Chromosomal Abberations and Repair

Beschreibung

Year 2 Quiz am Chromosomal Abberations and Repair, erstellt von gina_evans0312 am 17/12/2013.
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Zusammenfassung der Ressource

Frage 1

Frage
Which of the following can cause double strand breaks in the DNA?
Antworten
  • Ionising radiation
  • Meiosis
  • Chemicals
  • DNA replication errors

Frage 2

Frage
What are Chromosome Fragile Sites?
Antworten
  • Sites where double strand breaks are likely to occur
  • Sites that can be easily split accidentally by protein machinery
  • Sites that are likely to warp during heat shock

Frage 3

Frage
Chromosome fragile sites are thought to be caused by difficulties during meiosis
Antworten
  • True
  • False

Frage 4

Frage
What does NHEJ stand for?
Antworten
  • Non-homologous end joining
  • Non-homologous editing joints
  • Non-heterodimeric end joints

Frage 5

Frage
What are the requirements for NHEJ?
Antworten
  • Double strand breaks
  • Single strand breaks
  • T-T lesions
  • DNA ligase 4
  • DNA ligase 2

Frage 6

Frage
The repair process of NHEJ will join any 2 free ends together, regardless of homology
Antworten
  • True
  • False

Frage 7

Frage
An error in NHEJ can lead to translocation between which chromosomes, forming what type of chromosome fusion?
Antworten
  • Philadelphia chromosome
  • Inverted chromosome
  • 8 &12
  • 9 & 22
  • 13 & 21

Frage 8

Frage
The repair process of Homologous Recombination relies on what?
Antworten
  • That the damaged sequence in the sister chromatid is intact
  • That the damaged sequence in the homologous chromosome is intact
  • That the damaged sequence in the other allele is intact

Frage 9

Frage
What is required for an error in Homologous Recombination?
Antworten
  • A faulty alignment of the two chromosomes
  • A faulty alignment of the two chromatids
  • Due to inversions
  • Due to translocations
  • Due to repeats

Frage 10

Frage
What type of repair is the image showing?
Antworten
  • NHEJ
  • Homologous Recombination

Frage 11

Frage
A fault in Homologus Recombination can lead to alleles being lost
Antworten
  • True
  • False
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