Question 1
Question
How many ATPs go where?
(btw, "1 ATP" goes before "1ATP")
Answer
-
2 ATP
-
2ATP
-
ATP
-
4 ATP
-
36 ATP
-
129 ATP
Question 2
Question
Free fatty acids (NEFA / Non-Esterified Fatty Acids) vs TriAcylGlycerides (/TAGs).
[blank_start]__________[blank_end] circulate bound to albumin.
[blank_start]__________[blank_end] circulate within [blank_start]__________[blank_end] released from the liver or [blank_start]__________[blank_end] released from the gut.
Answer
-
NEFA
-
TAGs
-
VLDLs
-
Chylomicrons
Question 3
Question
Lipid uptake.
Put the three in order (they’re written alphabetically here)
[blank_start]__________[blank_end] Cholesterol-rich LDL interact with LDL-R and scavenger receptors; enters lysosomal pathway for hydrolysis;
[blank_start]__________[blank_end] Hepatic Lipase and Lipoprotein Lipase reside on endothelial cells to hydrolyse VLDL and Chylomicron TAG to FFAs for uptake;
[blank_start]__________[blank_end] TAG-rich VLDL interact with VLDL-R, enters lysosomal pathway where acid lipases hydrolyse TAG.
Question 4
Question
Familial Lipoprotein Lipase Deficiency is:
Answer
-
Autosomal DOMINANT
-
Autosomal RECESSIVE
Question 5
Question
LPL deficiency causes [blank_start]__________[blank_end], which leads to [blank_start]__________[blank_end].
Question 6
Question
Fatty Acid Metabolism has two major pathways: TriAcylGlycerol metabolism and β-Oxidation.
FA uptake is a 2-step process. In which order does it happen?
Question 7
Answer
-
Consumes 1 ATP
-
Is irreversible
-
Is reversible
-
Consumes 2 ATP
-
Consumes 4 ATP
-
Consumes 36 ATP
Question 8
Question
De Novo Fatty Acid Synthesis uses [blank_start]__________[blank_end] (from Glucose and Amino acids) to generate [blank_start]__________[blank_end] as the starting substrate to firstly produce [blank_start]__________[blank_end] (C16:O).
Answer
-
Citrate
-
Acetyl-CoA
-
Malonyl-CoA
-
Palmitate
Question 9
Question
De Novo Fatty Acid Synthesis uses up how many ATP molecules?
Question 10
Question
CPT1 turns Carnitine into FA-Carnitine, allowing it to be uptaken into a cell. This can be blocked by which of the following?
Question 11
Question
MCD deficiency (and some similar disorders) prevent [blank_start]__________[blank_end] from being turned into [blank_start]__________[blank_end]. This results in [blank_start]__________[blank_end] of CPT1 (and thus [blank_start]__________[blank_end] FA uptake).
Answer
-
Malonyl-CoA
-
Acetyl-CoA
-
Blockage
-
Stimulation
-
Reduces
-
Increases
Question 12
Question
What goes where?
(within each box, put the two in alphabetical order)
Answer
-
Adipose-derived Fatty Acids
-
Chylomicron-derived Fatty Acids
-
De novo Lipogenesis
-
Re-esterification
-
Fatty Acid Oxidation
-
TAG Secretion (e.g. VLDL)