515453
Beschreibung
Quiz von gina_evans0312, aktualisiert more than 1 year ago
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Erstellt von gina_evans0312
vor fast 11 Jahre
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Frage 1
Frage
Why are some NSAIDs known as 'Traditional'?
Antworten
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They only block one COX
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The block both COXs
Frage 2
Frage
Describe COX1
Antworten
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Constituative
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Inducible
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Membrane bound
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Cytoplasmic
Frage 3
Frage
The channels of both COX1 & COX 2 are constricted to prevent incorrect substrate binding
Antworten
- True
- False
Frage 4
Frage
Where do NSAIDs bind on COX 1?
Antworten
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Arg 120
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Arg 130
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Arg 140
Frage 5
Frage
Aspirin binds permenantly to the Ser 530 of COX1
Antworten
- True
- False
Frage 6
Frage
Why does COX2 have a much wider channel than COX 1?
Antworten
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Val533 forces the channel to be wider
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Ser533 forces the channel to be wider
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Ile533 forces the channel to be wider
Frage 7
Frage
COX2 is inducible
Antworten
- True
- False
Frage 8
Frage
The smaller channel of COX2 can be used for selective inhibition- i.e. Colecoxib
Antworten
- True
- False
Frage 9
Frage
COX2 is much less responsible for inflammation than COX1
Antworten
- True
- False
Frage 10
Frage
Why are selective COX2 inhibitors used on patients with G.I troubles?
Antworten
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They also repair mucus membranes
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They have fewer side effects
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They cannot be digested properly by healthy tracts
Frage 11
Frage
What is the most common side effect of NSAIDs?
Antworten
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GI troubles
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Renal insufficiency
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C.V disorders
Frage 12
Frage
Aspirin is the only NSAID thought not to cause cardiovascular disorders
Antworten
- True
- False
Frage 13
Frage
Name the two NSAID side effects that contribute to cardiovascular disorders
Antworten
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Inc salt and water retention
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Constant vasoconstriction effect endothelium
Frage 14
Frage
Cole/Paracoxib are traditional NSAIDs
Antworten
- True
- False
Frage 15
Frage
What is the effect of Aspirin in platelets?
Antworten
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Reduced Thromboxin A2
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Reduced Thromboxin I2
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Reduced Thromboxin E2
Frage 16
Frage
The binding of aspirin lasts for the entire life of the platelet
Antworten
- True
- False
Frage 17
Frage
To whom can Aspirin not be given?
Antworten
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Over 65s
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Pregnant women
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Children under 16
Frage 18
Frage
Paracetamol is anti-inflammatory but not antipyretic
Antworten
- True
- False
Frage 19
Frage
The action of paracetamol is unknown
Antworten
- True
- False
Frage 20
Frage
Why is paracetamol toxic to the liver in high doses?
Antworten
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Oversaturates the removal pathway
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Causing an alternative to be used
Frage 21
Frage
The alternative paracetamol removal pathway causes an increase in toxic NAPQ1
Antworten
- True
- False
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