7295718
Frage 1
Frage
Bactericidal drugs kill bacteria.
Antworten
- True
- False
Frage 2
Frage
Which class of drugs slows bacterial growth?
Antworten
-
Bactericidal
-
Bacteriostatic
Frage 3
Frage
When a bacteriostatic drug is added to an in vitro colony of bacteria, what will happen to the the number of bacteria?
Antworten
-
Increase
-
Decrease
-
Stay the same
Frage 4
Frage
When a bactericidal drug is added to an in vitro colony of bacteria, what will happen to the the number of bacteria?
Antworten
-
Increase
-
Decrease
-
Stay the same
Frage 5
Frage
When a bacteriostatic drug is removed from an in vitro colony of bacteria, what will happen to the the number of bacteria?
Antworten
-
Increase
-
Decrease
-
Stay the same
Frage 6
Frage
When a bactericidal drug is removed from an in vitro colony of bacteria, what will happen to the the number of bacteria?
Antworten
-
Increase
-
Decrease
-
Stay the same
Frage 7
Frage
Are the actions of sulphonamides bactericidal or bacteriostatic?
Antworten
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Frage 8
Frage
Is the action of trimethaprim bactericidal or bacteriostatic?
Antworten
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Frage 9
Frage
Are the actions of tetracyclines bactericidal or bacteriostatic?
Antworten
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Frage 10
Frage
Is the action of chloramphenicol bactericidal or bacteriostatic?
Antworten
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Frage 11
Frage
Is the action of linomycin bactericidal or bacteriostatic?
Antworten
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Frage 12
Frage
Is the action of erythromycin (macrolides) bactericidal or bacteriostatic?
Antworten
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Frage 13
Frage
Are the actions of penicillins bactericidal or bacteriostatic?
Antworten
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Frage 14
Frage
Are the actions of cephalosporins bactericidal or bacteriostatic?
Antworten
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Frage 15
Frage
Are the actions of fluoroquinolones bactericidal or bacteriostatic?
Antworten
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Frage 16
Frage
Are the actions of aminoglycosides bactericidal or bacteriostatic?
Antworten
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Frage 17
Frage
Is the action of metronidazole bactericidal or bacteriostatic?
Antworten
-
Bactericidal
-
Bacteriostatic
-
Concentration dependent
Frage 18
Frage
A potentiated sulphonamide refers to which of the following combinations of antibacterial agents?
Antworten
-
Sulphonamide and Erythromycin
-
Sulphonamide and Fluoroquinolone
-
Sulphonamide and Trimethoprim
-
Sulphonamide and Chloramphenicol
-
Sulphonamide and Cephalosporin
Frage 19
Frage
What is the main aim for optimum efficacy of a time dependent drug?
Antworten
-
Plasma levels should be above minimum inhibitory concentration (MIC) for as long as possible in each 24 hour period
-
Plasma levels should be as high as possible for as long as possible
-
The dosage is irrelevant, but the drug must be in the system for as long as possible
Frage 20
Frage
Which of the following drugs is time dependent?
Antworten
-
Aminoglycoside
-
Penicillin
-
Fluoroquinolones
-
Metronidazole
Frage 21
Frage
Which of the following drugs is time dependent?
Antworten
-
Aminoglycoside
-
Cephalosporin
-
Fluoroquinolone
-
Metronidazole
Frage 22
Frage
Which of the following drugs are concentration dependent?
Antworten
-
Penicillin
-
Aminoglycoside
-
Metronidasole
-
Cephalosporin
-
Fluoroquinolone
Frage 23
Frage
Where are NAMA and NAG synthesised?
Antworten
-
Cytoplasm
-
Membrane
-
Extra-membrane
Frage 24
Frage
How many peptides are initially attached to NAMA?
Antworten
-
3
-
4
-
5
-
6
Frage 25
Frage
What is the most important feature for the activity of a penicillin/cephalosporin?
Antworten
-
Ring of 2 carbons and 2 nitrogens
-
Ring of 3 carbons and 1 nitrogen
-
Ring of 5 carbons
-
Ring of 5 carbons and 1 nitrogen
-
Ring of 4 carbons and 2 nitrogens
Frage 26
Frage
What determines the antibacterial activity of β-lactams?
Antworten
-
R side chain
-
Ability to bind to peptidyl transferase
-
Ability to bind to transpeptidases
-
Drug size
-
Ability to bind to gamma-glutamyl transpeptidase
Frage 27
Frage
The ability for penicillin to access transpeptidase is limited in gram +ve bacteria.
Antworten
- True
- False
Frage 28
Frage
Clavulanic acid has an antibacterial effect when administered alone.
Antworten
- True
- False
Frage 29
Frage
Which of the following drugs would be best paired with clavulanic acid?
Antworten
-
Mecillinam
-
Cloxacillin
-
Benzylpenicillin
-
Methicillin
-
Amoxicillin
Frage 30
Frage
Benzylpenicillin has good acid stability.
Antworten
- True
- False
Frage 31
Frage
Which of the following drugs are susceptible to β-lactamase activity?
Antworten
-
Benzylpenicillin
-
Penicillin V
-
Cloxacillin
-
Methicillin
-
Ampicillin
-
Amoxicillin
-
Carbenicillin
-
Mecillinam
Frage 32
Frage
Which of the following drugs are not susceptible to β-lactamase activity?
Antworten
-
Cloxacillin
-
Benzylpenicillin
-
Methicillin
-
Mecillinam
-
Carbenicillin
Frage 33
Frage
Which of the following drugs are most effective against Gram +ve cocci?
Antworten
-
Benzylpenicillin
-
Mecillinam
-
Penicillin V
-
Cloxacillin
-
Methicillin
Frage 34
Frage
Which of the following drugs is most active against Gram -ve bacteria?
Antworten
-
Mecillinam
-
Methicillin
-
Cloxacillin
-
Carbenicillin
Frage 35
Frage
Which of the following drugs is efficacious against pseudomonas?
Antworten
-
Mecillinam
-
Cloxacillin
-
Carbenicillin
-
Methicillin
Frage 36
Frage
Which generations of cephalosporins are unstable in acid?
Antworten
-
1st generation
-
2nd generation
-
3rd generation
-
4th generation
Frage 37
Frage
Which generation of cephalosporin has the least β-lactamase stability?
Antworten
-
1st generation
-
2nd generation
-
3rd generation
-
4th generation
Frage 38
Frage
Which generations of cephalosporin are least susceptible to β-lactamase activity?
Antworten
-
1st generation
-
2nd generation
-
3rd generation
-
4th generation
Frage 39
Frage
Which of the following drugs is most efficacious against gram +ve bacteria?
Antworten
-
Cephalexin
-
Cefuroxime
-
Cefovecin
-
Cefquinome
Frage 40
Frage
Which of the following drugs is most efficacious against gram -ve bacteria?
Antworten
-
Cephradine
-
Cephalexin
-
Cefquinome
-
Cefovecin
Frage 41
Frage
Which of the following drugs is efficacious against pseudomonas?
Antworten
-
Cephradine
-
Cefovecin
-
Cefquinome
-
Cefuroxime
Frage 42
Frage
Penicillins and cephalosporins are eliminated by the liver.
Antworten
- True
- False
Frage 43
Frage
Penicillins do not cross the BBB, despite being widely distributed.
Antworten
- True
- False
Frage 44
Frage
Some cephalosporins cross the BBB.
Antworten
- True
- False
Frage 45
Frage
Aminoglycosides induce a long lasting mutation in bacteria, so are risky to use given that resistance may easily occur.
Antworten
- True
- False
Frage 46
Frage
What type of bacteria are aminoglycosides more efficacious against?
Antworten
-
Gram -ve anaerobic bacteria
-
Gram -ve aerobic bacteria
-
Gram +ve anaerobic bacteria
-
Gram +ve aerobic bacteria
Frage 47
Frage
Aminoglycosides are typically bactericidal.
Antworten
- True
- False
Frage 48
Frage
Aminoglycosides have poor oral bioavailability.
Antworten
- True
- False
Frage 49
Frage
How are aminoglycosides eliminated from the body?
Antworten
-
Liver metabolism
-
Renal excretion
-
Excreted in bile
-
Metabolism in muscles
Frage 50
Frage
How do macrocodes inhibit bacteria protein synthesis?
Antworten
-
Bind to ‘A’ site, prevent initiation
-
Bind to ‘P’ site, prevent translocation
-
Bind to ‘E’ site, prevent translocation
-
Bind to ‘A’ site, prevent termination
Frage 51
Frage
What type of bacteria are macrocodes more efficacious against?
Antworten
-
Gram -ve
-
Gram +ve
Frage 52
Frage
Macrocodes have poor oral bioavailability.
Antworten
- True
- False
Frage 53
Frage
How are macrolides eliminated from he body?
Antworten
-
Metabolised by liver
-
Renal excretion
-
Excreted in bile
-
Metabolism in muscles
Frage 54
Frage
At doses normally used in veterinary practice, erythromycin is bactericidal.
Antworten
- True
- False
Frage 55
Frage
How do lincosamides inhibit bacteria protein synthesis?
Antworten
-
Bind to 'A' site, prevent initiation
-
Bind to 'P' site, prevent elongation
-
Bind to 'E' site, prevent elongation
-
Bind to 'E' site, prevent termination
Frage 56
Frage
How do tetracyclines inhibit bacterial protein synthesis?
Antworten
-
Bind to 'A' site, prevent initiation
-
Bind to 'P' site, prevent elongation
-
Bind to 'E' site, prevent elongation
-
Bind to 'E' site, prevent termination
Frage 57
Frage
Which class of bacteria are tetracyclines most effective against?
Antworten
-
Gram +ve aerobes
-
Gram +ve anaerobes
-
Gram -ve aerobes
-
Gram -ve anaerobes
-
Wide spectrum against aerobic and anaerobic Gram +ve and –ve bacteria
Frage 58
Frage
Tetracyclines have a bacteriostatic effect.
Antworten
- True
- False
Frage 59
Frage
How are tetracyclines eliminated from the body?
Antworten
-
Metabolism by the liver
-
Renal excretion
-
Excreted in bile
-
Metabolism by muscles
Frage 60
Frage
Tetracyclines inhibit mammalian protein synthesis. Why are the side effects not more severe than those observed if this is the case?
Antworten
-
The drug is delivered directly to the site of action, minimising the systematic effect
-
The concentration is not high enough to affect mammalian cells
-
Mammalian cells do not efficiently transport tetracyclines across cell membrane
-
Tetracyclines on affect cells with a cell wall
Frage 61
Frage
How does chloramphenicol inhibit bacterial protein synthesis?
Antworten
-
Binds to 'A' site, inhibits initiation
-
Binds to 'P' site, inhibits elongation
-
Inhibits peptide bond formation
-
Binds to 'E' site, inhibits termination
Frage 62
Frage
Chloramphenicol is banned in food-producing animals
Antworten
- True
- False
Frage 63
Frage
Chloramphenicol had poor oral bioavailability.
Antworten
- True
- False
Frage 64
Frage
Chloramphenicol can cross the BBB.
Antworten
- True
- False
Frage 65
Frage
Chloramphenicol has a bacteriocidal effect.
Antworten
- True
- False
Frage 66
Frage
How is chloramphenicol eliminated from the body?
Antworten
-
Liver metabolism
-
Renal excretion
-
Excreted in bile
-
Metabolised in muscles
Frage 67
Frage
In which class of bacteria is chloramphenicol most efficacious?
Antworten
-
Gram positive aerobes
-
Gram negative aerobes
-
Obligate anaerobes
-
Penicillinase producing - Staphylococcus
Frage 68
Frage
Which of the following drugs affect folate synthesis?
Antworten
-
Cyclosporins
-
Chloramphenicol
-
Sulphonamides
-
Tetracycline
-
Trimethoprim
Frage 69
Frage
Which class of bacteria are sulphonamides most efficacious against?
Antworten
-
Gram -ve anaerobes
-
Gram - aerobes
-
Gram +ve anaerobes
-
Gram +ve aerobes
-
Wide spectrum against Gram +ve and –ve bacteria
Frage 70
Frage
Sulphonamides have poor oral bioavailability.
Antworten
- True
- False
Frage 71
Frage
Sulphonamides can cross the BBB.
Antworten
- True
- False
Frage 72
Frage
How are sulphonamides excreted from the body?
Antworten
-
Metabolised by the liver
-
Renal excretion
-
Excreted in bile
-
Metabolised by muscles
Frage 73
Frage
Sulphonamides have a bacteriostatic effect.
Antworten
- True
- False
Frage 74
Frage
How does trimethoprim affect bacterial folate synthesis?
Antworten
-
Inhibits uptake of p-aminobenzoic acid (PABA)
-
Inhibits dihydropteroate synthetase (DHPS)
-
Inhibits dihydropteroate reductase (DHPR)
-
Inhibits dihydrofolate synthetase (DHFS)
-
Inhibits dihydrofolate reductase (DHFR)
Frage 75
Frage
How are fluoroquinolones eliminated form the body?
Antworten
-
Metabolised by liver
-
Renal excretion
-
Excreted in bile
-
Metabolised by muscles
Frage 76
Frage
Fluoroquinolones have poor oral bioavailability
Antworten
- True
- False
Frage 77
Frage
Fluoroquinolones have a bactericidal effect.
Antworten
- True
- False
Frage 78
Frage
Which class of bacteria is metronidazole most efficacious against?
Antworten
-
Gram positive aerobes
-
Gram negative aerobes
-
Obligate anaerobes
-
Penicillinase producing Staphylococcus
Frage 79
Frage
Metronidazole has good oral bioavailability
Antworten
- True
- False
Frage 80
Frage
Metronidazole can cross the BBB.
Antworten
- True
- False
Frage 81
Frage
How is metronidazole eliminated from the body?
Antworten
-
Metabolised by the liver
-
Renal excretion
-
Biliary excretion
-
Metabolised by muscles
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