11677938
Beschreibung
Quiz von Melanie Grynsztejn, aktualisiert more than 1 year ago
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Erstellt von Melanie Grynsztejn
vor mehr als 6 Jahre
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Frage 1
Frage
Which beta blockers block both beta & alpha receptors?
Antworten
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Labetol
-
Carvedilol
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Propanolol
-
Metroprolol
Frage 2
Frage
Beta‐1, found primarily in [blank_start]heart muscle[blank_end], results in increased heart rate, contractility, and atrioventricular (AV) conduction
Antworten
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heart muscle
-
bronchial & peripheral smooth muscle
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adipose
Frage 3
Frage
Beta‐2, found in [blank_start]bronchial and peripheral vascular[blank_end] smooth muscle; results in vasodilatation and bronchodilation.
Antworten
-
bronchial and peripheral vascular
-
heart muscle
-
adipose
Frage 4
Frage
Beta‐3, found in [blank_start]adipose tissue and the heart;[blank_end] may reduce cardiac contractility.
Antworten
-
adipose tissue and the heart;
-
heart muscle
-
bronchial and peripheral vascular smooth
Frage 5
Frage
Beta blockers MOA:
Antworten
-
Competitively inhibiting catecholamines from binding to these receptors.
-
Dilate veins, arteries, and coronary arteries by relaxing vascular smooth muscle
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Act on vascular smooth muscle to reduce contraction of the arteries and cause vasodilation
Frage 6
Frage
Which of the following Beta Blockers are eliminated by hepatic metabolism and are lipid soluble
Antworten
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Propranolol
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Metoprolol
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Atenolol
-
Sotalol
Frage 7
Frage
Why is important to know which BB are eliminated by hepatic metabolism and more lipid soluble?
Antworten
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Enter CNS in high concentrations, possibly resulting in an increased incidence of CNS side effects
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Are eliminated and do not as readily enter the CNS so can be prescribed more readily
-
Can cause hepatic damage if prescribed in too high a dosage
Frage 8
Frage
Which of the following beta blockers are excreted unchanged by the kidney?
Antworten
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Atenolol
-
Sotalol
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Propranolol
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Metoprolol
Frage 9
Frage
Metoprolol tartrate is [blank_start]shorter‐acting[blank_end] and dose [blank_start]*twice*[blank_end] daily and
Metoprolol succinate [blank_start]longer‐ acting[blank_end] and dosed [blank_start]*once*[blank_end] daily
Antworten
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shorter‐acting
-
longer-acting
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*twice*
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*once*
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longer‐ acting
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shorter-acting
-
*once*
-
*twice*
Frage 10
Frage
Atenolol and sotalol are more water soluble and are eliminated unchanged by the kidney. What is the effect of this on plasma half-lives & bioavailability?
Antworten
-
Longer plasma half-life
-
Shorter plasma half-life
-
Greater bioavailability
-
Lesser bioavailability
Frage 11
Frage
True or False:
BB are first-line therapy to reduce angina episodes & increase exercise tolerance
Antworten
- True
- False
Frage 12
Frage
BB & CCB are antianginal drugs proven to prevent reinfarction and improve survival in patients who have sustained a MI
Antworten
- True
- False
Frage 13
Frage
BB should NOT be used in which type of angina patient
Antworten
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Stable
-
Unstable
-
Vasospastic (Prinzmetal)
Frage 14
Frage
It is important to [blank_start]taper[blank_end] BB when discontinuing BB therapy
Antworten
-
taper
Frage 15
Frage
What are some potential Adverse Effects of Beta Blockers
Antworten
-
Decreased heart rate, contractility & AV node conduction
-
Increased heart rate, contractility & AV node conduction
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Bronchoconstriction
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Bronchodilation
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Nightmares, Insomnia, hallucinations
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Depression
-
Weight loss
-
Weight gain
-
Erectile dysfunction
Frage 16
Frage
T or F
CCB are less effective than BB when treating stable angina
Antworten
- True
- False
Frage 17
Frage
When are CCB used to treat stable angina?
Antworten
-
When BB is not successful
-
When BB is contraindicated
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When BB are causing SE
-
Are never combined with BB
Frage 18
Frage
What is the caution for using both non‐dihydropyridine and BB?
Antworten
-
Additive bradycardia
-
Orthostatic hypotension
-
Weakness
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N/V/D
Frage 19
Frage
CCB improve anginal symptoms by causing coronary and [blank_start]peripheral[blank_end] vasodilatation and [blank_start]reducing[blank_end] contractility
Antworten
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peripheral
-
central
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reducing
-
increasing
Frage 20
Frage
Select the non-dihydropyridine CCB:
Antworten
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Diltiazem
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Verapamil
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Amlodipine
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Felodipine
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Nifedipine
Frage 21
Frage
Which types of CCB are preferred for angina
Antworten
-
Long-acting non-dihydropyridine CCB - Verapamil & Diltiazem
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Second generation CCB - Amlodipine or Felodipine
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1st generation CCB - Nifidepine
Frage 22
Frage
What is the most concerning adverse effect of dihyrdropyridine (amlodipine, felodipine, nifedipine
Antworten
-
Peripheral edema
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Lightheadedness
-
Flushing
Frage 23
Frage
What are potential adverse effects of Dihydropyridines
Antworten
-
Constipation
-
Bradycardia
-
Peripheral edema
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Lightheadness
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Flushing
-
Headache
Frage 24
Frage
What are potential adverse effects of non-dihydropyridines
Antworten
-
Bradycardia
-
Constipation
-
Peripheral edema
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Headache
-
Lightheadedness
-
Flushing
Frage 25
Frage
What are a prescribers options if a patient gets peripheral edema on a dihydropyridines?
Antworten
-
Reduce dose
-
Add an angiotensin‐converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB)
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Switch to a non‐dihydropyridine agent
-
Add a metered dose spray nitrate
Frage 26
Frage
MOA for nitrate used for stable angina is
Antworten
-
Dilate veins, arteries, and coronary arteries by relaxing vascular smooth muscle.
-
Competitively inhibiting catecholamines from binding to these receptors.
-
Act on vascular smooth muscle reducing contraction of the arteries and causing vasodilation
Frage 27
Frage
Select the cardioselective beta blockers
Antworten
-
Atenolol
-
Metoprolol
-
Propranolol
Frage 28
Frage
Select the non-cardioselective beta blockers
Antworten
-
Meoprolol
-
Atenolol
-
Propranolol
Frage 29
Frage
Nitrates are used as
Antworten
-
First‐line therapy for the treatment of acute anginal
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Prophylactically for activities known to elicit angina
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Ongoing management of stable angina
Frage 30
Frage
Usually in the form of a sublingual preparation, nitrates onset of action is within [blank_start]2‐5 minutes[blank_end] and duration of action [blank_start]15‐30 minutes[blank_end]
Antworten
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2‐5 minutes
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5 - 10 minutes
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1 - 2 minutes
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15 ‐ 30 minutes
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5 - 10 minutes
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10 - 20 minutes
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15 - 20 minutes
Frage 31
Frage
Select the potential adverse effects of nitrates
Antworten
-
Hypotension
-
Flushing
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Bradycardia
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Headache
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N/V/D
-
LIghtheadedness
Frage 32
Frage
American College of Cardiology/American Heart Association (ACC/AHA) guidelines for calling the emergency services are
Antworten
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Contact EMS if chest pain or discomfort is unimproved or worsening 5 minutes after *one* nitroglycerin dose has been taken sublingually
-
Take one nitroglycerin dose sublingually every 5 minutes for up to *3 doses* before calling for emergency medical services evaluation.
Frage 33
Frage
Nitroglycerin tablets are both [blank_start]heat[blank_end] and [blank_start]light[blank_end] sensitive
Antworten
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heat
-
light
Frage 34
Frage
Nitroglycerin tablets should be stored in a tightly capped dark bottle in the refrigerator with only a small supply being carried by the patient and discarded after 12 months
Antworten
- True
- False
Frage 35
Frage
The following are longer-acting nitrate therapies
Antworten
-
Nitroglycerin table
-
Isosorbide dinitrate
-
Isosorbide mononitrate
-
Transdermal nitroglycerin patch
Frage 36
Frage
How can a patient address the issue of nitrate tolerance with long-term therapies like the transdermal nitroglycerin patch?
Antworten
-
Nitrate‐free interval (at least approx 8‐10 hours)
-
Use patch on different sites on the body
-
Increase dosage of transdermal patch
-
Switch to short-term nitroglycerin tablet
Frage 37
Frage
What is a REALLY IMPORTANT nitrate contraindication drug
Antworten
-
Warfarin (Coumadin)
-
Erectile dysfunction drugs, PDE-5, Sildenafil, Vardenafil or Tadalafil within 24 hours
-
Second generation dihydropyridine CCB drugs Amlodipine and Felodipine
-
Cardioselective BB drugs Atenolol and Metoprolol
Frage 38
Frage
Ranolazine is a new drug for stable angina that is recommended for patients that have failed all other antianginal therpies. However, it is contraindicated for the following patients
Antworten
-
Pre-existing QT interval
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Hepatic disease
-
Renal disease
-
Tachycardia
Frage 39
Frage
The following are angina PREVENTIVE therapies
Antworten
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ASA
-
Clopidogrel (Plavix) if allergic to aspirin
-
Verapamil if allergic to aspirin
-
Propranolol if allergic to aspiring
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