Zusammenfassung der Ressource
Frage 1
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Which of these effects are where?
Antworten
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Skeletal Muscle
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Adipose Tissue
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Liver
Frage 2
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Actions of Insulin. Insulin stimulates and inhibits various things. Which are STIMULATED?
Antworten
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Glucose transport (muscle, adipose)
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Glycogen synthesis (muscle, adipose, liver)
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Lipogenesis (adipose, liver)
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FA transport (muscle, adipose)
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Complex lipid synthesis (muscle, adipose, liver)
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Protein synthesis (all tissues)
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Amino acid transport (all tissues)
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Protein degradation (all tissues)
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Gluconeogenesis & Glycogenolysis (liver)
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Lipolysis (adipose, muscle?)
Frage 3
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Actions of Insulin. Insulin stimulates and inhibits various things. Which are INHIBITED?
Antworten
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Glucose transport (muscle, adipose)
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Glycogen synthesis (muscle, adipose, liver)
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Lipogenesis (adipose, liver)
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FA transport (muscle, adipose)
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Complex lipid synthesis (muscle, adipose, liver)
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Protein synthesis (all tissues)
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Amino acid transport (all tissues)
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Protein degradation (all tissues)
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Gluconeogenesis & Glycogenolysis (liver)
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Lipolysis (adipose, muscle?)
Frage 4
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Definition of Insulin Resistance. There are three of them. Which is which?
“The inability of a known quantity of exogenous or endogenous insulin to increase glucose uptake and utilisation in an individual as much as it does in a normal population.” = the [blank_start]__________[blank_end] definition.
“The inability of exogenous insulin to alter post-translational modifications (e.g. phosphorylation) of specific proteins in tissue or cells.” = the [blank_start]__________[blank_end] definition.
“The inability of exogenous or endogenous insulin to increase glucose uptake in tissues or cultured cells.” = the [blank_start]__________[blank_end] definition.
Antworten
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Clinical
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“Sometimes”
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Experimental
Frage 5
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Loss of function of IR in skeletal muscle results in which of the following:
Frage 6
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Insulin resistance results from a fuck-up in which of the following:
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Insulin Receptor
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Insulin Transporter
Frage 7
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Loss of function of Glut4 in Skeletal Muscle results in which of the following:
Frage 8
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Knockout of the Insulin Receptor in ADIPOSE TISSUE is known as which of the following:
Frage 9
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True or false: FIRKO results in INCREASED insulin sensitivity in adipose tissue.
Frage 10
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True or false: FIRKO results in DECREASED insulin sensitivity in adipose tissue.
Frage 11
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True or false: Knockout of the Insulin Receptor in adipose tissue results in an INCREASE of weight! True? True.
Frage 12
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Loss of function of Glut4 in ADIPOSE TISSUE results in which of the following:
Antworten
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Reduced adipocyte glucose uptake
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Reduced insulin suppression of HGP
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Increased insulin suppression of HGP
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Whole-body glucose intolerance and insulin resistance
Frage 13
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LIRKO results in which of the following:
Frage 14
Frage 15
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“The” Mechanism(s). “The” mechanism of insulin resistance is which of the following:
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Reduced Insulin Receptor (IR) levels
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Reduced Glut4 levels
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Inappropriate translocation of Glut4 to the plasma membrane
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Inappropriate translocation of IR to the plasma membrane
Frage 16
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Insulin resistance is caused by many factors including: