PHSI3012 10-2 Disorders of Lipid Metabolism #2 (T3L2)

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PHSI3012 10-2 Disorders of Lipid Metabolism #2 (T3L2)
Michael Jardine
Quiz by Michael Jardine, updated more than 1 year ago
Michael Jardine
Created by Michael Jardine almost 7 years ago
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Resource summary

Question 1

Question
Cholesterol is a 26-Carbon sterol lipid that’s synthesised through a complex 37-step process. It composes [blank_start]__________[blank_end] of cell membranes. Circulating cholesterol arises from the diet as well as from [blank_start]__________[blank_end] synthesis. It circulates mostly as Cholesterol Ester (cholesterol + FA).
Answer
  • 10%
  • 30%
  • 50%
  • 70%
  • 90%
  • Intracellular
  • Extracellular
  • Intercellular

Question 2

Question
Familial Hypercholesterolaemia is a family of pathologies that range from heterozygous to homozygous. It’s characterised by [blank_start]__________[blank_end] [blank_start]__________[blank_end] levels. Caused by a loss of LDL-R.
Answer
  • Increased
  • Decreased
  • LDL-Chol
  • HDL-Chol

Question 3

Question
Lysosomal Storage Disease (aka Niemann-Pick disease type C) is a collection of ~50 rare inherited metabolic pathologies. Its hallmark is defective lysosomal function. It’s characterised by [blank_start]__________[blank_end] [blank_start]__________[blank_end] in the lysosome due to the loss of function of NPC1 and/or NPC2.
Answer
  • Free cholesterol
  • FFA
  • TAG
  • Accumulation
  • Dissipation

Question 4

Question
The highly proliferative nature of cancer cells means they have increased metabolic requirements, especially of which two things?
Answer
  • Energy
  • Phospholipids

Question 5

Question
In cancer, metabolism changes. De Novo Cholesterol [blank_start]__________[blank_end] [blank_start]__________[blank_end]; De Novo Lipid [blank_start]__________[blank_end] [blank_start]__________[blank_end].
Answer
  • Synthesis AND uptake
  • Synthesis
  • Uptake
  • Increases
  • Decreases
  • Increases
  • Decreases
  • Synthesis AND uptake
  • Synthesis
  • Uptake

Question 6

Question
Prostate cancer growth is [primarily?] driven by [blank_start]__________[blank_end]. It’s a [blank_start]__________[blank_end] metabolism cancer and is greatly dependent on [blank_start]__________[blank_end].
Answer
  • Androgens
  • Non-Warburg
  • Warburg
  • Fatty Acid oxidation
  • Reactive Oxygen Species
  • Cholesterol oxidation

Question 7

Question
CRPC = ??
Answer
  • Castration-Resistant Prostate Cancer
  • Castratian-Resistant Prostate Cancer

Question 8

Question
Gene Expression of Steroidogenic Enzymes is [blank_start]__________[blank_end] in CRPC.
Answer
  • Increased
  • Decreased
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