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In terms of sleeping, there are both REM and non-REM cycles. What does 'REM' stand for?
[blank_start]Rapid eye movement[blank_end]
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Which sleep type is most associated with dreaming?
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The average adult spends 75% of their sleep in REM cycles and 25% in non-REM cycles
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Which type of sleep is similar to wakefulness?
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Which type of sleep is most important for protein synthesis, cell division and growth?
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Melatonin is one of the main regulators of the circadian rhythm (along with cortisol level and low body temperature). Where is melatonin produced?
The [blank_start]Pineal Gland[blank_end]
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Light entrains the circadian rhythm in humans:
Retinal [blank_start]ganglion[blank_end] cells project information to the [blank_start]suprachiasmatic[blank_end] nucleus in the hypothalamus to regulate sleep-wake cycles.
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ganglion
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bipolar
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horizontal
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amacrine
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Suprachiasmatic
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Preoptic
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Paraventricular
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Arcuate nucleus
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What is considered the most important stage of sleep, allowing the cerebral hemispheres to effectively 'rest'?
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Light Non-REM sleep
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Deep Non-REM sleep
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REM sleep
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A mid afternoon nap of 15 minutes is equivalent to 90 minutes overnight
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Most studies suggest that 6-6.5 hours of sleep per night is acceptable for adults
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[blank_start]Narcolepsy[blank_end] is a sleep disorder that is characterized by excessive sleepiness, sleep attacks, sleep paralysis, hallucinations and, for some, sudden loss of muscle control
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The episodes of sudden muscle tone loss that is associated with 70% of narcolepsy patients is known as [blank_start]cataplexy[blank_end]
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Cataplexy is a sudden loss of muscle tone in response to ...
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An emotion such as fear, surprise or joy
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A transient drop in blood pressure caused by activities such as standing up too quickly
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Hallucinations that tend to occur spontaneously throughout the day
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A sudden temperature drop
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Narcolepsy with cataplexy has a known cause: a loss of cells in the brain that secrete a hormone responsible for wakefulness called ...
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Hypocretin
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Hippocretin
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Melatonin
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Hypotonin
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Investigations for Narcolepsy:
[blank_start]Overnight Polysomnography[blank_end]: A comprehensive recording of the biophysiological changes that occur during a normal sleep duration
[blank_start]Multiple Sleep Latency Test[blank_end]: Four 25 minute naps around 2 hours apart in order to test brain activity and eye movement
[blank_start]Lumbar puncture[blank_end]: Measures the levels of Hypocretin being produced by the brain
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What is REM Behaviour Disorder (RBD)?
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A disorder whereby people act out their dreams. The normal atonic nature of muscles during REM sleep is not present.
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A disorder whereby people actively dream during the day. Like narcolepsy, this condition is also related to hypocretin levels in the brain.
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A condition whereby an individual wakes up upon initiation of REM sleep, meaning they must sleep in smaller sections and can never get a full night's sleep.
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Which hormone supplement can be given to REM Behaviour Disorder patients in attempt to improve their sleep?
[blank_start]Melatonin[blank_end]
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Which of the following is the most commonly prescribed medication to treat Narcolepsy?
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Modafinil
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Sodium Oxybate
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Fluoxetine
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Amitriptyline