Frage 1
Antworten
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has endocrine functions
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is lined by a single layer of epithelial cells
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is under endocrine control
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absorbs more ions and molecules than it secretes
-
all of the above
Frage 2
Frage
The control of water excretion in the kidney is controlled by:
Antworten
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the antidiuretic hormone (ADH)
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the medulla oblongata
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blood plasma
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sodium amount in the blood
-
potassium amount in the blood
Frage 3
Frage
The kidneys have a direct effect on which of the following?
Frage 4
Frage
Glucose reabsorption occurs in the:
Frage 5
Frage
Renin is secreted by:
Antworten
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cells in the macula densa
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cells in the proximal tubule
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cells in the distal tubule
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juxtaglomerular cells
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cells in the peritubular capillary bed
Frage 6
Antworten
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is promoted by reduced arteriolar stretch in. the glomeruli
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increases when systemic arterial pressure rises
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directly activates angiotensin converting enzyme
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tends to expand the plasma volume
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a and d
Frage 7
Antworten
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has both afferent and efferent arterioles
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contains capillaries, which are at a higher hydrostatic pressure than the peritubular capillaries
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filters 20% of the renal plasma flow
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contains renin-secreting cells
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all of the above
Frage 8
Frage
The acid-buffering power:
Antworten
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of HCO3- in blood is increased by respiratory control of pCO2
-
of haemoglobin exceeds that of HCO3- in blood
-
of HCO3- is increased by the action of carbonic anhydrase
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of venous blood is normally greater than that of arterial blood
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a, b, and d
Frage 9
Frage
Urinary volume is increased with:
Frage 10
Frage
The following occurs in the proximal tubule of the nephron:
Antworten
-
reabsorption of all glucose
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reabsorption of most water
-
active reabsorption of sodium
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secretion of bicarbonate
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a, b, and c
Frage 11
Frage
The antidiuretic hormone (ADH):
Antworten
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decreases the osmolarity of urine
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decreases the volume of urine
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increases the reabsorption of water in the proximal tubules
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is synthesised in the posterior posterior pituitary gland
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increases the excretion of glucose
Frage 12
Frage
Regarding the kidneys:
Antworten
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there are 1.3 million nephrons in each kidney
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they produce aldosterone
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they receive 12% of the cardiac output at rest
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more blood flows through the renal cortex than the renal medulla
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a, and d
Frage 13
Frage
Which of the following causes hyperkalemia
Frage 14
Frage
Glucose is reabsorbed:
Antworten
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by active transport
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by passive transport
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by Na+ co-transport
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by H+ counter-transport
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a, and c
Frage 15
Frage
Simulation of the sympathetic nerves cause the following effects;
Antworten
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low diuresis
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decreased net filtration pressure
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increased glucose urine level
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decreased glucose urine level
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a, and b
Frage 16
Frage
The glomerular capillaries have the following functions:
Frage 17
Frage
Obligatory water loss from the body is:
Antworten
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400 ml in faeces
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300 ml from the lungs
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loss from skin & lungs
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insensible water loss
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500 ml in urine
Frage 18
Frage
Blood flow at rest is most for:
Antworten
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brain
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liver
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kidneys
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heart
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skin
Frage 19
Frage
Renal blood flow is dependent on:
Frage 20
Frage
Which of the following substances has the highest renal clearance?
Antworten
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PAH
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Glucose
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Urea
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Water
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Insulin
Frage 21
Frage
The ascending limb of the loop of Henle is:
Antworten
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impermeable to Na+
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involved in active transport of K+ into the lumen
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involved in active transport of Cl- out of lumen
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involved in active transport of Na+ into lumen
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hypotonic at the top
Frage 22
Frage
Which of the following ls involved in the regulation of glomerular filtration rate (GFR)?
Frage 23
Frage
Water excretion by the kidney is due to:
Frage 24
Antworten
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Erythropoietin
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ADH
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Angiotensin ll
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ANP
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Cholecalciferol
Frage 25
Frage
Increase in GFR occurs when there is:
Frage 26
Frage
The clearance (or ‘renal regulation') of which one of the following is not regulated by a hormone:
Antworten
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sodium
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potassium
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calcium
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phosphate
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sulphate
Frage 27
Frage
The kidneys filter from the blood every day about:
Antworten
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1000 ml
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180 l
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18 l
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50 l
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8 l
Frage 28
Frage
Direct control of water excretion in the kidney is controlled by:
Frage 29
Frage
Kidneys have a direct effect on which of the following:
Frage 30
Frage
The countercurrent exchange system includes:
Antworten
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glomerulus and macula densa
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proximal convoluted tubule and distal convoluted tubule
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loop of Henle and collecting tubule
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afferent arteriole and efferent arteriole
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ureters and bladder
Frage 31
Frage
Tubular reabsorption of a filtered substance is likely to be active rather than passive if:
Antworten
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its concentration in the tubular fluid is lower than in peritubular capillary blood
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is carried out by the mechanism of simple diffusion
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renal clearance is lower than that of insulin
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renal clearance rises at low plasma levels
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osmolality there is higher than the plasma one
Frage 32
Frage
The renal clearance of a substance:
Antworten
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is inversely related to its urinary concentration, U
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is directly related to the rate of urine formation, and is expressed in units of volume per unit time
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is directly related to its plasma concentration, P
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is expressed in mm Hg
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must fall in the presence of metabolic poisons
Frage 33
Frage
In the fluid in the distal part of the proximal convoluted tubule:
Antworten
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urea concentration is higher than in Bowman’s capsule
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pH is less than 6 when the kidneys are excreting an acid urine
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glucose concentration is similar to that in plasma
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osmolality is about 25 per cent that of glomerular filtrate
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bicarbonate concentration is higher than in plasma
Frage 34
Frage
Renal tubules normally reabsorb:
Antworten
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fluids with osmolality lower than the plasma one
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all filtered HCO3- in respiratory alcalosis
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substances closely related to Cl-
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all filtered plasma proteins
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more K+ and Cl-
Frage 35
Frage
In the nephron, the osmolarity or the fluid in the:
Antworten
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Tip of the loop Of Henle is less than that of plasma
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Bowman's capsules is less than that in the distal tubules
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Collecting duct rises when vasopressin is being secreted
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Proximal convoluted tubule rises along its length
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Proximal tubule is with lower osmolality than plasma one
Frage 36
Frage
Transport maximum (Tm) - limited reabsorption of a substance implies that its:
Antworten
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reabsorption is active
-
reabsorption is critically related to tubular transit time
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reabsorption is passive
-
renal clearance falls with its plasma concentration
-
reabsorbtion is carried out by the mechanism of faciliated diffusion
Frage 37
Frage
When a patient’s mean arterial blood pressure falls by 50%
Antworten
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renal blood flow increases
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glomerular filtration increases
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there is a decrease in the circulating aldosterone level
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renal vasoconstriction occurs
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urinary output is increased
Frage 38
Frage
The cells of the distal convoluted tubule:
Antworten
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reabsorb about 50 % of the water filtered by the glomeruli
-
reabsorb all filtered aminoacide
-
reabsorb all filtered proteins
-
reabsorb sodium in exchange for hydrogen or potassium ions
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determine the final composition of urine
Frage 39
Frage
Renal blood flow falls:
Antworten
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about 10 % when arterial pressure increases 10% above normal
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about 5% when metabolic activity in the kidney falls by 5%
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during emotional stress
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after small haemorrhage
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gradually from the inner medulla to the outer cortex per unit weight of tissue
Frage 40
Antworten
-
and glucose have different molar concentrations in normal blood
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clearance is higher, than creatinins one
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is actively secreted by the renal tubular cells into the tubular fluid
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concentration in blood may rise ten-fold after a high protein meal
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causes diuresis when its blood concentration is increased
Frage 41
Frage
The renal clearance of:
Antworten
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Inulin provides an estimate of glomerular filtration rate
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Chloride increases after an injection of aldosterone
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PAH falls when the PAH load exceeds the Tm for PAH
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Urea is higher than that of insulin
-
Inulin is dependent of its plasma concentration
Frage 42
Antworten
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is a steroid hormone, secreted by the adrenal medulla
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production ceases following removal of the kidneys and their juxtaglomerular cells
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production decreases in treatment with drugs which block angiotensin-converting enzyme
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secretion results in increased potassium reabsorption by the nephron
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secretion results in a fall in plasma volume
Frage 43
Frage
In healthy people, urinary:
Antworten
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clearance of glucose differs 0, if its plasma concentration is below 11,1mmol.1-1
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osmolality ranges from 200-400 mosmol/litre
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colour is due to small quantities of bile pigments
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pH falls as dietary protein rises
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calcium excretion is decreased by parathormone
Frage 44
Frage
The renal clearance
Antworten
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glucose is above 0, if the plasma concentration of a given substance is below 11, mmol.1-1
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of urea is higher than creatinin‘s one
-
of glucose provides an estimate of renal plasma flow
-
of phosphate is decreased by parathormone
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of protein is normally zero
Frage 45
Frage
Secretion of renin:
Antworten
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occurs in the stomach during infancy
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is stimulated by the hormone angiotensin 1
-
is stimulated by a fall in extracellular fluid volume and leads to raised levels of angiotensin II in the blood
-
inhibits the secretion of aldosterone
-
inhibits ACTH secretion by the pituitary gland
Frage 46
Frage
Diabetes insipidus (deficiency of antldiuretic hormone) causes a fall in the:
Antworten
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osmolality of the urine
-
reabsorption of water from the proximal tubules
-
extracellular but not intracellular fluid volume
-
extracellular fluid osmolality
-
intracellular fluid osmolality
Frage 47
Frage
Dialysis fluid used in the treatment of renal failure should contain the normal plasma levels of:
Antworten
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urea
-
potassium
-
osmolarity
-
plasma proteins
-
hydrogen ions
Frage 48
Frage
Long-standing obstruction of the urethra may cause:
Antworten
-
enlargement of the prostate gland
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dystrophy of the bladder muscle
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dilation of the ureters and reduction of the glomerular filtration rate
-
increase and reduction of the glomerular filtration rate
-
a decrease in residual volume in the bladder
Frage 49
Frage
Emptying of the bladder may be less effective if:
Antworten
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the sympathetic nerves carrying afferent information from bladder to the spinal cord are cut
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the pelvic nerves are cut or anticholinergic drugs are administered
-
cholinergic agonists are administered
-
alpha-adrenergic receptor antagonists are administered
-
beta-adrenergic receptor blockers are administered
Frage 50
Frage
Drugs which interfere with active transport of sodium in the proximal tubule tend to increase:
Antworten
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urine production
-
plasma osmorality
-
chloride reabsorbtion
-
intestinal fluid volume
-
plasma volume
Frage 51
Frage
A drug which inhibits carbonic anhydrase:
Antworten
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decreases bicarbonate formation and reabsorption in the kidney
-
increases plasma bicarbonate levels
-
increases blood pH
-
increases urinary loss of potassium ions
-
increases urinary volume and pH
Frage 52
Frage
A patient with chronic renal failure usually has:
Antworten
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an increased blood urea and blood uric acid
-
a decreased blood uric acid
-
an increased creatinine clearance
-
an increased acid-base disturbance when he or she vomits
-
an increased acid-base problem on a low protein diet
Frage 53
Frage
Cutting the sympathetic nerves to the bladder may cause:
Antworten
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difficulty in emptying the bladder
-
loss of tone in the internal sphincter of the bladder and loss of pain sensation in the bladder
-
loss of tone in the external sphincter of the bladder
-
increased pain sensation in the bladder
-
infertility in the female
Frage 54
Frage
Sudden (acute) renal failure differs from gradual (chronic) renal failure in that:
Antworten
-
potassium retention tends to be more severe
-
blood urea levels tend to be higher
-
depression of bone marrow activity is unlikely to occur
-
metabolic acidosis is usually not a problem
-
dietary protein restriction is unnecessary
Frage 55
Frage
A long-standing increase in arterial pCO2 (respiratory acidosis) leads to:
Antworten
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an increase in renal bicarbonate formation
-
a decrease in urinary ammonium salts
-
a decrease in plasma potassium concentration
-
an increase of the monohydrogen/dihydrogen phosphate ratio in urine
-
a decrease in urinary bicarbonate excretion
Frage 56
Frage
The inhibition of the antidiurctic hormone (ADH), say by alcohol, would have what affect?
Antworten
-
constriction of the afferent arteriole
-
inhibition of diuresis
-
stimulation of water conservation
-
constriction of the efferent arteriole
-
reduction in water conservation by the kidneys
Frage 57
Frage
Reabsorption of amino acids from the filtrate requires many different protein carriers because:
Antworten
-
denaturation may occur
-
this transport is not competitive
-
there are only 10 different amino acids
-
transport of amino acids is typically highly specific
-
glucose inhibits amino acid transport
Frage 58
Frage
Reabsorption (transport) of both N a‘“ and glucose together from the renal lumen is an example of:
Antworten
-
facilitated diffusion
-
secondary passive transport
-
primary direct active transport
-
secondary indirect active antiport
-
secondary indirect active symport
Frage 59
Frage
Drinking a litre of water:
Antworten
-
increases secretion of antidiuretic honnone
-
reduces the plasma sodium concentration
-
increases osmolarity of the urine
-
causes body cells to shrink
-
decreases the specific gravity of the body
Frage 60
Frage
An acid-base buffer system:
Antworten
-
can be a mixture of a weak acid and its conjugate base
-
can be a solution of sodium and bicarbonate ions
-
prevents any change in pH when acid is added
-
works best when acid and base are equal in concentration
-
is hemoglobin as an example of intracellular buffer
Frage 61
Frage
Acidosis in a patient may lead to:
Antworten
-
increased urinary excretion of potassium
-
hypoventilation
-
a blood pH of less than 5.5
-
an urinary pH of less than 5.5
-
tetany
Frage 62
Frage
A rise in the osmolality of extracellular fluid may lead to:
Antworten
-
thirst and release of vasopressin
-
increased water reabsorption in the proximal convoluted tubules
-
a decrease of vasopressin secretion
-
an increase in intracellular fluid volume
-
suppression of sweat secretion
Frage 63
Frage
A raised blood pH and bicarbonate level is consistent with:
Antworten
-
metabolic acidosis
-
partly compensated respiratory alkalosis
-
a reduced pCO2
-
chronic renal failure with a raised pCO2
-
a history of persistent vomiting of gastric contents
Frage 64
Frage
A patient with partly compensated respiratory acidosis:
Antworten
-
must have a raised pCO2
-
must have a raised bicarbonate concentration [HCO3-]
-
may have evidence of renal compensation
-
may have respiratory failure due to hypoventilation
-
all of the above
Frage 65
Antworten
-
occurs for several days after major surgery
-
expands the extracellular fluid volume
-
expands the blood volume
-
increases the severity of oedema
-
all of the above
Frage 66
Frage
Sodium depletion differs from water depletion in that:
Antworten
-
cardiovascular changes are less pronounced
-
intracellular fluid volume is less affected
-
the haematocrit increases
-
thirst is more severe
-
antidiuretic hormone levels are higher
Frage 67
Frage
A high blood potassium level (hyperkalaemia):
Antworten
-
occurs in acute renal failure
-
follows severe crush injuries to the limbs
-
may diminish cardiac performance and cause death
-
may be reduced by Intravenous infusion of insulin and glucose
-
all of the above
Frage 68
Frage
A raised level of calcium in the blood (hypercalcaemia):
Antworten
-
may occur when parathyrord activity decreases
-
may occur when the plasma protein level falls
-
may occur in chronic renal failure
-
increases the risk of stone formation in the urinary tract
-
causes increased excitability of nerve and muscle
Frage 69
Frage
Thirst is stimulated by:
Antworten
-
increase in plasma osmolality and volume
-
increase in plasma osmolality and decrease in volume
-
decrease in osmolality and increase in volume
-
decrease in plasma osmolality and volume
-
increase in intracelular volume