PHSI3012 11-2 Insulin Resistance (T3L4)

Beschreibung

PHSI3012 11-2 Insulin Resistance (T3L4)
Michael Jardine
Quiz von Michael Jardine, aktualisiert more than 1 year ago
Michael Jardine
Erstellt von Michael Jardine vor fast 7 Jahre
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Zusammenfassung der Ressource

Frage 1

Frage
Which of these effects are where?
Antworten
  • Skeletal Muscle
  • Adipose Tissue
  • Liver

Frage 2

Frage
Actions of Insulin. Insulin stimulates and inhibits various things. Which are STIMULATED?
Antworten
  • Glucose transport (muscle, adipose)
  • Glycogen synthesis (muscle, adipose, liver)
  • Lipogenesis (adipose, liver)
  • FA transport (muscle, adipose)
  • Complex lipid synthesis (muscle, adipose, liver)
  • Protein synthesis (all tissues)
  • Amino acid transport (all tissues)
  • Protein degradation (all tissues)
  • Gluconeogenesis & Glycogenolysis (liver)
  • Lipolysis (adipose, muscle?)

Frage 3

Frage
Actions of Insulin. Insulin stimulates and inhibits various things. Which are INHIBITED?
Antworten
  • Glucose transport (muscle, adipose)
  • Glycogen synthesis (muscle, adipose, liver)
  • Lipogenesis (adipose, liver)
  • FA transport (muscle, adipose)
  • Complex lipid synthesis (muscle, adipose, liver)
  • Protein synthesis (all tissues)
  • Amino acid transport (all tissues)
  • Protein degradation (all tissues)
  • Gluconeogenesis & Glycogenolysis (liver)
  • Lipolysis (adipose, muscle?)

Frage 4

Frage
Definition of Insulin Resistance. There are three of them. Which is which? “The inability of a known quantity of exogenous or endogenous insulin to increase glucose uptake and utilisation in an individual as much as it does in a normal population.” = the [blank_start]__________[blank_end] definition. “The inability of exogenous insulin to alter post-translational modifications (e.g. phosphorylation) of specific proteins in tissue or cells.” = the [blank_start]__________[blank_end] definition. “The inability of exogenous or endogenous insulin to increase glucose uptake in tissues or cultured cells.” = the [blank_start]__________[blank_end] definition.
Antworten
  • Clinical
  • “Sometimes”
  • Experimental

Frage 5

Frage
Loss of function of IR in skeletal muscle results in which of the following:
Antworten
  • Reduced Skeletal Muscle glucose uptake
  • Whole-body glucose intolerance and insulin resistance

Frage 6

Frage
Insulin resistance results from a fuck-up in which of the following:
Antworten
  • Insulin Receptor
  • Insulin Transporter

Frage 7

Frage
Loss of function of Glut4 in Skeletal Muscle results in which of the following:
Antworten
  • Reduced Skeletal Muscle glucose uptake
  • Whole-body glucose intolerance and insulin resistance

Frage 8

Frage
Knockout of the Insulin Receptor in ADIPOSE TISSUE is known as which of the following:
Antworten
  • MIRKO
  • FIRKO
  • LIRKO
  • AIRKO

Frage 9

Frage
True or false: FIRKO results in INCREASED insulin sensitivity in adipose tissue.
Antworten
  • True
  • False

Frage 10

Frage
True or false: FIRKO results in DECREASED insulin sensitivity in adipose tissue.
Antworten
  • True
  • False

Frage 11

Frage
True or false: Knockout of the Insulin Receptor in adipose tissue results in an INCREASE of weight! True? True.
Antworten
  • True
  • False

Frage 12

Frage
Loss of function of Glut4 in ADIPOSE TISSUE results in which of the following:
Antworten
  • Reduced adipocyte glucose uptake
  • Reduced insulin suppression of HGP
  • Increased insulin suppression of HGP
  • Whole-body glucose intolerance and insulin resistance

Frage 13

Frage
LIRKO results in which of the following:
Antworten
  • Loss of insulin suppression of HGP
  • Whole-body glucose intolerance and insulin resistance

Frage 14

Frage
HGP = ??
Antworten
  • Hepatic Glucose Production
  • HypoGonadotroPin
  • Haematic Glucose Production

Frage 15

Frage
“The” Mechanism(s). “The” mechanism of insulin resistance is which of the following:
Antworten
  • Reduced Insulin Receptor (IR) levels
  • Reduced Glut4 levels
  • Inappropriate translocation of Glut4 to the plasma membrane
  • Inappropriate translocation of IR to the plasma membrane

Frage 16

Frage
Insulin resistance is caused by many factors including:
Antworten
  • Ectopic lipid deposition
  • Inflammation
  • Mitochondrial oxidative stress
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