Flashcards
Gluconeogenesis
Cards in this deck (8)
- 1What are the precursors of Gluconeogenesis?Lactate- Generated in the muscles, it travels to the liver where it is broken down into Pyruvate then goes through Gluconeogenesis to form Glucose. Amino Acid Breakdown- form gluconeogenic intermediates which thus upregulate Gluconeogenesis. Glycerol- From Beta-oxidation, can be converted to form Gluconeogenesis intermediate which can work up to form Glucose.
TCA Intermediates- Stimulate Gluconeogenesis through conversion to oxaloacetate (builds up-which stimulates) - 2What do we input and output in Gluconeogenesis?We input 2 pyruvate+4ATP+2GTP+NADH. We Output Glucose+4ADP+2GDP+6Pi
- 3Where are the only 2 locations that Gluconeogenesis can occur?Liver and the Kidney.
- 4What do we breakdown and form in Gluconeogenesis?Pyruvate to Glucose (Opposite to Glycolysis)
- 5Where does Gluconeogenesis take place?Liver
- 6What Important Organ is the prime user of Glucose as fuel?Brain
- 7How are Gluconeogenesis and Glycolysis linked?Glycolysis breaks down Glucose to Pyruvate. Gluconeogenesis forms Glucose from Pyruvate. The 2 pathways are reciprocal, when 1 pathway is active the other is inhibited.
- 8The pathway and Intermediates in Gluconeogenesis are the same as in Glycolysis (Just other way round). However Pyruvate is broken down to Oxaloacetate before becoming Phosphoenolopyruvate.Gluconeogenesis Specific Enzymes- Pyruvate Carboxylase, Phosphoenolpyruvate Carboxykinase, Fructose 1,6 Biphosphatase, Glucose 6 Phosphatase.
"Pathway Produces Fresh Glucose"
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- Exercise Metabolism- Term 1 (Gluconeogenesis) Flashcards on Gluconeogenesis, created by Mark Arsenal on 15/04/2013.
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- Mark Arsenal
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