LESSON 26 & 27

In the mitochondrial matrix

In the mitochondrial membrane

In the cytosol

In the reticulum endoplasmatic

Any of these

AcetylCoA is produced in mitochondria and can not get out by itself

AcetylCoA reacts with oxaloacetate forming citrate

In the cytosol, citrate is going to be transformed into AcetylCoA and oxaloacetate with an enzyme called citrate lyase

Oxaloacetate need to go back to mitochondria and then can participate in lipolysis

The tissues where the biosynthesis of Fatty acids takes place are liver, adipose tissue and mammary gland

Citrate lyase

AcetylCoA carboxylase

Fatty acid synthase

Acyl protein carrierase

ACP transferase

AcetylCoA carboxylase will be active as a polymer

Acetyl carboxylase will form a polymer in presence of citrate

Acetyl carboxylase will be inactive in presence of Palmitic acid

AcetylCoA carboxylase is active when it is phosphorylated

In a fed state, acetyl CoA will be active and we will produce MalonylCoA

Acyl carrier protein has two different SH groups

One molecule of AcetylCoA will bind to the enzyme fatty acid synthase

One molecule of MalonylCoA will bind to the Acyl carrier protein

During the biosynthesis de novo, when a condensation is produce we obtain one molecule of CO2 and a fatty acid with a double bond between α-Carbon and ß-Carbon

During the biosynthesis de novo, a translocation of the fatty acid from ACP to the FAD is produced and the process repeats again

In the condensation

In the dehydration

In the reduction

In the elongation

Any of these

When we obtain a fatty acid with 18C atoms (Palmitic acid)

When we obtain a fatty acid with 16C atoms (Palmitic acid)

When we obtain linoleate

When we obtain α-linoleate

When a double bound in a position higher than 9 is produced

If the phosphoglyceride does not have Nitrogen, phosphatidic acid is going to react with CTP obtaining CDP-DAG

If the phosphoglyceride does not have Nitrogen, phosphatidic acid will be transformed to diacylglycerol

If the phosphoglyceride does not have Nitrogen, phosphatidic acid is going to react with CTP obtaining diacylglycerol

If the phosphoglyceride does not have Nitrogen, phosphatidic acid will be transformed to diacylglycerol and then is going to react with CTP obtaining CDP-DAG

The combination of the non-polar molecule activated will react forming the phosphoglyceride