Frage 1
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Why is human african tropanomosis so common?
Antworten
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Most drugs are outdated
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Most drugs have severe side effects
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Most drugs are incredibly expensive
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Most drugs cannot be used on the immunocompromised
Frage 2
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The cause of Human African Tropanomosis is a virus known as Tropanosome
Frage 3
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Tropanosomes contain 1 mitochondria that depends on what for energy?
Antworten
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Glycerol-3-Dehydrogenase
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Succinate Dehydrogenase
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NADH Dehydrogenase
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Malate Dehydrogenase
Frage 4
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The enzyme that tropanosomes rely on allows glycolysis to continue indefinitely
Frage 5
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What other components make up the tropanonsome's mitochondria?
Antworten
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Alternative Oxidase
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Quinol
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Cytochrome C
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Cytochrome BC1 complex
Frage 6
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How does Alternative Oxidase get its energy source?
Antworten
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Glucose in the blood plasma
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Glucose in the infected red blood cell
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Glucose from other blood proteins
Frage 7
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Cryptosporidium Parvum can only become fatal to the immunocompromised
Frage 8
Antworten
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Cryptosporidium parvum cysts
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Cryptosporidium parvum oocysts
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Cryptosporidium parvum oocytes
Frage 9
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Which of the following are characteristic of Alternative Oxidase?
Frage 10
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Alt. Ox. is a 34kDa monomer
Frage 11
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Why does Alt. Ox. not absorb above 340nm?
Antworten
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It contains no Cyt's or Fe-S
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It contains no chromosomes
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It contains no Cty's or Flavins
Frage 12
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To activate, Alt. Ox must form a dimer
Frage 13
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What is particular about Rubreythrin?
Antworten
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It is the olden protein yet sequenced - 4 billion years old
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It's the smallest protein yet sequenced - just 40 aa long
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It's the largest protein yet sequenced - 400,000 kDa
Frage 14
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Only 6 aa in Alt. Ox have been conserved, relating it to other di-iron proteins
Frage 15
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The conserved sequence of Alt. Ox. codes for amino acids holding what?
Antworten
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Iron
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Magnesium
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Copper
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Sodium
Frage 16
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Which of the following list characteristics of Alt. Oxidase?
Antworten
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Sits horizontally in the membrane
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Sits vertically in the membrane
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Made of 2 chains, almost entirely of alpha helices
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Made of 3 chains, almost entirely of alpha helices
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Made of 2 chains, almost entirely of beta sheets
Frage 17
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2 Alpha helices dock Alt. Ox in the membrane
Frage 18
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How does the substrate get to Alt. Ox's active site?
Antworten
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Through a hydrophobic cavity
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It is 'caught' by alpha helices extending into the cytoplasm
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It uses membrane phospholipids which move through it
Frage 19
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The following shows the core of Alt. Oxidase- what's contained in it?
Antworten
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2 Fe atoms
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2 Cu atoms
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Linked by hydroxyl groups
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Linked by amide groups
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From 4 leucine residues
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From 4 glutamine residues
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And 2 Histadine &1 Tyrosine residues
Frage 20
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The Histadine/Tyrosine residues can be used to inhibit Alt. Ox
Frage 21
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To travel through the channel and reach the active site, inhibitors must be...
Frage 22
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Different co-ordinations of the aa in the Alt. Ox core can alter the function of it
Frage 23
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Alt. Ox. is a terminal respiratory chain oxidase
Frage 24
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Where is Alt. Ox found, in infected humans?
Antworten
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Between Complexes 1 & 2
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Between complexes 2 & 3
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Between complexes 3 & 4
Frage 25
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Alternative Ox is used as a stress protein in pathogens, and an oxygen scavenger in plants
Frage 26
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Which of the following use Alt. Ox?