39211836
Beschreibung
Quiz von Leon Schwarze, aktualisiert vor 6 Monate
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Erstellt von Leon Schwarze
vor 6 Monate
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Frage 1
Frage
Definition KPC
Klebsiella Pneumoniae carbapenemase
Antworten
- True
- False
Frage 2
Frage
Beta-lactams don’t work on atypical bacteria, because:
Atypical bacteria lack cell walls and thus are naturally resistant against all beta-lactams
&
because beta-lactams act by preventing the synthesis of the bacterial cell wall.
Antworten
- True
- False
Frage 3
Frage
Which bacteriaare intrinsically resistant to vancomycin (glycopeptide)
Antworten
-
a) Lactobacillus
-
b) Erysipelothrix
-
c) a+b
Frage 4
Frage
Resistance to [blank_start]Quinolones[blank_end]. is caused by chromosomal mutation in structural genes of DNA gyrase and topoisomerase IV
Antworten
-
Quinolones
Frage 5
Frage
Which Bacteria can become resistant to Macrolides
Antworten
-
Staphylococcus
-
Streptococcus
Frage 6
Frage
In gentamicin active efflux of drug in bactericides
Antworten
- True
- False
Frage 7
Frage
Chloramphenicol is the enzymatic modifcation of acetyltransferase-
Antworten
- True
- False
Frage 8
Frage
Which resistant bacterias are enzymatic
Antworten
-
PRSA
-
HLAR
-
MRSA
-
ESBL
-
KPC
Frage 9
Frage
Resistant bacterias witch are NOT enzymatic but have an altered target site
Antworten
-
MLSb
-
PRSP
-
MBL
-
MRSA
-
VRE
Frage 10
Frage
MRSA ?
[blank_start]methicillin[blank_end] [blank_start]resistant[blank_end] [blank_start]staphylococcus[blank_end] [blank_start]aureus[blank_end]
resistant against all beta-lactams and inhibitors, excluding 5th generation of cephalosporins
Antworten
-
methicillin
-
resistant
-
staphylococcus
-
aureus
Frage 11
Frage
Which Bacteria are resistant against Beta Lactams
Antworten
-
MBL - Metallobetalactamases
-
KPC - Klebisella pneumonia carbapanemase / CPE - Carbapanemase producing Enterobacteriaceae
-
MRSA (with exception to 5th gen cephalosporin)
-
Mycoplasma and Chlamydia
-
Chlamydia + VRE - Vancomyocinr resistant enterococcus
Frage 12
Frage
Which of the following phenotypes relate to the enzyme production
Antworten
-
VRE
-
ESBL - positive
-
HLAR
-
PRSP
-
MBL - positive
-
NDM - positive
Frage 13
Frage
Which of the following phenotypes relate to the enzyme production
Antworten
-
VRE
-
ESBL
-
HLAR
-
PRSP
-
MBL
-
Ch-
Frage 14
Frage
[blank_start]PRSP[blank_end]: Resistant to narrow penicillin & possibly 3rd gen cephalosporin
Antworten
-
PRSP
-
MRSA
-
HLAR
Frage 15
Frage
Which Bacteria are resistant to narrow penicillin
Antworten
-
a) E.coli
-
b) PRSP
-
c) MRSA
-
d) b+c
-
e) All of the mentionend
Frage 16
Frage
Which of the following may become resistent (aquired) to tigecycline
1) E.coli
2) P.aeruginosa
3) Acinetobacter baumannii
4) proteus mirabilis
5) K. pneumoniae
Antworten
-
a) 1,2,3,5
-
b) 1,3,5
-
c) 2,3
-
d) 3,4
-
e) 4,5
Frage 17
Frage
Modification of an existing PBP´s through recombination indicates
Antworten
-
a) MRSA
-
b) VRE
-
c) NDM+
-
d) PRSP
-
e) PRSA
Frage 18
Frage
Which phenotype refers to MSSA
Antworten
-
a) resistant to all beta-lactams excluding Vth generation of cephalosporin
-
b) resistant to all beta lactams including Vth generation of cephalosporin
-
c) resistant to methicillin, susceptible to oxacillin and carbapenems
-
d) susceptible to all beta lactams, excluding narrow spectrum penicillins
-
e) susceptible to all beta lactams including narrow spectrum penicillins
Frage 19
Frage
Which of the drugs are pumped out by efflux
Antworten
-
a) Tetrayclines
-
b) Vancomycin
-
c) Tigecycline
-
d) a+c
-
e) all of the mentionend
Frage 20
Frage
Choose correct Statement
Antworten
-
The class C beta-lactamases are primarily cephalosporinases and are encoded on bacterial chromosomes
-
Class B carbapenemases are i.A. New Delhi metallo-beta-lactamases
-
Colistin binds to the membrane instead of penetrating it
-
Tigecycline may be affected by efflux or enzymatic modification
-
Active efflux of gentamycin is commonly observed in Bacteroides fragilis
Frage 21
Frage
Which of the following phenotypes relate to the enzyme production:
1. VRE
2. ESBL-positive
3. HLAR
4. PRSP
5. MBL-positive
6. NDM-positive
Antworten
-
a) 1,2,3,5
-
b) 2,4
-
c) 2,5
-
d) Only 4
-
e) 2,3,5,6
Frage 22
Frage
What is an “intrinsic resistance”
[blank_start]Natural resistance[blank_end]
definition they want us to write:
Bacteria is born with such a resistance, “comes into the world”
Antworten
-
Natural resistance
Frage 23
Frage
Explain the abbreviation “NDM”: [blank_start]New Delhi[blank_end] [blank_start]Metallo-beta lactamase[blank_end]
Antworten
-
New Delhi
-
Metallo-beta lactamase
Frage 24
Frage
Resistance to this drug results from [blank_start]acetyltransferase[blank_end] which catalyzes its acetylation. This characteristic indicates:
Chloramphenicol
Antworten
-
acetyltransferase
Frage 25
Frage
Class B ß-Lactamases:
Antworten
-
a.) Are Zinc dependent Metalloenzymes
-
b.) Have Broad spectrum of action
-
c.) SHV-1 and TEM-1 are Major examples
-
d.) a+b
-
e.) None of the above
Frage 26
Frage
Tetracycline resistance develops with which of the following mechanisms?
Antworten
-
a) Decreased penetration into the bacterial cell
-
b) Active efflux of the drug
-
c) Alteration of the ribosomal target site
-
d) a+c
-
e) all of the above
Frage 27
Frage
Natural resistance is observed in:
Antworten
-
a) Pediococcus, Leuconostonc, Erysipelothrix, Lactobacillus
-
b) E.Coli, Klebsilla
-
c) Staphylococci
-
d) a+b
-
e) none of the above
Frage 28
Frage
Pseudomonoas aeruginosa is intrinsically resistant to:
Antworten
-
a) Tigecycline
-
b) Tobramycin
-
c) Meropenem
-
d) Ceftazidime
-
e) Sulphonamides
-
f) d+e
Frage 29
Frage
Resistance through enzymatic modification of the drug is observed in:
Antworten
-
a. Clindamycin – Str. Pyogenes
-
b. ß-Lactams – chlamydia
-
c. E. coli – glycopeptides
-
d. Isoniazid – mycobacteria
-
e. None of the above
Frage 30
Frage
Strict anaerobic bacteria have an intrinsic resistance to:
Antworten
-
d. Clindamycin
-
e. None of the above
-
c. Metronidazole
-
b. Ampicillin
-
a. Gentamicin
Frage 31
Frage
Which of the following phenotypes (resistance) matches the description for MRSA
Antworten
-
a. Penicillin G, ureidopenicillin, imipenem, vancomycin – susceptible
-
b. Vancomycin, imipenem – susceptible; penicillin, 1st and 2nd Generation cephalosporins – resistant
-
c. Vancomycin – susceptible; penicillin, Cephalosporin, carbapenem – resistant d. Penicillin – susceptible; vancomycin, carbapenem, cephalosporin – resistant
-
d) a+b
-
e) none
Frage 32
Frage
Partial modification of a PBP through recombination in:
Antworten
-
e. All of the above
-
d. Klebsiella pneumoniae
-
c. MRSA-acquisition of new pbp
-
b. Streptococcus pneumoniae
-
a. Escherichia Coli
Frage 33
Frage
Which of the following haven an aquired resistance to ß-Lactams
Antworten
-
a) MRSA
-
b) PRSP
-
c) ESBL
-
d) a+b
-
e) All of the above
Frage 34
Frage
Strict anaerobic bacteria are resistant to:
Antworten
-
a) Gentamicin
-
b) Penicillin
-
c) Metronidazole
Frage 35
Frage
Which of the following resistance phenotypes are associated with PBP modification
Antworten
-
a) NDM
-
b) ESBL
-
c) PRSP
-
d) KPC
-
e) MRSA
-
f) c+e
Frage 36
Frage
Choose true Statement
Antworten
-
a) Efflux of aminoglycosides occurs rarely in gram negative bacteria
-
b) Penicillin G is inactivated with gastric acid
-
c) Gram negative bacteria rapidly develop resistance against beta lactams by production
-
d) all of the above
Frage 37
Frage
Intrinsic Resistance to sulphonamides
Antworten
-
a) Pseudomonas aeruginosa
-
b) Nocardia
-
c) Chlamydia
-
d) B+c
Frage 38
Frage
HLAR - [blank_start]high level[blank_end] [blank_start]aminoglycoside[blank_end] [blank_start]resistance[blank_end]
Antworten
-
high level
-
aminoglycoside
-
resistance
Frage 39
Frage
MRSA - [blank_start]methicillin[blank_end] [blank_start]resistant[blank_end] [blank_start]staphylococcus[blank_end] [blank_start]aureus[blank_end]
Antworten
-
methicillin
-
resistant
-
staphylococcus
-
aureus
Frage 40
Frage
Choose true combination of drugs resistance against
Antworten
-
a) Rifampin – rna polymerase
-
b) Levofloxacin – mosaic PBP
-
c) Erythromycin – enzyme modification
-
d) Penicillin G- enzyme modification
-
e) a+c+d
Frage 41
Frage
Resistance to this drug with protein production similar to elongation factor that protects 30S ribosomal subunit indicates the resistance to?
Antworten
-
a) Penicillin
-
b) Azithromycin
-
c) Tetracyclines
-
d) Rifampin
Frage 42
Frage
Acquired resistance to penicillin G is observed in
Antworten
-
a) Streptococcus pyogenes
-
b) E.coli
-
c) Streptococcus pneumonia
-
d) a+c
Frage 43
Frage
Give two examples of mechanisms of resistance with change of target site?
Antworten
-
PRSP
-
MRSA
Frage 44
Frage
Give 2 groups of drugs that are elimanted by efflux group
Antworten
-
Quinolones
-
Tetracycline
Frage 45
Frage
Resistance to aminoglycosides
Antworten
-
Decreased permeability
-
Enzymatic modification
Frage 46
Frage
Erythomyocin is not active against K.Pneumoniae
Antworten
- True
- False
Frage 47
Frage
Which of the following resistant phenotypes are associated with aminoglycosides modyfying enzyme production
HLAR
Antworten
- True
- False
Frage 48
Frage
Choose True sentence
Antworten
-
a) Bacteria can become resistant to β-lactam antibiotics hydrolysis of the antibiotic by bacterial enzymes
-
b) Exclusion of B-lactamases in treatment of infection caused by non fermented process also due to decreased permeability of membrane
-
c) Enterobacteriaceae develop resistance to cephalosporins also due to the enzymes production
-
d) a+c
Frage 49
Frage
Intrinsic resistance to Linezolid - Escheria
Antworten
- True
- False
Frage 50
Frage
Resistance to Metronidauole due to
Antworten
-
Rescreased uptake of antibiotic
-
Elimination of cytotoxic compound before they reach DNA
Frage 51
Frage
Intrinsic resistance to Penicillin G - S pyogenes
- Chlamydia
Antworten
- True
- False
Frage 52
Frage
Pumped out by efflux pump
Antworten
-
Tetracyclines
-
Aminoglycosides
Frage 53
Frage
Which phenotype refers to MRSA?
Antworten
-
a.) resistant to all beta lactams including vth generations of cephalosporins
-
b.) resistant to all beta lactams excluding vth generations of cephalosporins
-
c.) resistant to methicillin,susceptible to oxacillin and carbapenem
-
d.) resistant to beta lactams,resistant to vancomycin,susceptible to monobactams
-
e.) none of the mentioned
Frage 54
Frage
Enterococcus gallinarum and casseliflavus are instrinctly resistant
Antworten
-
e)all mentioned
-
d.) a+c
-
c.) vancomycin contain D-alanine-D-serine terminus
-
b.)Linezolid
-
a.) Tigecycline
Frage 55
Frage
Correct Examples
Antworten
-
A class beta- lactamase = SHV-1 penicillinases found in common gram negative rods (and TEM-1)
-
B class beta - lactamase= New Delhi metallo-ß-lactamases
Frage 56
Frage
Which of the following may become resistant (acquired resistant) to macrolides
Antworten
-
S.pyogenes
-
K.pneumoniae
-
S.aureus
-
Acinetobacter baumannii
-
P.aeruginosa
-
E.coli
Frage 57
Frage
Resistance to Aminoglycosides may result from:-
Antworten
-
e.)all mentioned
-
d.)a+c
-
c.)increased expulsion of drug from cell
-
d.)decrease uptake of drug
-
a.)mutation of ribosomal target site
Frage 58
Frage
Resistance to this drug results from acetyltransferase which catalyse to acetylation:-this characteristics indicate
Antworten
-
e.)chloramphenicol
-
d.)imipenem
-
c.)penicillin G
-
b.)ceftriaxone
-
a.)Sulfamethoxazol
Frage 59
Frage
Intrinsic resistance to tigecyycline is observed in
Antworten
-
a) Morganella
-
b) Providencia Proteus and P aeruginosa
-
c) Pseudomonas
-
d) b+c
-
e) all mentioned
Frage 60
Frage
Which of the following is/are enzyme producers:
1.S.pyogenes
2.ESBL +
3.HLAR +
4.PRSP
5.MBL +
6.chlamydia trachomatis
Antworten
-
1,2,3,5
-
2,5
-
2,3,5
-
only 4
-
2,3,5,6
Frage 61
Frage
Becomes resistant to aztreonam
Antworten
-
e. faecalis
-
p.aeruginosa
-
acinobacter baumanii
-
s.aureus
-
s epidermidis
-
s pygones
Frage 62
Frage
1. Complete information regarding the 3 ways how bacteria can become resistant to beta-lactam antibiotics:
Antworten
-
Decreased concentration of antibiotic at the cell wall from target site
-
Decreased binding of antibiotic to the PBP
-
Enzymatic modification
-
All
-
None
Frage 63
Frage
a. ESBL - [blank_start]Extended[blank_end] [blank_start]spectrum[blank_end] [blank_start]beta lactamase[blank_end]
b. VRE - [blank_start]Vancomycin[blank_end] [blank_start]resistant[blank_end] [blank_start]enterococci[blank_end]
c. KPC - [blank_start]Klebsiella[blank_end] [blank_start]Pneumoniae[blank_end] [blank_start]Carbapenemase[blank_end]
Antworten
-
Extended
-
spectrum
-
beta lactamase
-
Vancomycin
-
resistant
-
enterococci
-
Klebsiella
-
Pneumoniae
-
Carbapenemase
Frage 64
Frage
5. Which of the following resistance mechanism phenotypes stem from the enzymatic modification of the drug:
Antworten
-
a. PRSA
-
b. VRE
-
c. HLAR
-
d. MBL
-
e. a+c+d
Frage 65
Frage
7. Which of the following phenotype refers to MBL + P.aeruginosa:
Antworten
-
a. Susceptible to carbapenems, resistant to beta lactams and its combinations with inhibitors
-
b. resistant to all beta lactams with exclusion of its combination with inhibitors
-
c. resistant to all beta lactams with possible exception of aztreonam
-
d. resistant to all beta lactams with possible exception of monobactams
-
e. c+d
Frage 66
Frage
a. A class beta lactamases: [blank_start]KPC, SHV-1, TEM-1[blank_end]
b. B class beta lactamases: [blank_start]MBL, NDM, VIM[blank_end]
Antworten
-
KPC, SHV-1, TEM-1
-
MBL, NDM, VIM
Frage 67
Frage
Which of the following may become resistant to Rifampin?
Antworten
-
E.Coli
-
P. Aeruginosa
-
Acinebacter Baumanii
-
S. Auereus
-
S. Pneumonia
-
M. Tuberculosis
Frage 68
Frage
10. which of the following may become resistant (acquire resistance) to rifampin:
(1) E.coli
(2) P. aeurigonase
(3) acinetobacter baumanii
(4) S .aureus
(5) K .pneumonia
(6) M. tuberculosis
Antworten
-
1,2,3,5,6
-
4,3,5
-
4,5,6
-
2,3
-
4,6
Frage 69
Frage
Choose Correct Statement
Antworten
-
1. Resistance to amikacin can stem from decreased uptake of drug into bacterial cell
-
2. Bacteroides fragilis is intrinsically resistant to metronidazole
-
3. Most of gram (+) bacteria is resistant to macrolides
Frage 70
Frage
Which of the follwoing resistance phenotypes refers to MBL P+Aeruginosa
Antworten
-
1. Susceptible to carbapenems, resistant to B-lactams and its combinations
-
2. Resistant to all B-lactams, with exclusion of its combination with inhibitors
-
3. Resistant to all B-lactams, with possible exception of azteonem
-
4. Resistant to all B-lactams, with possible exception of macrolides
Frage 71
Frage
Complete information regarding the ways how bacteria can become resistant to aminoglycosides:
Antworten
-
Target site modification
-
Decreased membrane permeability
-
Active efflux
-
: Enzymatic inactivation of antimicrobial agent
Frage 72
Frage
Choose Correct Statement
Antworten
-
a/ Pseudomonas aeruginosa is intrinsically resistant to trimethoprim.
-
b/ Overexpression of efflux pumps determines the resistance to ciprofloxacin
-
c/ Polymyxins are not effective against Gram-positive bacteria due to the lack of outer membrane in these.
Frage 73
Frage
Explain the abbreviations:
PRSP: [blank_start]Penicillin resistant[blank_end] [blank_start]streptococcus pneumoniae[blank_end]
HLAR: [blank_start]High level[blank_end] [blank_start]aminoglycoside[blank_end] [blank_start]resistance[blank_end]
NDM: [blank_start]New delhi[blank_end] [blank_start]metallo-beta-lactamase[blank_end]
Antworten
-
Penicillin resistant
-
streptococcus pneumoniae
-
High level
-
aminoglycoside
-
resistance
-
New delhi
-
metallo-beta-lactamase
Frage 74
Frage
Intrinsic resistance to glycopeptides is observed in:
Antworten
-
a/ Lactobacillus
-
b/ Streptococcus pneumoniae
-
c/Enterococci
-
d/ E coli
-
e/ a+d
Frage 75
Frage
Which of the following resistance phenotype refers to MRSA:
Antworten
-
a/ Resistant to beta-lactams with possible exception of its combinations with inhibitors.
-
b/ Resistant to all beta-lactams, susceptible to Vth generation of cephalosporins
-
c/ Resistant to narrow spectrum penicillins, resistant to macrolides and lincosamides.
-
d/ Resistant to all beta-lactams, with possible exception of monobactams.
-
e/ c+d
Frage 76
Frage
Resistance to gentamicin in Bacteroides fragilis is due to...[blank_start].lack of aerobic metabolism[blank_end]
Antworten
-
.lack of aerobic metabolism
Frage 77
Frage
Which of the following may become resistant (acquire resistance) to tigecycline:
Antworten
-
1. Proteus mirabilis
-
2. P. aeruginosa
-
3. Morganella morganii
-
4. E. faecalis
-
5. K. pneumoniae
-
6. Providencia retgerii
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