Frage 1
Frage
Which of the following is not a pattern of cell death in tissues?
Antworten
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fibrinoid necrosis
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fat necrosis
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coagulative necrosis
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contracture necrosis
Frage 2
Frage
Compare acute cell injury with cellular adaptations.
Antworten
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Cellular adaptations develop over a brief period of time and are reversible
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Acute cell injury can be manifested as reversible cell swelling
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Acute cell injury can be manifested as irreversible necrosis
Frage 3
Frage
What is lipofuscin?
Antworten
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Blue-pigmented cytoplasmic inclusions in stressed cells
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A lipid-containing residual body of autophagy
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An irreversible "wear and tear" pigment
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A product of cells undergoing decreased cell turnover
Frage 4
Frage
Metatstatic calcification is due to precipitation of calcium at sites of cell/tissue injury
Frage 5
Frage
Which of the following mechanisms explains the pathogenesis of alcohol-induced fatty liver?
Antworten
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Increased delivery of free fatty acids
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Increased lipogenesis
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Decreased apoprotein synthesis for triglyceride export
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Increased utilization of triglycerides and oxidation of fatty acids
Frage 6
Frage
Metaplasia can be characterized by which of the following?
Antworten
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One adult cell type being replaced by another through chronic injury
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Irreversible change in cells/tissue
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Decreased risk of malignancy/neoplasia
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Increase in cell number
Frage 7
Frage
Which is an example of physiologic apoptosis?
Frage 8
Frage
Apoptosis can result from endogenous OR exogenous causes
Frage 9
Frage
In a Masson Trichrome stain
Antworten
-
Nucleic acids stain dark blue
-
Connective tissue stains blue
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Proteins stain light purple
Frage 10
Frage
Which of the following would you expect to see in necrosis?
Antworten
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A rounded up, fragmented cell morphology
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Phagocytosis by neutrophils
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Phagocytosis by macrophages and nonprofessional macrophages
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Functionally intact cell membrane
Frage 11
Frage
You are examining the tissue of a patient who had a subarachnoid hemorrhage. When looking at the brain tissue microscopically, what would you expect to observe in the area of hemorrhage?
Frage 12
Frage
At what point in cell injury would you expect to observe hydropic change of the cell?
Antworten
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< 10 minutes
-
10-15 minutes
-
15-60 minutes
-
4-8 hours
Frage 13
Frage
You know that irreversible cell injury is often characterized by nuclear changes. Which of the nuclear changes describes pyknosis?
Antworten
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Fragmentation of the nucleus into dense basophilic fragments ("nuclear debris")
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Dissolution of nuclear fragments
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Condensation of chromatin
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Dilation of the endoplasmic reticulum
Frage 14
Frage
In coagulative necrosis, the shapes of cells and tissues change dramatically, but the nuclei/organelles are intact.
Frage 15
Frage
Where would you expect to see liquefactive necrosis most often?
Antworten
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Brain
-
Lungs
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Abscesses
-
GI tract
Frage 16
Frage
Your patient's cells and tissues demonstrate obvious enzymatic necrosis. You immediately know the condition that (likely) caused this is:
Antworten
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COVID
-
Acute pancreatitis
-
Myocardial infarction
-
Hypercalcemia
Frage 17
Frage
What is the most common cause of caseous necrosis?
Frage 18
Frage
Fibrinoid necrosis is caused by injury to vessel walls that causes leakage of protein and fibrin from the circulation that becomes entrapped. Which vascular injury might cause this type of necrosis?
Frage 19
Frage
What is a heterophagosome?
Antworten
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A secondary lysosome involved in digestion of a cell's own organelles
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A primary lysosome fused with absorptive vesicles originating from the plasma membrane
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A small vesicle budding from enzymes on the lateral side of the Golgi apparatus
Frage 20
Frage
In your elective oncology rotation, a patient presents with multiple calcified breast tumors. You know this to be a result of metastatic calcification.
Frage 21
Frage
Upon histological examination, tissue cells demonstrate what looks like "nuclear dust". This is characteristic of
Antworten
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karyorrhexis
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karyolysis
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karyogram
-
pyknosis
Frage 22
Frage
In response to [blank_start]cigarette smoke[blank_end], columnar epithelial cells of the bronchial epithelium undergo squamous [blank_start]metaplasia[blank_end]. Smoking-induced metaplasia may lead to bronchial squamous cell [blank_start]neoplasia[blank_end].
Antworten
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cigarette smoke
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sitting for 12 hours/day
-
drinking too much water
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pulmonary HTN
-
metaplasia
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hyperplasia
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neoplasia