10320480
Beschreibung
Quiz von Michael Jardine, aktualisiert more than 1 year ago
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Erstellt von Michael Jardine
vor mehr als 7 Jahre
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Frage 1
Frage
True or false:
Cells which have entered senescence have a large, flattened morphology "like poached eggs".
Antworten
- True
- False
Frage 2
Frage
Mutations in p53 and/or Rb can lead to:
Antworten
-
Bypassing senescence and crisis.
-
Bypassing senescence and entering crisis.
-
Entering crisis.
-
[none of the above]
Frage 3
Frage
Cells in "crisis" have which of the following traits?
(select all that apply)
Antworten
-
Massive cell death
-
Reduced cell death
-
Increased genomic stability
-
Genomic instability
Frage 4
Frage
The Hayflick limit is:
Antworten
-
The number of divisions a cell can undergo before entering senescence.
-
(not this one)
Frage 5
Frage
Telomeres shorten by ~[blank_start]_____[blank_end] bp with each round of cell division.
Antworten
-
5 - 15
-
50 - 150
-
500 - 1,500
-
5,000 - 15,000
-
130 - 210
-
2,000 - 40,000
Frage 6
Frage
There are two [main?] telomere maintenance mechanisms. These are Telomerase and ALT.
What does ALT stand for?
[blank_start]_____[blank_end]
Antworten
-
Alternative Lengthening of Telomeres
Frage 7
Frage
Which [non-cancerous] cell type does NOT have shortening telomeres during replication?
Antworten
-
Germ line cells
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Stem cells
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Cardiomyocytes
Frage 8
Frage
Telomerase is:
Antworten
-
An enzyme
-
A protein
-
A molecule
Frage 9
Frage
Which telomere maintenance mechanism is used in the majority of cancers?
Antworten
-
Telomerase
-
ALT
Frage 10
Frage
Telomerase can be detected using which of the following methods:
(select all that apply)
Antworten
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TRAP (Telomere Repeat Amplification Protocol) assay
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TRF (Terminal Restriction Fragment) assay
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APBs (ALT-associated PML Bodies)
-
C-circle assay
-
Movement of the telomere tag
Frage 11
Frage
ALT can be detected using which of the following methods?
(select all that apply)
Antworten
-
TRAP (Telomere Repeat Amplification Protocol) assay
-
TRF (Terminal Restriction Fragment) assay
-
APBs (ALT-associated PML Bodies)
-
C-circle assay
-
Movement of the telomere tag
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