Frage 1
Frage
Which of the following statements are TRUE regarding cardiac myocytes?
Antworten
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the vast majority of intracellular proteins are fixed and carry a positive charge
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The equilibrium membrane potential for Na+ is higher than the potential for K+
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Action potentials are initiated by the opening of voltage gated Calcium channels
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The delayed opening of voltage gated sodium channels are responsible for maintaining the plateau of the action potential
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This graph is an accurate representation of the predicted membrane potential over time.
Frage 2
Frage
The Na+/K+ ATPase helps maintain the resting membrane potential of roughly -85mV in cardiac myocytes.
For each unit of ATP expended [blank_start]3[blank_end] [blank_start]Na+[blank_end] Ions are pumped out and [blank_start]2[blank_end] [blank_start]K+[blank_end] ions pumped in
Antworten
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3
-
2
-
1
-
Na+
-
K+
-
2
-
1
-
3
-
K+
-
Na+
Frage 3
Frage
During Diastole which of the following movement of ions are occurring in cardiac myocytes.
Antworten
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There is a Net Passive movement of Na+ ions into the cell
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There is a Net Passive movement of Na+ ions out of the cell
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There is a Net Passive movement of K+ ions into the cell
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There is a Net Passive movement of K+ ions out of the cell
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There is a Net Passive movement of Ca2+ ions into the cell
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There is a Net Passive movement of Ca2+ ions out of the cell
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Na+ is being actively pumped into the cell in exchange for K+ which is being pumped out
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Na+ is being actively pumped into the cell in exchange for Ca2+ which is being pumped out
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K+ is being actively pumped into the cell in exchange for Na+ which is being pumped out
-
Ca2+ is being actively pumped into the cell in exchange for Na+ which is being pumped out
Frage 4
Frage
Which of the following statements are correct?
Antworten
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At Point 1 there is a large movement of Na+ ions into the Cell
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At Point 1 Voltage Gated Sodium channels are Open
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At Point 1 Voltage Gated Potassium channels are Open
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At Point 2 Voltage Gated Potassium channels are Open
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At Point 2 Voltage Gated Sodium channels are Open
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At Point 2 the dip in membrane potential is due to efflux of Ca2+ through voltage gated channels
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Point 3 represents the plateau, which is maintained by Calcium efflux
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Point 3 represents the plateau, which is maintained by Calcium influx
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During Stage 4 passive movement of K+ though only leak channels returns the membrane potential to rest
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During Stage 4 the net movement of chloride is from the ICF to the ECF
Frage 5
Frage
Which of the following statements is FALSE regarding the refractory period of a cardiac myocyte Action Potential?
Antworten
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The Absolute refractory period is due to the rapid inactivation of Na+ channels after they open, these channels are not reactivated until membrane potential is below 65mV
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Due to the extended refractory period, cardiac muscle can not be tetanized
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Another Action Potential can not be initiated during any of the stages 1-4
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The inactivation of VO Na+ channels causes a change in the shape of the protein channel, blocking the passage of Na+ ions.
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All of the above are true
Frage 6
Frage
Fast response action potentials occur in the SA Node
Frage 7
Frage
Order the following from those most permeable to sodium and calcium, to those least permeable to sodium and calcium.
1. [blank_start]SA Node[blank_end]
2. [blank_start]AV Node[blank_end]
3. [blank_start]Bundle of His[blank_end]
4. [blank_start]Purkinje Fibres[blank_end]
Options:
Bundle of His
SA Node
Purkinje Fibres
AV Node
Antworten
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SA Node
-
AV Node
-
Bundle of His
-
Purkinje Fibres
Frage 8
Frage
Which of the following are true of pacemaker cells in the AV Node
Antworten
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Resting Membrane potential is stable
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Resting Membrane potential is unstable
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Voltage Gated Sodium Channels are present
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Voltage Gated Calcium Channels are present
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Threshold is higher compared to Cardiac Myocytes
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Threshold is lower compared to Cardiac Myocytes
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Amplitude of the Action Potential is higher compared to Cardiac Myocytes
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Amplitude of the Action Potential is lower compared to Cardiac Myocytes
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Sodium Influx into the cell does not occur at any point in time
-
There is a greater permeability to Calcium than the SA Node
Frage 9
Frage
Parasympathetic/Vagal Innervation of the SA Node will result in
Antworten
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Increased Heart Rate
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Decreased Heart Rate
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Increased Permeability to Calcium
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Increased Permeability to Sodium
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Increased Permeability to Potassium
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Hyperpolarisation
-
Depolarisation
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Acetylcholine is the neurotransmitter
-
Noradrenaline is the neurotransmitter
-
The neurotransmitter binds to Beta 1 Receptors.
Frage 10
Frage
Which of the following are TRUE regarding conduction velocity
Antworten
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Is the same across the heart
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Smaller fibres conduct faster than larger fibres
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Larger fibres conduct faster than smaller fibres
Frage 11
Frage
Which of the following are functions of the cardiac skeleton
Antworten
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It is always fortified by cartilage and bone
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Provides electrical discontinuity between atria and ventricles
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Provides support for the AV Valves
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Provides support for the Pulmonic and Aortic Valves
-
Provides an attachment site for ventricular muscles
-
Provides an attachment site for atrial muscles
-
Assists in Ventricular Contraction
Frage 12
Frage
Pacemaker Tissue is located in the
Antworten
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Epicardium
-
Myocardium
-
Endocardium
-
Pericardium
Frage 13
Frage
Adipose tissue can be found in the
Antworten
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Endocardium
-
Epicardium
-
Myocardium
-
Pericardium
Frage 14
Frage
Order the following events correctly
[blank_start]HBLIADECJFMKG[blank_end]
Your answer should be of the form ABCDE
Options:
A Activation of Ryanodine receptor channels in the Sarcoplasmic reticulum
B Opening of Voltage Gated Sodium Channels
C Tropomyosin shifts out of the actin cleft
D Influx of Calcium from the Sarcoplasmic Reticulum
E Calcium Binds to Troponin
F Crossbridge Cycle Occurs and Tension of Myocyte Increases
G Membrane Potential restored by the Na+/K+ ATPase and the Na+/Ca2+ Exchanger
H Depolarisation of Myocyte Above Threshold, Action Potential Initiated
I Influx of Calcium from the ECF
J Actin may now bind to Myosin
K Voltage Gated Calcium Channels Close
L Opening of Voltage Gated Calcium Channels
M Ca2+ ATPase activated, Calcium pumped back into the Sarcoplasmic Reticulum
Frage 15
Frage
Which of the following statements regarding an Isotonic Contraction are true?
Antworten
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Muscles fibres shorten but not force is developed
-
There is nothing to develop force against
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Muscle Shortens with Maximal Velocity
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Force generated at a Specific Length
-
Force generated at this length if a measure of the maximum ability to produce tension
-
Muscle shortens slowly
-
Muscle shortens with Maximal Force
Frage 16
Frage
Which of the following are likely to increase Afterload for the Left Ventricle
Antworten
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Increased sympathetic innervation
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Hypovolaemic Shock
-
Systemic Hypertension
-
Pulmonary Hypertension
-
Increased Parasympathetic Innervation
-
Stenotic Aortic Valve
-
Incompetent Aortic Valve
-
Stenotic Pulmonary Valve
-
Incompetent Pulmonary Valve
-
Impaired Venous Return
Frage 17
Frage
Preload is synonymous with
Antworten
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ESV
-
EDV
-
CO
-
Venous Return
-
SV
-
HR
-
Systolic Blood Pressure
-
Diastolic Blood Pressure
-
TPR
Frage 18
Frage
On Trace 1 Person A has leads attached to the upper arms and thighs. On Trace 2 Person A has leads attached to the forearms and lower legs.
If all other variables are constant, following Einthoven's Hypothesis, the ECG for Trace 1 and 2 would be identical.
Frage 19
Frage
The Magnitude of the Dipole on a ECG is determined by
Frage 20
Frage
A Dog has the positive lead on his left arm, and the negative lead on his right arm, and the ground lead attached to the right leg. This arrangement is described as:
Antworten
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Lead 1
-
Lead 2
-
Lead 3
-
None of the Above
Frage 21
Frage
Which lead is considered most useful
Frage 22
Frage
Atrial depolarisation occurs during the
Antworten
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P Wave
-
QRS Complex
-
T Wave
-
None of the Above
Frage 23
Frage
The T Wave is highly variable in domestic animals, it could be positive or negative deflection, or sometimes not even noticeable.
Frage 24
Frage
A Patient presents with a prolonged P-R Interval on their ECG. All other intervals are within normal range. This could suggest
Antworten
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A Delay between Atrial Depolarisation and Ventricular Depolarisation
-
A Blockage at the AV Node
-
Left Sided Congestive Heart Failure
-
Sinus Tachycardia
-
Sinus Bradycardia
Frage 25
Frage
Exercise, Anxiety and Fever would most likely cause
Antworten
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Sinus Tachycardia
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Sinus Bradycardia
-
Sinus Arrythmias
-
None of the above
Frage 26
Frage
A Patient presents with an absence of P waves on their ECG. The QRS and T Waves are normal.
The Patient most likely has a
Antworten
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SA Block
-
1st Degree AV Block
-
2nd Degree AV Block
-
3rd Degree AV Block
-
None of the Above
Frage 27
Frage
A Patient has a 3rd Degree AV Block. Which of the following features would you expect to be present on their ECG.
Antworten
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P wave and QRS/T Waves are Independent
-
P wave and QRS/T Waves are dependent, but have an abnormally long conduction time between them
-
There isn't 1 QRS complex for every P Wave
-
Ventricular Rate is Slow
-
Atrial Contraction is Slower than normal
Frage 28
Frage
A Patient's ECG shows QRS Complexes that are not always preceded by a clear P Wave. Which of the following are possible
Antworten
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VPC's
-
Paroxysmal Tachycardia
-
Atrial Fibrilation
-
Ventricular Fibrilation
-
AV Block
-
SA Block
Frage 29
Frage
Atrial Contraction contributes what percentage to ventricular filling?
Antworten
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0%
-
20%
-
40%
-
60%
-
80%
-
100%
-
50%
Frage 30
Frage
With an Increase in Heart Rate, Atrial Contribution to Ventricular filling also increases
Frage 31
Frage
During the 1st Phase of Ventricular Systole which of the following statements are true?
Antworten
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The contraction is Isometric
-
Ejection is Rapid
-
Mitral Valve is Closed
-
Tricuspid Valve is Closed
-
Aortic Valve is Closed
-
Pulmonary Valve is Closed
-
Atrial Pressure wave, c wave, occurs in the venous system
-
Pressure within the ventricle increases
-
Pressure within the ventricle decreases
-
Aortic Pressure Rises
Frage 32
Frage
Which of the statements regarding the Dichrotic Notch are incorrect
Antworten
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It occurs at the conclusion of Ventricular Systole
-
It is a result of blood flowing back into the leaves of Aortic Valve after it closes
-
Results in a sharp decrease in Aortic Pressure
-
Would be less noticeable in animal with an incompetent Aortic Valve
-
All the above are correct
Frage 33
Frage
Which of the following are incorrect
Antworten
-
Cardiac Output is proportional to Stroke Volume
-
An Increase in Heart Rate would result in a corresponding increase in Stroke Volume
-
EDV and Venous Return are synonymous
-
Ejection Fraction = SV/EDV
-
A decrease in Preload will decrease Cardiac Output
Frage 34
Frage
The 4th Heart Sound is caused by the vibration of ventricular wall due to deceleration of blood leaving the ventricles