409855
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
almost 11 years ago
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| Question | Answer |
| No of Types of Raf | 3- A,B & C |
| Most important form of Raf | B-Raf |
| Mutation making Raf an oncogene | Val-Glutamine |
| 14-3-3- Family | Interact with phospho-serine by forming heterodimers |
| 14-3-3 Binding on B-Raf | Ser-259 & Ser 691 |
| Dephosphorylation of Ser... once recruited to membrane | Ser 259 |
| Membrane Associated Kinases | Phosphorylate Raf to activate it |
| Cytosolic Kinases | Rephosphorylate Ser259 when Raf is removed from the membrane |
| Activation of Mek | Phosphorylation on Serine/Threonine |
| CD Domain of Erk | TEY sequence (T & Y phosphorylated by MEK) |
| Once phosphorylated, Erk... | Signals the nucleus (including phosphorylation of TCF/ELK1) |
| Does ERK enter the nucleus? | Yes |
| p90rsk | Activated by ERK & enters nucleus |
| NF(Kappa)B Activation | Releases transcription factor to enter nucleus |
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