Frage 1
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[blank_start]Healing[blank_end] is the body's replacement of destroyed tissue by [blank_start]living[blank_end] tissue
Frage 2
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Repair can occur in three ways: [blank_start]Resolution[blank_end], [blank_start]Regeneration[blank_end] and Organisation.
Frage 3
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Resolution only occurs if tissue sustained [blank_start]minimal[blank_end] damage - inflammatory reactions [blank_start]occur[blank_end] -> tissue is [blank_start]restored[blank_end] to former function and structure
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minimal
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maximal
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occur
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doesn't occur
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restored
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doesn't restore
Frage 4
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Regeneration are usually in tissues where cells have [blank_start]mitotic[blank_end] ability. [blank_start]Labile[blank_end] cells are ones that continue to [blank_start]multiply[blank_end] in order to [blank_start]replace[blank_end] lost cells, whilst [blank_start]stable[blank_end] cells cease to multiply when growth of mature organ is reached.
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mitotic
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Labile
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stable
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replace
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multiply
Frage 5
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Organisation is where damage is [blank_start]severe[blank_end] and [blank_start]cell loss[blank_end] is great. Inflammatory response [blank_start]subsides[blank_end], [blank_start]damage[blank_end] is so great, [blank_start]granulation tissue[blank_end] forms and matures to form a [blank_start]scar[blank_end]. Especially in tissues composed of permanent cells with no [blank_start]mitotic ability[blank_end] such as [blank_start]neurons[blank_end].
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severe
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cell loss
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subsides
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increases
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granulation tissue
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damage
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haemorrhage
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scar
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mitotic ability
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neurons
Frage 6
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[blank_start]Regeneration[blank_end] and [blank_start]hyperplasia[blank_end] both show cell division. These are both kept under control compared to neoplasia. [blank_start]Regeneration[blank_end] is the replacement of lost cells, not more cells. [blank_start]Hyperplasia[blank_end] is the excessive multiplication of cells which results in larger amount of tissue than normal.
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Regeneration
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organisation
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Hyperplasia
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hypoplasia
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Regeneration
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hyperplasia
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hyperplasia
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regeneration
Frage 7
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There are 2 ways a skin wound will heal - [blank_start]First intension[blank_end]: Clean, precise [blank_start]lesion[blank_end] and also the Second intension: There is [blank_start]tissue loss[blank_end]
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First intension
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lesion
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tissue loss
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tissue gain
Frage 8
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Healing by first intension - There is [blank_start]no infection[blank_end], and edges of wound are held [blank_start]together[blank_end] by sutures or butterfly tape.
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no infection
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infection
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together
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apart
Frage 9
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All of the below are first intension healing 1 except
Frage 10
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In first intension healing 2, [blank_start]epithelium[blank_end] begins to grow in from the edges and comes together within 2 days, and formation of epithelial spur. Epithelial growth stimulates a minimal amount of [blank_start]granulation tissue[blank_end] from surrounding connective tissue. Fibroblasts start to lay down [blank_start]collagen[blank_end], and wound edges [blank_start]unite[blank_end].
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epithelium
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granulation tissue
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collagen
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unite
Frage 11
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First intension healing 3 includes
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Epithelial spur resorption
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decreasing vascularity
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collagen slowly transformed from type III to I
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unification of wound edges
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scab formation
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increasing vascularity
Frage 12
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In healing by second intension, the [blank_start]wound[blank_end] gapes and there is [blank_start]loss[blank_end] of tissue due to infection. First stage is that there's an [blank_start]open[blank_end] and excised wound, [blank_start]bleeding[blank_end] into wound and there are blood clots. Next stage is the [blank_start]growth[blank_end] of new epithelium in from sides and through the clot, and eventually meets in centre. [blank_start]Granulation[blank_end] tissue grows in from adjacent CT and base of wound. [blank_start]Fibroblasts[blank_end] and endothelium
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wound
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scab
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loss
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open
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closed
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bleeding
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growth
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death
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Granulation
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Fibroblasts
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osteoblasts
Frage 13
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Last stage of second intension healing includes wound [blank_start]contraction[blank_end], action of transformed [blank_start]fibroblasts[blank_end], they contrast and [blank_start]collagen[blank_end] is laid down. This in turn [blank_start]reduces[blank_end] wound size. There is also a [blank_start]decrease[blank_end] in vascularity and [blank_start]more collagen[blank_end] is laid down --> [blank_start]fibrous scar[blank_end] formed.
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contraction
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fibroblasts
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chondroblasts
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collagen
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elastin
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reduces
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increases
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decrease
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increase
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more collagen
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more chondroblast
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fibrous scar
Frage 14
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What occurs after wounding 1?
Frage 15
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In after wounding 2, there is [blank_start]hyperplasia[blank_end], and [blank_start]loss[blank_end] of normal cell adherence. There's [blank_start]flattening[blank_end] of rete ridges, and cells slide over each other.
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hyperplasia
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aplasia
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loss
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gain
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flattening
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widening
Frage 16
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In granulation tissue 1, there is [blank_start]proliferation[blank_end] of CT elements, wound is [blank_start]filled[blank_end] and lost tissues are replaced by fibroblasts, venular [blank_start]angioblasts[blank_end] multiply and bud off, whilst [blank_start]macrophage[blank_end] and platelet degradation products are [blank_start]chemotactic[blank_end] for more inflammatory cells.
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proliferation
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ceased growth
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filled
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emptied
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angioblasts
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macrophage
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chemotactic
Frage 17
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Granulation tissue 2 consist of from day 3 appearance of capillary buds and [blank_start]sprouts[blank_end]. They then [blank_start]anastomose[blank_end] with others to flow, start to differentiate into arterioles and venules. Granulation 3 [blank_start]produce[blank_end] types 1 and 3 collagen. Early wound healing first makes [blank_start]hyaluronic[blank_end] acid and sulphated proteoglycans. Granulation tissue 4 consist of total amount of [blank_start]collagen[blank_end] laid down by 3 weeks, and tensile strength of scar tissue increasing by the replacement of type 3 to type 1 collagen. There's a further [blank_start]decrease[blank_end] in vascularity.
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sprouts
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anastomose
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separate
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produce
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destroy
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hyaluronic
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ascorbic
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collagen
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elastin
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decrease
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increase
Frage 18
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Cicatrization is the later [blank_start]reduction[blank_end] in size of the scar
Frage 19
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Skin would consist of