2687344
Frage 1
Frage
Parenteral administration of drugs describes what?
Antworten
-
Orally/Rectally
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Intravenously/Intramuscularly
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Inhaled
Frage 2
Frage
Percutaneous administration of drugs describes what?
Antworten
-
Inhaled
-
Orally/Rectally
-
Intravenously/Intramuscularly
Frage 3
Frage
Enteral administration of drugs describes what?
Antworten
-
Orally/Rectally
-
Intravenously/Intramuscularly
-
Inhaled
Frage 4
Frage
What is an advantage of the parenteral route of administration?
Antworten
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Easy to administer on unconscious patients
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Reaches the blood stream first and avoids first pass metabolism
Frage 5
Frage
What is an advantage of percutaneous administration of drugs?
Antworten
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Easy to administer on unconscious patients
-
Reaches the blood stream first and avoids first pass metabolism
Frage 6
Frage
Repeated doses of general anaesthetic such as thiopental can cause a fatal dose because of accumulation, or "tissue binding" in adipose tissue.
Antworten
- True
- False
Frage 7
Frage
1st pass metabolism describes what phenomenon?
Antworten
-
When the concentration of a drug available to the systemic circulation (it's bioavailability) is significantly reduced because it is metabolised by the liver before it reaches the systemic circulation.
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When the concentration of a drug available to the systemic circulation (it's bioavailability) is significantly increased because it is metabolised by the liver before it reaches the systemic circulation.
Frage 8
Frage
1st pass metabolism can be useful for activating pre-cursor drugs such as L-dopa into dopamine.
Antworten
- True
- False
Frage 9
Frage
Steady state in pharmacology describes what?
Antworten
-
Drug absorption = Drug elimination
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Drug absorption > Drug elimination
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Drug absorption < Drug elimination
Frage 10
Frage
What is the plasma half life of a drug?
Antworten
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The time for half of the drug to be eliminated from the blood
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The time it takes for a drug to lose half of its pharmacological activity
Frage 11
Frage
What is meant by the hydrophobic effect?
Antworten
-
Amino acids with non-polar (hydrophobic) groups arrange themselves on the inside of a protein and vice versa.
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Amino acids with non-polar (hydrophilic) groups arrange themselves on the inside of a protein and vice versa.
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Amino acids with polar (hydrophobic) groups arrange themselves on the inside of a protein and vice versa.
-
Amino acids with polar (hydrophilic) groups arrange themselves on the inside of a protein and vice versa.
Frage 12
Frage
Haemoglobin in sickle cell is dysfunctional as a result of an incorrect hydrophobic effect.
Antworten
- True
- False
Frage 13
Frage
What is the primary structure of a protein?
Antworten
-
Sequence of amino acids
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Folding into an alpha helix or beta pleated sheet
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Folding of a polypeptide chain and addition of prosthetic groups
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Many polypeptide chains
Frage 14
Frage
What is the secondary structure of a protein?
Antworten
-
Sequence of amino acids
-
Folding into an alpha helix or beta pleated sheet
-
Folding of a polypeptide chain and addition of prosthetic groups
-
Many polypeptide chains
Frage 15
Frage
What is the tertiary structure of a protein?
Antworten
-
Sequence of amino acids
-
Folding into an alpha helix or beta pleated sheet
-
Folding of a polypeptide chain and addition of prosthetic groups
-
Many polypeptide chains
Frage 16
Frage
What is the quaternary structure of a protein?
Antworten
-
Sequence of amino acids
-
Folding into an alpha helix or beta pleated sheet
-
Folding of a polypeptide chain and addition of prosthetic groups
-
Many polypeptide chains
Frage 17
Frage
The two weakly ionising groups of an amino acid are?
Antworten
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Amino group
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Carboxyl group
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R group
Frage 18
Frage
With a pKa value of 9.7, and the equation NH3+ -> NH2 + H+ , at pH 9 what species will dominate?
Antworten
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NH2 + H+
-
NH3+
Frage 19
Frage
What graph correctly depicts the dose response curve?
Antworten
Frage 20
Frage
Response is proportional to occupancy
Antworten
- True
- False
Frage 21
Frage
The maximum response cannot be attained when a competitive reversible antagonist is present.
Antworten
- True
- False
Frage 22
Frage
In the presence of a competitive reversible antagonist, how is the dose response curve shifted?
Antworten
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Left
-
Right
Frage 23
Frage
An irreversible antagonist means that the maximum response can never be reached.
Antworten
- True
- False
Frage 24
Frage
How is the dose response curve shifted in the presence of an irreversible antagonist?
Antworten
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Down
-
Up
Frage 25
Frage
Irreversible antagonists cause a decrease in the maximal response when spare receptors are not present.
Antworten
- True
- False
Frage 26
Frage
Prolonged exposure to a drug reduces the bodies response to it.
Antworten
- True
- False
Frage 27
Frage
Without spare receptors, non-competitive antagonists can reduce the maximal response (Emax).
Antworten
- True
- False
Frage 28
Frage
When a non-competitive antagonist is used in the presence of spare receptors, the dose response curve shifts left.
Antworten
- True
- False
Frage 29
Frage
Non-competitive antagonists do not compete for the agonist binding site.
Antworten
- True
- False
Frage 30
Frage
Irreversible antagonists reduce the number of available receptors.
Antworten
- True
- False
Frage 31
Frage
The dose response curve of an irreversible agonist is shifted down because the maximal response is decreased.
Antworten
- True
- False
Frage 32
Frage
Select common ways that cells regulate their functions via receptors
Antworten
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Altering membrane potential
-
Phosphorylating enzymes
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Altered gene expression in cells
Frage 33
Frage
An integral tyrosine kinase can be activated and then phosphorylates a target molecule such as an enzyme.
Antworten
- True
- False
Frage 34
Frage
Lipophobic molecules can cross the PM and NM and bind to steroid receptors e.g. to boost transcription.
Antworten
- True
- False
Frage 35
Frage
G-protein coupled receptors have ATPase activity that turns their activity off.
Antworten
- True
- False
Frage 36
Frage
Cytokine receptors activate JAK that can phosphorylate targets and lead to signal pathways.
Antworten
- True
- False
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