Zusammenfassung der Ressource
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Humans cannot metabolise the cholesterol ring system
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Reverse cholesterol transport is mediated by...
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Initially, HDLs are released from the liver with Apo_, in _ form
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A1
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B100
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Pre-Beta-HDL
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Pre-Alpha-HDL
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Cholesterol Efflux Regulatory Protein is found where?
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The liver
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Vascular endothelium
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Peripheral cells
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CERP modifies the cholesterol in the pre-beta-HDL
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What does LCAT do that makes the pre-beta-HDL spherical?
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The cholesterol is reduced
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The cholesterol is esterified
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The cholesterol is oxidised
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CETP- Cholesterol Ester Transfer Protein
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CETP transfers cholesterol esters between
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The action of CETP makes the HDL smaller
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Once the HDL has been made large enough, it returns to the liver to be picked up by
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ApoE receptors
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LDL receptors
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Scavenger receptors
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The HDLs picked up transfer the cholesterol to the cell membrane
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The returned cholesterol is then excreted as
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Free sterol
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Cholesterol esters
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Bile acids
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Xanthomea- Cholesterol depoisiton in the brain