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What determines the shape of the TMS coils?
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How is TMS used in research?
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What are clinical applications of TMS?
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This option is available in Victoria (e.g., the Victoria Clinic) for depression
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Shock therapy and hyponosis
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To disable a problematic part of the brain permantly
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To subdue a distressed person to sleep
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What are some advantages of EGG?
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It is cheap and relatively easy to conduct
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Temporal resolution is sound
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A and B
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The patient is conscious
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You don't have to be trained to use it
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Essentially one compares the BOLD fMRI signals coming from the brain in two situations
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the control and experimental task
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the control, experimental task and a task to demonstrate the instructions
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the control, experimental task and a task to demonstrate the instructions and a task to calm them down
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the control, experimental task and a task to demonstrate the instructions and a task to calm them down and another to measure the size/dynamics of the brain
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ERP studies are used for:
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Testing the ability of post trauma patients
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Healing parts of the brain
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Teach post trauma patients to rewire thier neurons
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To study components of well established cognitive processes
Frage 7
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Signals in the sulci are harder to detect than from gyri, and may additionally be masked by the signals from the gyri
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A and D
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The poor spacial resolution makes it difficult to determine location of ERP
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The orientation of the neurons determines the sign of the recorded potentials - Some orientations lead to signals which cannot be recorded.
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What adv does fMRI have over PET scans?
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fMRI doesn't need radiation
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fMRI is cheaper and easier to use
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fMRI the patient can be awake
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fMRI allows for 3D views of the brain
Frage 9
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Blood Oxygen Level-Dependent
Because the brain sends so much blood to the active area, the oxygen content of the blood actually increases
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The type of scanning signal
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Blood Oxygen Leverage-Dependent
The net gradient in change that occurs when brain activity spikes and the brain loses oxygen
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Blood Oxytocin Level-Dependent
Because the patent is nervous, we accept a level of oxycotin spike and compare it against the normal rate
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What is a disadv of BOLD fMRI ?
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if two neural events occur within about two seconds of each other, the BOLD fMRI responses to the two events will become confused. Maximum temporal resolution is about 2 seconds.
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f a given neuron “requests” more blood, all neighbouring neurons within about 1 mm of it will receive an increased blood flow.
Thus, if two neural events occur within 1 mm of each other, BOLD fMRI will not be able to distinguish them.
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A and B
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neither: BOLD measurement compensates for these flaws
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What is a safety concern with fMRI measurements?
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The patient may be claustrophibic
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Any ferromagnetic object brought too close will literally fly into the magnetic, destroying whatever is inside the magnet (e.g. the patient)
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The liquid hydrogen could leak
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None of the above
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Getting he procedure wrong can resultin patient brain injury
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Which process states the physics of the brain scan correctly
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None of the below: the process is molecular
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The slower the decay rate, the greater the neural activity, thus we drip feed signals and see how long it takes for the brain to stop responding completely
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The slower the decay rate, the greater the neural activity.
we excite the brain with an RF pulse.
Then we measured the RF pulse emitted in turn by the brain.
By measuring how long the brain’s RF pulse takes to decay we can infer the neural activity in that region of the brain.
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we excite the brain with an RF pulse.
Then we measured the RF pulse emitted in turn by the brain.
By measuring how long the brain’s RF pulse takes to decay we can infer the neural activity in that region of the brain.
The slower the decay rate, the greater the neural activity.
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Cririsms of fMRI include:
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Multiple Comparisons Problem- multiple comparisons problem: the more t tests you do, the greater chance there is of reporting a false positive, solved by preforming a Bonferoni Correction test
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All answers are correct
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Over Interpretation of Null Results: the failure to prove that a given brain area is involved in a particular task does not prove that the brain area is not involved in the task
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Non-independent sample selection : use different scanning sessions for the identification and testing of the ROI.
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Epilepsy is caused by:
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Inhibitory-excitatory balance: GABA and
glutamate, due to a reduction in GABA
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Inhibitory-excitatory balance: GABA and
glutamate, due to a reduction in glutamine
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Neurons going through apoptosis at an alarming rate
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None of the above
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TLE Epilepsy involves
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Recurrent unprovoked seizures originating
from medial (middle/inner or lateral towards the outside temporal lobe”
Simple partial seizures (without loss of awareness)
AND Complex partial seizures (with loss of awareness)
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Recurrent unprovoked seizures originating
from medial (middle/inner or lateral towards the outside temporal lobe”
Simple partial seizures (without loss of awareness) but not
Complex partial seizures (with loss of awareness)
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Recurrent unprovoked seizures originating
from medial (middle/inner or lateral towards the outside temporal lobe”
Not, Simple partial seizures (without loss of awareness) but actually
Complex partial seizures (with loss of awareness)
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None of the above
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Hippocampal formation is essential for what functions?
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necessary for relational memory tasks eg Paired Associate Learning tasks
Information is integrated in sensory systems,
sent to hippocampal formation for long-term
storage.
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Information is integrated in sensory systems,
sent to hippocampal formation for long-term
storage.
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necessary for relational memory tasks eg Paired Associate Learning tasks
Information is integrated in sensory systems,
sent to hippocampal formation for long-term
storage.
Connecting to the temporal neocortex
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all of the above
Frage 17
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27 y.o. man with severe temporal
lobe epilepsy
Underwent bilateral
resection of extensive amount of
medial temporal tissue. Normal attention span, preserved
intelligence
Retrograde memory essentially recovered
over time. Severe anterograde amnesia
– Declarative Declarative memory: conscious access to
information learned previously. Severely impaired vs. procedural memory: remembering ‘how to’. Was ok.
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27 year old man who suffered a serious injury by an iron rod piercing his head and frontal cortex
This led to severe changes in his personality in the 50s
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Suffered DAT and diagnosed with the disease after memory assessment
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50 year old man who suffered a serious injury by an iron rod piercing his head and frontal cortex
This led to severe changes in his personality in the 50s
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what does damage to papez circuit result in?
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result in declarative memory impairment
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result in declarative memory impairment and procedural memory
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damage to episodic and procedural memory
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damage to rely to the amygdala
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What was the research question in Amassian et al. (1989) classical TMS study?
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They investigated error processing by applying TMS during the time window of the ERN.
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They investigated the effects of TMS over primary visual cortex on the perception of letter stimuli.
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They investigated the effects of TMS over prefrontal cortex on the perception of letter stimuli.
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They investigated the effects of TMS over primary motor cortex on mental rotation
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The maximum temporal resolution of fMRI is approximately
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2 ms
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20 ms
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200 ms
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2000 ms
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Which of the following is a safety concern for fMRI?
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It involves ingesting a radioactive isotope.
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The machine may cause people to feel claustrophobic.
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Patients must fast before having an fMRI scan.
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It should not be administered to patients with epilepsy.
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What is a typical EEG amplitude?
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10μV to 100μV
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1000μV to 100000μV
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20μV to 200μV
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1μV to 10μV
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Which of the following is NOT one of the four TMS techniques discussed in the lectures?
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The "probing excitability" approach
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The injection of "neural noise"
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The "simultaneous-pulse approach"
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The creation of a "virtual lesion"
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The biochemical basis of epileptic seizures is:
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an inhibitor that binds to receptors on the post-synaptic membrane, preventing the uptake of glutamate.
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lesions to the medial or lateral temporal lobe.
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oversecretion of glutamate.
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a reduction in GABA uptake.
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What is an advantage of the Electroencephalograph?
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The temporal resolution is good
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It is not biased to signals generated in superficial layers of cerebral cortex
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The spatial resolution is good
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Signals from the sulci are easy to detect
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The memory deficit detailed in the case study of HM is ____ because HM ___
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anterograde amnesia; could not remember events from before the incident but could create new memories.
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retrograde amnesia; could not remember events from before the incident but could create new memories.
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anterograde amnesia; had access to long-term memory from before the incident but was unable to create new memories post injury.
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retrograde amnesia; had access to long-term memory from before the incident but was unable to create new memories post injury
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How will a 46 year old individual presenting with two forms of cognition deficits, both amnestic and non-amnestic be diagnosed, according to McKhann et al's criteria for Alzheimer's Disease?
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How does TMS-induced currents affect neurons?
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TMS-induced current causes all neurons within a circumscribed area of cortex to fire towards the anterior and posterior sections of the brain
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TMS-induced current causes all neurons within a circumscribed area of cortex to fire randomly
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TMS-induced current causes all neurons within a circumscribed area of cortex to fire in a path align with the magnetic field path
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TMS-induced current causes all neurons within a circumscribed area of cortex to fire all in the same direction
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What is the main danger associated with fMRI?
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what does the bold fMRI measure?
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the oxygen level in the blood
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the magnetic field of the brain
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the neural activity in the brain
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After his operation, HM had trouble with
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A lesion on the left medial temporal lobe results in
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Out of four children, one of the girls and one of the boys in a family both share a genetic biological condition. Through genetic family tree mapping, you find out that none of their parents, uncles, aunties and grandparents share this condition. If we are looking at the daughter, what mode of inheritance is this gene?
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Autosomal Recessive
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Autosomal Dominant
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X-Linked Recessive
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None of the above
Frage 34
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a form of malfunctioned nuerotransmitter
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A fault in an action potential where it hyperpolizerses for too long
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When an axon of cell A…excites cell B and repeatedly or persistently takes part in firing it, some growth process or metabolic change takes place in one or both cells so that A’s efficiency as one of the cell’s firing B is increased” Cell B responds more vigiously to cell A next time
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A form of neuron death
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Declarative memory is _________ with 2 divisions______
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a result of procedual memory; explicit and implicit memory
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Accumulation of facts/data derived from learning experiences
outcome of processing by various processing systems, which feed the hippocampal formation; Semantic and Episodic
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Declarative memory is the result of episdic/semantic memory processes
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Is relational/connective in nature, links between memories rent context based and thus 2 divisions dont exist
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which model is most useful for studing amnesia?
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Serial models
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Parralel models
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Turving's SPI hypothesis states:
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Episodic memory is an extension of semantic memory
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Semantic memory is in charge of episodic memory
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Retrieval can be supported by either system
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A and C are correct
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VK study does or doesn't fit in SPI hypothesis:
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Whilst there are no definite causes of DAT, some risk factors
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What is the key difference between the 2 following points in McKhann's et al. DAT criteria?
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PrAD, unlike probA, is assessment in life, the other after death
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In possible AD, the patient has been by a neuropsychologist if there is variance in the presentation of symptoms, whereas probable AD simply involves the presentation of non-amnesia symptoms
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There is no difference; on is a continuation of the other
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Possible AD is assessed by the family, probable by a professional
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The pathology of DAT involves
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What is te first stage of amnesic presentation
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MTL impairment (Antero-retrograde memory)
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Prefrontal cortex degradation
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PTL impairment (word finding difficulties)
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Paritial lobe (visiospacial difficulties)
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MK symptoms include:
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All of the below
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Word finding difficulties due to posterior temportall lobe damage
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Visiospacial difficulties suggest parietal tlobe damage
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Recognition and recall memory impairment suggesting MTL impairment
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The hippocampal formation:
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Is made up of the entorhinal and perirhinal cortices
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Is part of the lateral temporal lobes
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Includes the dentate gyrus and subiculum
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None of the above
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Temporal lobe epilepsy:
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Has taught us much about the semantic memory system
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Usually causes seizures that are barely noticeable to an observer
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None of the these
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Is not usually associated with memory impairment
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Which of the following statements is FALSE?
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The frontal lobes incorporate primary memory systems
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The frontal lobes are essential for relating arbitrarily related pieces of information
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Damage to the thalamus is unlikely to result in memory impairment
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All of the above
Frage 47
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Explains autonoetic awareness
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Describes longterm depression
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Describes longterm potentiation
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Explains why depression can cause memory impairment
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Because fMRI is non-radioactive the same subject can be scanned repeatedly.
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true
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false
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depends on the subject
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depends on the scanner
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Longterm potentiation is important because:
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It describes how excitatory post synaptic potentials increase as a result of increased stimulus frequency
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It brings about temporary chemical changes that underpin memory function
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It only occurs in the temporal lobes and proves that this is the site of primary memory function
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It describes how inhibitory post synaptic potentials increase as a result of decreased stimulus frequency
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Explicit and implicit memory:
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Are the same thing as declarative and procedural memory
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Are distinguished partially on the basis of whether conscious recollection is used
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Are useful concepts in understanding human amnestic syndromes
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Both requrie that the learning and recall environments are the same
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The maximum spatial resolution of fMRI is approximat
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0.1 mm
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1 mm
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10 mm
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none of the above
Frage 52
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Vargha-Khadem’s ‘children’:
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Revealed important insights about the role of the frontal lobes in memory
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Demonstrated that the lateral temporal neocortex is essential for semantic memory function
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Indicated that episodic memory and semantic memory can show a single dissociation in performance during encoding
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None of the above
Frage 53
Frage 54
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and semantic memory are both memory systems that make mental "time travel" possible, according to Tulving
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Contains semantic memory within it
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Relies on the hippocampal circuit
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All of the above
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Bonferroni corrections are used to address
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the multiple comparisons problem
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statistical relevance
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the non-independent sample selection bias
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the problem of over-interpreting a null result
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Dementia of the Alzheimer’s type (DAT):
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Cannot be diagnosed during life
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Is the dementing syndrome associated with Alzheimer’s disease
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Can be successfully treated with anti-epileptic drugs
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Is the process of normal ageing speeded up
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fMRI records radio frequency signals emitted by
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hydrogen atoms
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hydrogen nuclei
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oxygen atoms
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oxygen nuclei