Mechanisms of Cell injury

Beschreibung

Pathology (Introductory principles) Quiz am Mechanisms of Cell injury, erstellt von Kayleigh Van am 19/10/2016.
Kayleigh Van
Quiz von Kayleigh Van , aktualisiert more than 1 year ago
Kayleigh Van
Erstellt von Kayleigh Van vor mehr als 7 Jahre
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Zusammenfassung der Ressource

Frage 1

Frage
Terminology: 1. [blank_start]aetiology[blank_end]: cause of disease 2. [blank_start]pathogenesis[blank_end]: the mechanism of how disease develops 3. [blank_start]morphological changes[blank_end]: structural changes in tissues and organs 4. [blank_start]clinical significance[blank_end]: functional consequences 5. [blank_start]antemortem[blank_end]: before death 6. [blank_start]postmortem[blank_end]: after death 7. [blank_start]anatomical pathology[blank_end]: postmortem and tissue biopsy 8. [blank_start]gross pathology[blank_end]: postmortem with naked eye 9. [blank_start]histopathology[blank_end]: postmortem with microscope 10. [blank_start]clinical pathology[blank_end]: analysis of body fluids and cells
Antworten
  • aetiology
  • pathogenesis
  • morphological changes
  • clinical significance
  • antemortem
  • postmortem
  • anatomical pathology
  • gross pathology
  • histopathology
  • clinical pathology

Frage 2

Frage
ATP depletion is caused by [blank_start]hypoxia[blank_end] resulting in [blank_start]decreased[blank_end] oxidative posphorylation, [blank_start]decreased[blank_end] ATP, [blank_start]increased[blank_end] anaerobic glycolysis, [blank_start]decreased[blank_end] glycogen and decreased pH. the sodium potassium pump fails and ribosomes [blank_start]detach from[blank_end] the RER.
Antworten
  • hypoxia
  • free radicals
  • decreased
  • increased
  • decreased
  • increased
  • increased
  • decreased
  • decreased
  • increased
  • detach from
  • attach to

Frage 3

Frage
the three main causes of membrane damage are: 1. [blank_start]free radicals[blank_end] that cause lipid peroxidation 2. [blank_start]direct damage[blank_end] from chemicals, viruses etc. 3. [blank_start]Hypoxia[blank_end] resulting in ATP depletion.
Antworten
  • free radicals
  • direct damage
  • Hypoxia

Frage 4

Frage
the most reactive oxygen species are [blank_start]superoxide[blank_end], [blank_start]hydrogen peroxide[blank_end] and [blank_start]hydroxyl radical[blank_end].
Antworten
  • superoxide
  • hydrogen peroxide
  • hydroxyl radical

Frage 5

Frage
which of the following are sources of free radicals?
Antworten
  • by-products of oxidative metabolism
  • phagocytic cells
  • metals
  • organophosphates
  • reperfusion following necrosis
  • reperfusion following ischaemia
  • radiation and UV light
  • drug and chemical exposure
  • nitric oxide.

Frage 6

Frage
free radicals injure cells via: 1. [blank_start]lipid peroxidation[blank_end] leading to extensive membrane damage 2. [blank_start]DNA damage[blank_end] which causes sing strand breaks 3. [blank_start]protein damage[blank_end] which causes the oxidation of amino acids
Antworten
  • lipid peroxidation
  • DNA damage
  • protein damage

Frage 7

Frage
two patterns of reversible cell injury include: 1. [blank_start]hydropic degeneration[blank_end]: acute cell swelling due to fluid influx 2. [blank_start]fatty change[blank_end]: cell swelling due to lipid accumulation
Antworten
  • hydropic degeneration
  • fatty change

Frage 8

Frage
increased cytosolic calcium is associated with reversible cell injury.
Antworten
  • True
  • False

Frage 9

Frage
what type of cell injury is seen here microscopically? is it reversible?
Antworten
  • fatty change
  • hydropic degeneration
  • no it is not reversible
  • yes it is reversible

Frage 10

Frage
what type of cell injury is seen here grossly? is it reversible?
Antworten
  • fatty change
  • hydropic degeneration
  • no it is not reversible
  • yes it is reversible

Frage 11

Frage
what type of cell injury is seen here microscopically? is it reversible?
Antworten
  • fatty change
  • hydropic degeneration
  • no it is no reversible
  • yes it is reversible

Frage 12

Frage
what type of cell injury is seen here grossly? is it reversible?
Antworten
  • fatty change
  • hydropic degeneration
  • yes it is reversible
  • no it is not reversible.
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