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412799
Apoptosis
Description
Year 2 Quiz on Apoptosis, created by gina_evans0312 on 03/12/2013.
No tags specified
cell signalling and cancer
oncogenes
year 2
Quiz by
gina_evans0312
, updated more than 1 year ago
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Created by
gina_evans0312
about 11 years ago
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Resource summary
Question 1
Question
What is the main difference between apoptosis and necrosis?
Answer
In necrosis release of cell contents is controlled In apoptosis it's not
In apoptosis release of cell contents is controlled In necrosis it's not
Question 2
Question
What protein condenses during apoptosis
Answer
Chromatin
Actin
Myosin
Question 3
Question
What form are caspases usually found in?
Answer
Inactive, with their DED domain tails intact
Active, with their DED domain tails intact
Inactive, with their DED domain tails removed
Active, with their DED domain tails removed
Question 4
Question
What is required for caspase activation?
Answer
Addition of a DED domain tail
Removal of the DED domain tail
Question 5
Question
What are the roles of the 2 main caspases?
Answer
3 is the initation 8 does most damage
8 is the initiator 3 does most damage
Question 6
Question
Which of the following are survival/protector proteins that inhibit caspase activation?
Answer
BAX, BAD, PUMA
Bci-2, Mcl1, A1
Question 7
Question
What is required for ligand acitvated apoptosis?
Answer
For the receptors to contain DED domains
For the receptors to be bound to caspases
For the receptors to be expressed only in certain areas of the cell membrane
Question 8
Question
What protein inhibits the activation of apoptic receptors?
Answer
Flp
Flr
Fld
Question 9
Question
Name an apoptic receptor
Answer
Fas
Far
Fam
Question 10
Question
How does the receptor activate caspase 8?
Answer
By recruiting it and cleaving off the DED domain
By recruiting it and adding a DED domain
Question 11
Question
Name the two methods caspase 8 uses to destroy the cell
Answer
Activation of Caspase 3
Deactivation of Caspase 3
Damage to mitochondria, which releases Cyt. C
Question 12
Question
What does mitochondrial damage do to Casp 9?
Answer
Activates it
Deactivates it
Question 13
Question
What happens when essential growth factors are withdrawn from the cell?
Answer
PI3K cannot activate
PKB cannot activate
Casp 8 cannot activate
Question 14
Question
How does PKB inhibit apoptosis?
Answer
Releases Bad from Blc-2
Releases Blc2 from Bad
Question 15
Question
Identify methods which cells can use to evade apoptosis
Answer
Decreased Fas receptor expression
Inc Blc2 & decrease bax/bad expression
Loss of Casp 8
Increased Flp expression
Soluble fas to causes apoptosis in t-cells
Large amounts of Fas ligand produced to kill t-cells
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