The Citric Acid Cycle

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Exercise Metabolism- Term 1 (TCA Cycle) Flashcards on The Citric Acid Cycle, created by Mark Arsenal on 15/04/2013.
Mark Arsenal
Flashcards by Mark Arsenal, updated more than 1 year ago
Mark Arsenal
Created by Mark Arsenal over 11 years ago
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Resource summary

Question Answer
What factors inhibit Pyruvte Dehyrodgenase? High levels of NADH or NAD, High levels of Acetyl Co-A, High levels of ATP/ADP.
Anaplerosis: Series of enzymatic reactions that replenish intermediates.
What factors stimulate Pyruvate Dehydrogenase? Non-Acetylated CoA and NAD+.
Cataplerosis: Series of enzymatic reactions that remove intermediates.
Does TCA Intermediate availability play any role in causing fatigue? No. TCA intermediates never fall below a certain point thus not a cause of fatigue.
What does the Alanine Aminotransferase Reaction do? It generates TCA intermediates at the onset of exercise.
TCA cycle is regulated by: Intermediate availability. Acetyl CoA availability. The enzymes are controlled by Ca, ATP and ADP.
What do we breakdown and form in TCA cycle?? We break down Pyruvate into energy rich NADH and FADH (for breakdown in ETC)
Where does the TCA take place? Mitochondrial Matrix of the Cell
What do we get from TCA? 3 NADH, 1 FADH, 1 GTP and 2 CO2
What is GTP? Guanosine Triphosphate. It helps us make ATP. It costs 2 GTP per 8 cycles of the TCA. Thus in 8 cycles we get 6 ATP.
Does Pyruvate have to be broken down before entering the TCA cycle? Yes- It is broken down to Acetyl-CoA by Pyruvate Dehydrogenase.
Intermediates of TCA: Acetyl CoA, Citrate, Isocitrate, Alpha Ketoglutarate, Succinyl CoA, Succinate, Fumarate, Malate, Oxaloacetate.
Enzymes of TCA Cycle: Citrate Synthase, Aconitase Isocitrate Dehydrogenase, Alpha Ketoglutarate Dehydrogenase, Succinyl CoA Synthetase, Succinate Dehydrogenase, Fumarase, Malate Dehydrogenase.
What is the process? Through a series of reactions we cleave 2 carbon atoms from a 6 carbon atom substance. This is Citrate- formed from 2 carbon atom Acetyl CoA and 4 carbon atom Oxaloacetate)
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