Cholesterol is a 26-Carbon sterol lipid that’s synthesised through a complex 37-step process.
It composes [blank_start]__________[blank_end] of cell membranes.
Circulating cholesterol arises from the diet as well as from [blank_start]__________[blank_end] synthesis.
It circulates mostly as Cholesterol Ester (cholesterol + FA).
Answer
10%
30%
50%
70%
90%
Intracellular
Extracellular
Intercellular
Question 2
Question
Familial Hypercholesterolaemia is a family of pathologies that range from heterozygous to homozygous. It’s characterised by [blank_start]__________[blank_end] [blank_start]__________[blank_end] levels. Caused by a loss of LDL-R.
Answer
Increased
Decreased
LDL-Chol
HDL-Chol
Question 3
Question
Lysosomal Storage Disease (aka Niemann-Pick disease type C) is a collection of ~50 rare inherited metabolic pathologies. Its hallmark is defective lysosomal function. It’s characterised by [blank_start]__________[blank_end] [blank_start]__________[blank_end] in the lysosome due to the loss of function of NPC1 and/or NPC2.
Answer
Free cholesterol
FFA
TAG
Accumulation
Dissipation
Question 4
Question
The highly proliferative nature of cancer cells means they have increased metabolic requirements, especially of which two things?
Answer
Energy
Phospholipids
Question 5
Question
In cancer, metabolism changes.
De Novo Cholesterol [blank_start]__________[blank_end] [blank_start]__________[blank_end];
De Novo Lipid [blank_start]__________[blank_end] [blank_start]__________[blank_end].
Answer
Synthesis AND uptake
Synthesis
Uptake
Increases
Decreases
Increases
Decreases
Synthesis AND uptake
Synthesis
Uptake
Question 6
Question
Prostate cancer growth is [primarily?] driven by [blank_start]__________[blank_end].
It’s a [blank_start]__________[blank_end] metabolism cancer and is greatly dependent on [blank_start]__________[blank_end].
Answer
Androgens
Non-Warburg
Warburg
Fatty Acid oxidation
Reactive Oxygen Species
Cholesterol oxidation
Question 7
Question
CRPC = ??
Answer
Castration-Resistant Prostate Cancer
Castratian-Resistant Prostate Cancer
Question 8
Question
Gene Expression of Steroidogenic Enzymes is [blank_start]__________[blank_end] in CRPC.