE cell's mass/size; Cell proliferation = increase in cell numbers.
  • Cell growth = increase in cell numbers; Cell proliferation = increase in ONE cell's mass/size.
  • No meaningful distinction. (/ distinction without substantial difference) (/ fuck all)

Frage 2

Frage
Which of the following is true?
Antworten
  • Control of cell proliferation is intrinsically linked to cell growth.
  • Control of cell growth is intrinsically linked to cell proliferation.

Frage 3

Frage
The order of the rough phases of the cell cycle are as follows: G1 > [blank_start]_____[blank_end] > [blank_start]_____[blank_end] > [blank_start]_____[blank_end] > [blank_start]_____[blank_end] (then back to G1 again)
Antworten
  • S
  • G2
  • M
  • Cytokinesis

Frage 4

Frage
G1 phase stands for, and involves, what?
Antworten
  • Growth phase
  • Gap phase
  • Cell growth
  • Monitoring
  • Mitosis

Frage 5

Frage
G2 phase stands for, and involves, what?
Antworten
  • Growth phase
  • Gap phase
  • Cell growth
  • Monitoring
  • Mitosis

Frage 6

Frage
S phase stands for, and involves, what?
Antworten
  • DNA synthesis
  • Selectivity
  • Cell growth
  • Mitosis
  • Stretching

Frage 7

Frage
M phase stands for, and involves, what?
Antworten
  • Mitosis
  • Meiosis
  • Monitoring
  • DNA synthesis
  • Cell division

Frage 8

Frage
Cdks (Cyclin-Dependent KinaseS) are regulated by:
Antworten
  • Cyclins
  • Phosphorylation
  • Both of the above
  • [none of the above]

Frage 9

Frage
Mitogens are:
Antworten
  • Things that stimulate cell division (e.g. hormones, cytokines).
  • Stimulate migration.

Frage 10

Frage
Disordered signaling in cancer. Many cancer-critical genes (oncogenes or tumour-suppressor genes) regulate cell growth and proliferation. e.g. a mutation may lead to independence from mitogen-dependence. Acquiring the ability to synthesise mitogens (resulting in autocrine stimulation) is one way this can happen. Some examples of this are:
Antworten
  • PDGF, TGFα - glioblastomas & osteosarcoma
  • EGF-R/erbB (epidermal growth factor receptor); HER2 (human epidermal growth factor receptor)

Frage 11

Frage
Disordered signaling in cancer. Many cancer-critical genes (oncogenes or tumour-suppressor genes) regulate cell growth and proliferation. e.g. a mutation may lead to independence from mitogen-dependence. Constitutive expression of their receptors (resulting in increased sensitivity?) is one way this can happen. Some examples of this are:
Antworten
  • PDGF, TGFα - glioblastomas & osteosarcoma
  • EGF-R/erbB (epidermal growth factor receptor); HER2 (human epidermal growth factor receptor)

Frage 12

Frage
HER2 (Human Epidermal growth factor Receptor) mutations are present in:
Antworten
  • Overexpressed in breast cancer.
  • Overexpressed in stomach, brain, and breast cancer.
  • Abnormally present in glioblastomas and osteosarcoma.

Frage 13

Frage
EGF-R / erbB (Epidermal Growth Factor Receptor) and cancer...
Antworten
  • Up-regulated in stomach, brain, and breast cancer.
  • Up-regulated in breast cancer.
  • Abnormally present in gliobastomas & osteosarcoma.

Frage 14

Frage
True or false: Mitogens [usually?] act through the ras/raf/ERK cascade.
Antworten
  • True
  • False
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