Clinical Immunology Final MCQs- 4th Year- PMU

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Clinical Immunology Final MCQs- 4th Year- PMU
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Zusammenfassung der Ressource

Frage 1

Frage
Which of the following methods is suitable for detectin of serum globulins?
Antworten
  • Nephelometry
  • Radial immnodiffusion by manchini
  • Turbidimetry
  • NBT-test
  • The mantoux test

Frage 2

Frage
Type II allergic reations are realized by
Antworten
  • anaphylaxis
  • complement-mediated cytolysis
  • immune complexes
  • infectious immunity

Frage 3

Frage
Monoclonal antibodies are
Antworten
  • pure population of immunoglobulins with same structure ant antigen specifity
  • albumins that are coded from other group of genes
  • mixed population of immunoglobulins with same structure, but different antigen specifity
  • substrate causing expression of immunoglobulins from other class in B-cells

Frage 4

Frage
Which immunological method is not proper for detecting of specific IgE
Antworten
  • Immuno-enzyme(ELİSA, immuno-blot technique)
  • Classical ones(agglutination, precuipitation)
  • Floucytometry
  • Chemilluminescence

Frage 5

Frage
Low levels of IgA are found in case of
Antworten
  • allergic reaction
  • chronic granulamatosis disease
  • selective IgA deficit
  • macro-globulinemia

Frage 6

Frage
Auto immune disease due to antibodies could be a result of (point the wrong answer)
Antworten
  • forming of antigen-antibody complexes
  • antibodies that blockade cell receptor
  • antibody-depended cell-mediated cytotocicitty(ADCC)
  • cell-mediated reaction

Frage 7

Frage
The name of resident macrophages in liver is
Antworten
  • ostephages
  • lagerhance cells
  • kupfer cells
  • microglial

Frage 8

Frage
EBV can cause
Antworten
  • Hepatoma
  • Nasopharyngeal carcinoma
  • Burkit lymphoma
  • Adenocaqrcinoma pulmonis

Frage 9

Frage
Which of the following indicators is the most important in case of detecting of immune status in AIDS
Antworten
  • NBT test
  • Anti-DNA antibodies
  • CD4/CD8 index
  • The bence-jones protein

Frage 10

Frage
System lupus erythematosus
Antworten
  • is caused by mutations in ds-DNA
  • is revealed with many symptoms and affects many organs
  • is an example of T-cell mediated disease
  • is a result of generating of immune complexes

Frage 11

Frage
The opsonisation is a process of
Antworten
  • Ingestion and destruction of an antigen from phagocyte
  • Of covering of antigen with antibodies in purpose to ease phagocytosis
  • Of covering of antigen with complement in purpose to ease phagoytosis
  • Obtaining of monoclonal antibodies

Frage 12

Frage
Connect with arrows allergic diseases with relevant types allergic reactions: Type [blank_start]3[blank_end] - serum-disease Type [blank_start]4[blank_end] - contact dermatitis Type [blank_start]1[blank_end] - anaphylaxis Type [blank_start]2[blank_end]- hemolytic disease of newborn
Antworten
  • 3
  • 1
  • 2
  • 4
  • 4
  • 1
  • 2
  • 3
  • 1
  • 2
  • 3
  • 4
  • 2
  • 1
  • 3
  • 4

Frage 13

Frage
The mature B-lymphocytes expresses onto their surface
Antworten
  • IgM and IgD
  • IgM and IgA
  • IgD and IgE
  • IgG and IgD

Frage 14

Frage
The lymphocyte infiltration of thyroidea is typical for
Antworten
  • The hashimoto thyroitidis
  • Euthyroid struma
  • Hemolytic anemia
  • Tuberculosis

Frage 15

Frage
The electrophoresis is
Antworten
  • radial immunodiffusion in gel
  • separation of molecules in electric field
  • complement fixation reaction
  • electroimmunodiffusion

Frage 16

Frage
I type allergic reactions are
Antworten
  • Immunocomplex
  • Cytotoxic
  • IgE mediated
  • Cell mediated

Frage 17

Frage
Connect with arrows autoimmune diseases from the left side with relevant characteristics from the right side: wide with relevant characteristics a. Multiple sclerosis [blank_start]6[blank_end] b. SLE [blank_start]4[blank_end] c. Myasthenia gravis [blank_start]5[blank_end] d. Pernicious anemia [blank_start]1[blank_end] e. Hashimoto thyoiditis [blank_start]2[blank_end] f. Hemolytic anemia [blank_start]3[blank_end] 1. autoantibodies against parietal cells of stomach ans intrinsic factor and as a result of this doesn't absorb Vitamin B12 2. autoantibodies against thyroglobuline and thyroid peroxidase 3. antibodies against epitopes of red blood cells 4. antibodies against nucleus antigens 5. antibodies against acetylcholine 6. antibodies against morbidly antigens in liquor and serum, depressed reactions of delayed type hypersensitivity against measles antigens
Antworten
  • 6
  • 1
  • 2
  • 3
  • 4
  • 5
  • 4
  • 1
  • 2
  • 3
  • 5
  • 6
  • 5
  • 1
  • 2
  • 3
  • 4
  • 6
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 2
  • 1
  • 3
  • 4
  • 5
  • 6
  • 3
  • 1
  • 2
  • 4
  • 5
  • 6

Frage 18

Frage
The monoclonal antibodies, connected with diphtheria toxin could be used for
Antworten
  • tumour diagnosis
  • immunostimulation
  • immunosupperession
  • immunotherapy of tumors

Frage 19

Frage
The defensins are
Antworten
  • growth factors
  • antimicrobial peptides in granules of neutrophils
  • cytokines-mediators for immune response

Frage 20

Frage
What is the mechanism of III type allergic reactions
Antworten
  • anaphylaxis
  • complement-mediated cytolsis
  • immune complexes
  • infectious immunity

Frage 21

Frage
Which of the following tumour markers are connected with melanoma maligna?
Antworten
  • CA-15-3
  • gp 120
  • S100B
  • MART-1Melan A

Frage 22

Frage
Immuno-scintigraphy uses monoclonal antibodies against tumour antigen connected with
Antworten
  • FITC
  • Rhodamine
  • Iodine 131, technetium
  • Enzyme

Frage 23

Frage
INF-γ is produced by
Antworten
  • Activated T lymphocytes
  • Fibroblasts
  • B-lymphocytes
  • Leucocytes

Frage 24

Frage
What kind of auto-antibodies we find in patients with insulin-depended sugar diabetes?
Antworten
  • Nucleus
  • Thyroid microsomes
  • IgG molecules
  • Island cells of pancreas

Frage 25

Frage
Rejection of a transplantant due to pre-forming antibodies in recipient is defined as
Antworten
  • Hyper acute rejection
  • Accelerated
  • Acute
  • Chronic

Frage 26

Frage
What of the following possesses the most expressed oncogenic potential
Antworten
  • Influenza virus type A
  • Ebola virus
  • EBV
  • Polioviruses 1,2 ,3
  • HPV

Frage 27

Frage
Is the following correct? Active immunity is a nospecific and is an ancient form of defense and lower degree of effectiveness?
Antworten
  • True
  • False

Frage 28

Frage
Type IV allergic reactions are realized by means of
Antworten
  • anaphylaxis
  • complement-mediated cytolysis
  • immune reactions
  • infectious immunity

Frage 29

Frage
True hypersensitivity reactions start usually after
Antworten
  • 15-30 minutes
  • 48 hours

Frage 30

Frage
Which of the following characteristics does not belong to the Burkit lymphoma?
Antworten
  • T-cell neoplasma
  • Is a non-hodgkin lymphoma
  • Has a connections with EBV
  • Is a B-cell lymphoma

Frage 31

Frage
Antigen presenting cells are
Antworten
  • Dendrite cells and macrophages
  • T-lymphocytes
  • B-lymphocytes
  • Polymorphy-nuclear cells

Frage 32

Frage
We could use the mantoux test in diagnosis of (point two diseases) a- [blank_start]Tuberculosis[blank_end] b- [blank_start]Leprosy[blank_end]
Antworten
  • Tuberculosis
  • Leprosy

Frage 33

Frage
Which of the following factors belong to the innate immunity?
Antworten
  • Phagocytosis
  • T-lymphocytes
  • Complement, mucin, a-and b inferferons
  • Antibodies
  • Skin, mucus, normal flora
  • B-lymphocytes

Frage 34

Frage
What we could use as a subsrrate for detection of antinuclear antibodies throguh IFA?
Antworten
  • rat liver
  • rat kidney
  • rat stomach
  • hep2 cell line

Frage 35

Frage
Which of the pointed immunological parameters is most important for detection of multiple myleoma?
Antworten
  • NBT test
  • Anti-DNA antibodies
  • CD4/CD8 index
  • The Bence-jones protein

Frage 36

Frage
The most popular techniques for detection of antinuclear antibodies are
Antworten
  • Agglutination
  • Indirect immunofluorescence
  • Neutralization test
  • The complement fixation test
  • ELISA
  • Direct immunofluorescence

Frage 37

Frage
CD3 molecule is a marker for
Antworten
  • NK cells
  • Macrophages
  • Immunocompetent T lymphocytes
  • Mature B-lymphocytes

Frage 38

Frage
The accelerated reaction for rejection of transplantant is revealed
Antworten
  • Intra-operative or immediately after operation
  • 24-to 72 hours after transplantation
  • Till the third month
  • 3 month after the transplantation

Frage 39

Frage
which of the following immunological indexes ids the most important for patients with chronic granulomatous disease?
Antworten
  • NBT test
  • Anti DNA antibodies
  • CD4/CD8 index
  • The Bence-jones protein

Frage 40

Frage
CEA is increased in case of
Antworten
  • nasopharyngeal carcinoma
  • the Burkit lymphoma
  • gatro-intestinal tumors
  • smokers

Frage 41

Frage
Which of the following is connected with damage of humoral immunity?
Antworten
  • Di-George sydrome
  • Agamaglobulinemia of Bruton
  • Chronic candidosis of skin and mucus
  • Angioedema hereditaria

Frage 42

Frage
How many are complement activating ways?
Antworten
  • one
  • three
  • two
  • four

Frage 43

Frage
The complement activation occurs via three pathways which are: 1. [blank_start]Classical[blank_end] pathway 2. [blank_start]Alternative[blank_end] pathway 3. [blank_start]Lectin[blank_end] pathway
Antworten
  • Classical
  • Alternative
  • Lectin

Frage 44

Frage
The “respiratory burst" is related to
Antworten
  • Humoral immunity
  • Cellular immunity
  • Phagocytosis
  • NK-cells function

Frage 45

Frage
The immune competence of T-lymphocytes is acquired in
Antworten
  • Thyroidea
  • Bone marrow
  • Thymus
  • MALT

Frage 46

Frage
What expresses the CD8 molecule?
Antworten
  • Macrophages
  • Antigen presenting cells
  • Cytotoxic T-lymphocytes
  • T- suppressors

Frage 47

Frage
What is human cell receptor for human immunodeficiency virus (HIV)?
Antworten
  • CD3 molecule
  • CD8 molecule
  • CD4 molecule
  • CD19 molecule

Frage 48

Frage
Point the WRONG answer: Gamma interteron is produced by:
Antworten
  • Non-activated macrophages and mastocytes
  • Leucocytes and Fibroblasts
  • Activated macrophages and NK cell
  • Lymphocytes

Frage 49

Frage
The determination of functional activity of the complement might be done by
Antworten
  • Immune histochemical methods
  • Reaction neutratisation
  • CH50 test
  • Micro haemagglutination

Frage 50

Frage
CD4 molecule is situated on the surface of the
Antworten
  • Monocytes
  • T-helpers
  • Cytotoxic T-lymphocytes
  • Plasmocytes

Frage 51

Frage
The presence of the antigen together with the MHC-II class molecules is realized by
Antworten
  • Dendrite cells and macrophages
  • Cytotoxic T-lymphocytes
  • B-lymphocytes
  • Plasmocytes

Frage 52

Frage
A B-cell can synthesise some different antibodies with different species of the antigen
Antworten
  • True
  • False

Frage 53

Frage
After the antigen stimulus the mature B-lymphocytes are transformed into
Antworten
  • cytotoxic cell
  • immunocompetent cell
  • plasmocyte

Frage 54

Frage
What tests are for evaluation of the phagocytic activity?
Antworten
  • Flow cytometry of detection of oxidative burst
  • Serum levels of immunoglobulins
  • CD4/CD8 index
  • NBT test

Frage 55

Frage
Paraproteinemias are detected in
Antworten
  • Multiple myeloma
  • Reiter's Syndrome
  • Waldenstrom macroglobulinemia
  • Chronic lymphoid leukemia
  • SLE

Frage 56

Frage
Last cells, incapable to divide are
Antworten
  • Plasmocytes
  • Neutrophils
  • T-lymphocytes
  • B-Iymphocytes

Frage 57

Frage
What do the mature B-lymphocytes express on their surface?
Antworten
  • lgM and IgD
  • IgD ant IgE
  • IgM and IgA
  • IgG and IgD

Frage 58

Frage
How do CD8 eliminate their targets?
Antworten
  • after recognition of antigen, connected with MCH-I class molecule
  • after recognition of antigen connected with MCH-II class molecule
  • via activation of an alternative way of complement
  • due releasing of interferon
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