BCM-FINAL, PT 1

Which of the following statements is FALSE regarding the binding of estradiol to the estrogen receptor?

Which of the following statements is not true regarding the actions of the estrogen receptor?

In the absence of hormone, estrogen receptor is not bound to DNA but to Hsp90. Estrogen binding displaces the receptor from Hsp90 and allows the formation of receptor dimers, which bind DNA and stimulates gene transcriptions.

Which of the following statements is the closest description of Phase I metabolism?

Which of the following statements is the closest description of Phase II metabolism?

Which of the following enzymes is not involved in catalyzing a Phase I metabolic reaction?

Where in the cell is cytochrome P450 located?

All of the following are detoxifying agents, except:

All of the following are true for cytochrome P450, except:

All of the following compounds are detoxified by sulfation, except:

All of the following are correct about a molecule designated as a cytochrome P450 except:

Flavoproteins are usually intermediates in the transfer of electrons from NADPH to cyt P450 because:

Benzo[a]pyrene, a xenobiotic produced by combustion of a variety of substances:

Which medication(s) should not be co-administered with grapefruit juice?

An adult patient has been taking a drug (Drug A) that is highly metabolized by the cytochrome P450 system. He has been on this medication for 6 months. At this time, he is started on a herbal remedy that is an inducer of cytochrome P450 system. You should monitor this patient for:

A 25-year-old male is seen in the hospital Emergency Department. He is disoriendted, but states that he has had nausea, vomiting and abdominal pain since he took “too many pain pills.” Upon examination, his eyes appear yellow. Laboratory tests indicate abnormal liver function (as determined by measurements of serum and bilirubin and liver-associated enzymes in the blood). In addition to gastric lavage, what is the appropriate treatment?

The enzyme NADPH-adrenodoxin reductase is associated with which of the following systems

Indicate which of the following statements concerning Phase I metabolic drug reactions are correct:

____ is responsible for the metabolism of the largest number of drugs.

When St. John’s wort and irinotecan are ingested concurrently significant decreases in plasma concentration of irinotecan can occur.

DNA ligase uses the energy of ATP to close nicks in DNA and this involves a mechanism which includes

Cells normally delay replication until DNA damage and replication errors have been repaired because

All of the following are correct about a Cytochrome P450 enzyme except:

Genetic polymorphism in genes for cytochrome P450:

NADHP-cytochrome P450 reductase:

Which of the following treatments would increase the likelihood of toxicity resulting from acetaminophen overdose?

How does the mismatch repair system distinguish between the parental (i.e. correct) DNA strand and the newly synthesized strand containing the mismatched base?

Genes that are “highly expressed” typically possess __________.

Which of the following statements is FALSE?

_____ is a chemical reaction of purine deoxyribonucleosides, deoxyadenosine and deoxyguanosine, in which the B-N-glycosidic bond is hydrolytically cleaved releasing a free base.

Match the following types of DNA damage to DNA repair system responsible for their repair.

Match the following types of DNA damage to DNA repair system responsible for their repair.

Which of the following statements are FALSE?

Flavoproteins are usually intermediates in the transfer of electrons from NADPH to cyt P450 because:

Which of the following statements regarding NADPH-cytochrome P450 reductase is CORRECT?

Benzo[a]pyrene, a xenobiotic produced by combustion of a variety of substances:

The DNA double helix structure is STABILIZED by all of the following EXCEPT:

The enzymatic activity of HIV reverse transcriptase is best described as:

All are characteristics of RNA-directed DNA polymerase EXCEPT:

A solution contains DNA polymerase I, Mg2+ salts of dATP, dGTP, dCTP, and dTTP, and an appropriate buffer. Which of the following DNA molecules would serve as a template for DNA synthesis when added to this solution?

The PROOFREADING activity of E. coli DNA polymerases:

An Okazaki fragment is a:

The proofreading function of DNA polymerase involves all of the following except:

Which of the following statements about DNA polymerase reaction is FALSE?

The enzyme that seals nicks in the dsDNA where a 3’-OH and 5’-phosphate is:

Zidovudine (AZT) is a more effective inhibitor of HIV reverse transcriptase than of mammalian cell DNA polymerases because:

AZT, the first drug approved use against the human immunodeficiency virus (HIV). Before the drug can inhibit the viral transcriptase, it must be converted to a form of nucleotide by:

Acyclovir was one of the first highly selective antiviral agents for Herpes simplex virus. Which of the following statements about acyclovir are TRUE? I. Acyclovir is phosphorylated by virus thymidine kinase to form acyclovir monophosphate II. Acyclovir monophosphate is phosphorylated by cellular kinases to form acyclovir triphosphate III. Acyclovir triphosphate is a competitive inhibitor for DNA polymerase, incorporated into growing polynucleotide chains in the place of guanosine residues

One of the functional differences between DNA polymerases and RNA polymerases is that, unlike DNA polymerases, RNA polymerases

The flow of genetic information in Central Dogma of Biology (included the retroviruses) is as follows:

Which of the following statements about Pregnane X receptor (PXR) is FALSE?

If a female patient was already taking an oral contraceptive (i.e., birth control pill), what best describes the advice you would provide to her regarding St. John’s wort?