Glycogen Phosphorylase

Beschreibung

Year 2 (Insulin & Glucagon) Quiz am Glycogen Phosphorylase, erstellt von gina_evans0312 am 23/10/2013.
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Quiz von gina_evans0312, aktualisiert more than 1 year ago
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Erstellt von gina_evans0312 vor etwa 11 Jahre
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Zusammenfassung der Ressource

Frage 1

Frage
Which form of Glycogen Phosphorylase is relatively inactive?
Antworten
  • Phosphorylase A
  • Phosphorylase B

Frage 2

Frage
In phosphorylase B, where is the N terminus?
Antworten
  • Floating free in the cytoplasm
  • Attached to the protein body
  • Unattached from protein

Frage 3

Frage
Which of the forms of glyocgen phosphorylase is most effected by cellular AMP/ATP levels?
Antworten
  • Phosphorylase A
  • Phosphorylase B

Frage 4

Frage
Which of the following phosphorylates Glycogen Phosphorylase?
Antworten
  • Phosphorylase B Kinase
  • Phosphorylase A Kinase
  • Phosphorylase Kinase

Frage 5

Frage
What protein causes the dephosphorylation of phosphorylase?
Antworten
  • Protein phosphatase
  • Protein phosphorylase
  • Prokein Kinase P

Frage 6

Frage
What is needed for the reaction of Phosphorylase B --> A to reverse itself?
Antworten
  • Water (and a lack of inhibiting AMP)
  • Water (and a lack of inhibiting ATP)
  • Water (and a lack of inhibiting GMP)

Frage 7

Frage
What is different about Phosphorylase A to B?
Antworten
  • Ser14 has been phosphorylated
  • Tyr14 has been phosphorylated
  • Thr14 has been phosphorylated

Frage 8

Frage
What difference does phosphorylating Glycogen phosphorylase make?
Antworten
  • Makes the relaxed form much more likely
  • Makes the taut form much more likely
  • Deactivates it entirely

Frage 9

Frage
How does phosphorylase B Kinase connect Glycogen Phosphorylase levels to the level of stimulation?
Antworten
  • It is activated by Ca2+- when the muscle is stimulated, glucose is needed and so glycogen is broken down
  • It is deactivated by Ca2+- when the muscle is stimulated, glucose is not needed and so glycogen isn't broken down

Frage 10

Frage
What part of Phosphorylase B Kinase binds to Calcium?
Antworten
  • Calmodulin
  • Calsequestrin
  • Troponin C

Frage 11

Frage
Which parts of phosphorylase B kinase are regulatory?
Antworten
  • Alpha and beta
  • Alpha and gamma
  • Gamma and beta

Frage 12

Frage
Which part of phosphorylase B kinase is catalytic?
Antworten
  • Gamma
  • Delta
  • Beta

Frage 13

Frage
In phosphorylase B kinase's Ca2+ binding sites, what are the affinities?
Antworten
  • 2 high 2 low
  • 4 high
  • 4 low

Frage 14

Frage
What protein causes the phosphorylation of Phosphorylase B Kinase?
Antworten
  • cAMP dependent Protein Kinase
  • Adenylate Cyclase
  • Glycogen Phosphorylase

Frage 15

Frage
What is another name of cAMP dependent protein kinase?
Antworten
  • Protein Kinase A
  • Protein Kinase B
  • Protein Kinase C

Frage 16

Frage
What is the role of inhibitor one?
Antworten
  • To bind to protein phosphatase, activating it
  • To bind to protein phosphatase, inhibiting it
  • To bind to protein kinase A, activating it

Frage 17

Frage
What is contained in the N terminus domain of Glycogen Phosphorylase?
Antworten
  • The catalytic site
  • The allosteric effector site
  • The regulatory subunit

Frage 18

Frage
How does glycogen get from it's binding domain to the catalytic site?
Antworten
  • A hydrophobic tunnel
  • A hydrophillic tunnel
  • A lipophobic tunnel

Frage 19

Frage
Why is glycogen phosphorylase's site in a deep groove?
Antworten
  • To prevent AMP from entering
  • To prevent ATP from entering
  • To prevent water from entering

Frage 20

Frage
What happens if water enters the active site?
Antworten
  • Nothing
  • The enzyme is deactivated
  • Hydrolysis occurs instead of phosphorolysis
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